January 2021

120 Articles

No Section

Cardiac imaging in heart failure in the personalized medicine era: Pathway to knowledge or Tiresias’ paradox?

8 January 2021
Author(s): Gherardo Finocchiaro, Gerald Carr-White, Gianfranco Sinagra

Tiresias was the blind prophet of Apollo in Thebes. His figure finds roots in Greek mythology and recurs in literature and art. In Sophocles' Oedipus Rex, Tiresias discloses an appalling truth to... more

Pulmonary congestion and mortality during venoarterial extracorporeal membrane oxygenation (VA-ECMO): does time matter?

19 December 2020
Author(s): Pieter S. van der Wal, Peter-Paul Zwetsloot, Olaf L. Cremer, Dirk W. Donker, Christiaan L. Meuwese

In a recent edition of this Journal, an intriguing study was published which examined the association between (development of) pulmonary congestion (PC) and mortality in patients with post-cardiotomy... more

Anticoagulation dosing in atherosclerotic cardiovascular disease: Is less more?

16 December 2020
Author(s): Alexander C. Fanaroff, Renato D. Lopes

Pivotal randomized clinical trials (RCTs) conducted in the 1970s and 1980s comparing aspirin with placebo in patients with prior myocardial infarction established antithrombotic agents as mainstays... more

Lower dose direct oral anticoagulants and improved survival: A combined analysis in patients with established atherosclerosis

3 November 2020
Author(s): Riccardo Cappato, Mauro Chiarito, Michela Giustozzi, Martina Briani, Hussam Ali, Letizia Riva, Gianluca Bonitta, Corrado Lodigiani, Francesco Furlanello, Cristina Balla, Pierpaolo Lupo, Giulio Stefanini

Anti-thrombotic and anti-coagulation effects of direct oral anticoagulants (DOACs) are dose-dependent [1–5]. Conversely, the benefit from higher dose DOACs is counterbalanced by a dose-dependent risk... more

Disease- and gender-related characteristics of coeliac disease influence diagnostic delay

28 September 2020
Author(s): Marco Vincenzo Lenti, Antonio Di Sabatino

Coeliac disease is a high-prevalent, immune-mediated, chronic enteropathy caused by the ingestion of gluten in genetically susceptible individuals [1,2]. From the clinical viewpoint, coeliac disease... more

The 2020 International Society of Hypertension global hypertension practice guidelines - key messages and clinical considerations

22 September 2020
Author(s): Paolo Verdecchia, Gianpaolo Reboldi, Fabio Angeli

The International Society of Hypertension (ISH) has recently developed practice guidelines for the management of hypertension in adults aged ≥18 years. Conceptually, the 2020 ISH Guidelines are... more

Predicting spontaneous conversion to sinus rhythm in symptomatic atrial fibrillation: The ReSinus score

17 September 2020
Author(s): Jan Niederdöckl, Alexander Simon, Filippo Cacioppo, Nina Buchtele, Anne Merrelaar, Nikola Schütz, Sebastian Schnaubelt, Alexander O Spiel, Dominik Roth, Christian Schörgenhofer, Harald Herkner, Hans Domanovits, Michael Schwameis

In patients with symptomatic atrial fibrillation rates of spontaneous conversion are high.1-3 In real-world emergency cohorts optimal management is unclear; however, treatment with early... more


Sex, age and venous thrombosis—Are men and women indeed from different planets?

5 January 2021
Author(s): Sabine Eichinger, Paul A. Kyrle

“Mars or Venus” titled Elliot and Rubin their editorial that accompanied the landmark study which described for the first time the strikingly higher risk of recurrent venous thromboembolism (VTE) in... more

COPD is not only one of the several VTE risk factors

24 December 2020
Author(s): Laurent BERTOLETTI, Francis COUTURAUD

Chronic obstructive pulmonary disease (COPD) is a frequent and severe chronic respiratory disease [1]. It is ranked in the 5th main causes of death worldwide [1]. Patients with COPD suffer from... more

Sodium: sign, signifier, or signified, of sepsis?

16 December 2020
Author(s): Mai O'Sullivan, Kevin F McCarthy

85% of the known universe is made up of something we cannot directly observe as it does not absorb, emit, or reflect light. We can only infer the existence of dark matter through its effects on... more

Increasing the impact of Post Authorisation Safety Studies: transparency is key

1 December 2020
Author(s): Xavier Kurz, Peter Arlett, Hans-Georg Eichler, Alexis Nolte, Sabine Straus, Guido Rasi

In ETNA VTA Europe: A contemporary snapshot of patients treated with edoxaban in clinical practice across eight European countries, Cohen et al. report the results of a non-interventional drug... more

Hydroxychloroquine for COVID-19: Balancing contrasting claims

23 November 2020
Author(s): Peter W. Horby, Jonathan R. Emberson

The place of hydroxychloroquine in the prevention and treatment of COVID-19 has been controversial, with contrasting claims and high-emotions. It was initially proposed as treatment or prophylaxis... more

Large-scale use of hydroxychloroquine for COVID-19 confirms safety, if not effectiveness

28 October 2020
Author(s): Giulio Cavalli, Lorenzo Dagna

In this issue of the Journal, Di Castelnuovo and colleagues report the findings of the observational multicentre Italian CORIST Study on the use of hydroxychloroquine (HCQ) in hospitalised COVID-19... more

Venous thromboembolism and COVID-19: Mind the gap between clinical epidemiology and patient management

22 October 2020
Author(s): Michela Giustozzi, Maria Cristina Vedovati, Giancarlo Agnelli

Since the beginning of the coronavirus disease-2019 (COVID-19) pandemic, a compelling evidence of the association between this infection and an increased risk of venous thromboembolism has drawn the... more

Hypertension guidelines: Managing the differences or the patients?

