Published: 23 November 2020
Author(s): Peter W. Horby, Jonathan R. Emberson
Issue: January 2021
Section: Commentary

The place of hydroxychloroquine in the prevention and treatment of COVID-19 has been controversial, with contrasting claims and high-emotions. It was initially proposed as treatment or prophylaxis for COVID-19 based upon data reporting that chloroquine and hydroxychloroquine inhibited SARS-CoV-2 virus replication in cell culture systems. Interest accelerated rapidly as early reports from observational studies of clinical efficacy in COVID-19 patients emerged and hydroxychloroquine soon began to appear in clinical treatment guidelines.

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