19 October 2020
Author(s): AJ Manolis, LE Poulimenos, MS Kallistratos

Clinical guidelines summarize and evaluate all evidence available on a topic, with the aim of assisting physicians in selecting the best diagnostic and therapeutic strategies for an individual... more

Does hydroxychloroquine reduce mortality for COVID-19?

16 October 2020
Author(s): Silvano GALLUS, Antonio CLAVENNA, Alessandra LUGO

A paper published in this issue of the European Journal of Internal Medicine shows results from the COVID-19 RISK and Treatments (CORIST) Collaboration Study [1]. The authors analysed data from a... more

Utilize the full potential of real world evidence

7 October 2020
Author(s): Rupert Bauersachs

After the pivotal phase 3 trials on venous thromboembolism (VTE) treatment with non-vitamin K antagonist oral anticoagulants (NOACs) had been performed some 10 years ago, these drugs have now become... more

European Journal of Internal Medicine: IM Flashcards

Atypical chest pain with precordial T wave inversions

10 October 2020
Author(s): Leah Weston, Hani Alkhatib, Susrutha Kotwal

A 74-year-old woman with a prior history of coronary artery disease presented to the emergency department with intermittent, burning epigastric pain. Five months prior, she had a stress... more

Internal Medicine Flashcard

Family rash

24 November 2020
Author(s): Fabrizio Elia, Moreno Dutto, Valeria Milazzo

A healty 35-year-old woman suddenly developed a papular rash with linear disposition, involving predominantly her arms. She had no history of allergies and did not take any medication; moreover she... more

Concomitant pulmonary and rib lesions in a 44-year-old male nonsmoker

23 November 2020
Author(s): De-an Qin, Jie Jiang, Yun-peng Wang

A 44-year-old male nonsmoker presented to the respiratory department with progressive left chest pain for 20 days. He had previously been healthy with normal immunity. He had no cough, fever,... more

“High absorption area in the pelvis”

23 November 2020
Author(s): Jin Ikeda

A 42-year-old man presented to our emergency room with epigastric pain. He had undergone a barium examination 6 weeks previously for gastric cancer screening. He was apyrexial. Physical examination... more

Bilateral foot drop and cherry skin lesion

21 November 2020
Author(s): Chen Fei Ng, Rabani Remli

A 34-year-old woman with no previous medical history presented with bilateral lower limbs weakness and numbness for three months. It was progressively worsening that she required wheelchair for... more

Spontaneous discoloration of the finger in a 67-year-old woman

18 November 2020
Author(s): Hiroaki Nakagawa, Yasushi Miyata

A 67-year-old woman presented to our clinic because she had developed spontaneous pain and purple discoloration of the fourth finger of her right hand that had started the previous day. She had... more

Chronic urticaria with inflammation

15 November 2020
Author(s): Hiroshi Hori, Takahiko Fukuchi, Hitoshi Sugawara

A 67-year-old man presented with a 15-year history of chronic urticaria. It was distributed symmetrically on the limb trunk (Fig. 1A and B) without pruritus. No fever or joint pain or headache is... more

Bright liver: a surprise discovery

29 September 2020
Author(s): Daisuke Murakami, Hideaki Harada, Yuji Amano

A 69-year-old woman with hypothyroidism, alcoholic liver disease, coronary artery disease, ventricular arrhythmia requiring placement of an implantable cardioverter defibrillator, and end-stage renal... more

A middle-aged woman with acute onset of fever, altered mental status, and movement disorder

25 September 2020
Author(s): Yusaku Kajihara

A 60-year-old woman was admitted in the emergency room with acute onset of fever, altered mental status, and movement disorder. The patient had well-controlled type 2 diabetes mellitus with... more

Internal Medicine Flashcards

A middle-aged woman with numbness and weakness of the extremities

23 September 2020
Author(s): Keizo Tanitame

A 45-year-old woman presented to the neurology department with numbness and weakness of extremities, which had progressed during 3 months. The patient had tingling sensation in the left neck.... more

Disturbance of consciousness after postpartum hemorrhage

23 September 2020
Author(s): Keizo Tanitame, Chinatsu Akagi, Nobuyuki Kamaki

A 37-year-old woman with postpartum hemorrhage was transferred by ambulance to our hospital for emergency treatment. On arrival massive hemorrhage continued, and she developed tachycardia (130 beats/... more

Invited Article

PPI co-therapy and gastrointestinal bleeding with antithrombotic drugs: A step forward but not enough

21 January 2021
Author(s): Angel Lanas

Nonvariceal gastrointestinal (GI) bleeding is common and one of the most frequent medical events which determine hospitalizations worldwide. Death rates (5-12%) in patients with GI bleeding are... more

Letter to the Editor

Do four SGLT2 inhibitors lead to different cardiorenal benefits in type 2 diabetes, in chronic heart failure, and in chronic kidney disease?

20 January 2021
Author(s): Mei Qiu, Liang-Liang Ding, Ze-Lin Zhan, Hai-Rong Zhou

Large randomized trials have confirmed the cardiorenal benefits from sodium-glucose transporter 2 (SGLT2) inhibitors for patients with type 2 diabetes (T2D), for patients with chronic heart failure... more

Less is more: Perspectives from the European Code Against Cancer

16 January 2021
Author(s): Christos Tsagkaris, Parvathy Mohanan

We have read the article of Kherad et al. with great interest. The authors elaborate on the “less is more” principle, which has become quite relevant in various areas of medicine including cancer [1... more

Mid-day sleep and blood pressure in patients with arterial hypertension. Author's reply

5 January 2021
Author(s): MS Kallistratos, LE Poulimenos, AJ Manolis

We thank Dr Kawada for his comments on our study [1]. He raised some concerns regarding the effect of mid-day sleep on alertness and performance as well as health outcomes. He based his concerns on... more

Proprotein Convertase Subtilisin-Kexin Type 9 inhibitors and stroke prevention: A meta-analysis

5 January 2021
Author(s): Dimitrios Sagris, George Ntaios, Georgios Georgiopoulos, Konstantinos Pateras, Haralampos Milionis

Dear Editor, over the last decades lipid-modifying strategies made a pivotal change in cardiovascular prevention especially in patients with previous coronary artery disease or ischemic stroke. In... more

Flying higher than politics: The goal of preventive medicine at the time of the COVID-19 pandemic

1 January 2021
Author(s): Francesco M. Galassi, Michael E. Habicht, F. Donald Pate, Elena Varotto

The present SARS-CoV-2-caused COVID-19 pandemic [1] has clearly shown that great health crises can elicit heated political and scientific debates. The history of medicine teaches us how, throughout... more

Associating enterococcal endocarditis and colorectal neoplasia: is colonoscopy mandatory? – Authors’ reply

31 December 2020
Author(s): Lorenzo Bertolino, Maria Paola Ursi, Rosa Zampino, Emanuele Durante-Mangoni

We are glad to share with Corredoira and colleagues the interest for our recently published work regarding the relationship between Enteroccocus spp infective endocarditis (EIE) and colorectal... more

Heart rate turbulence in obstructive sleep apnea syndrome: The effect of short-term CPAP therapy

31 December 2020
Author(s): Giovanni D'Addio, Alberto De Felice, Leandro Donisi, Alberto Braghiroli, Mauro Maniscalco

Patients affected by obstructive sleep apnea (OSA) present an increased risk of cardiovascular (CV) events [1]. This is likely due to the imbalance in the autonomic nervous system, with cardiac... more

Low influenza vaccination coverage among hospitalized COVID-19 patients in Milan: A gap to be urgently filled

29 December 2020
Author(s): Anna Lisa Ridolfo, Laura Milazzo, Andrea Giacomelli, Letizia Oreni, Catia Borriello, Spinello Antinori

The first wave of the COVID-19 epidemic in Italy during March and April 2020 put extreme pressure on the national healthcare system, particularly on the hospitals in the most affected regions of... more

NEWS2 is a valuable tool for appropriate clinical management of COVID-19 patients

21 December 2020
Author(s): Marta Rigoni, Emanuele Torri, Giandomenico Nollo, Livia Delle Donne, Susanna Cozzio

Coronavirus disease 2019 (COVID-19) is a severe acute respiratory infection caused by an emergent coronavirus, SARS-CoV-2, recognized in Wuhan (China) in December 2019. The World Health Organization... more

From the CHA2DS2-VASc score to inflammation: a path leading to frailty? An update of the PURE-Rhythm Trial

16 December 2020
Author(s): Stefano Fumagalli, Claudia Di Serio, Giulia Ricciardi, Gregory Y.H. Lip, Niccolò Marchionni, for the PURE-Rhythm Trial Investigators

Atrial fibrillation (AF) is the most frequently sustained arrhythmia diagnosed in elderly patients. AF is associated with an increased thrombo-embolic risk and with the development of heart failure... more

Comparative analysis of adropin concentration changes in response to kidney transplantation

16 December 2020
Author(s): Elżbieta Cecerska-Heryć, Daria Adamiak, Natalia Serwin, Bartłomiej Grygorcewicz, Barbara Dołęgowska

Adropin acts as an energy regulator through lipid and glucose metabolism [1,2]. This 76 amino acid protein encoded by the ENHO (Energy Homeostasis Associated Gene) gene is primarily expressed in the... more

Prevalence and influence of gastroesophageal reflux symptoms on sleep apnea and sleepiness

3 December 2020
Author(s): Dejan Radovanovic, Stefano Pini, Maurizio Rizzi, Elisa Franceschi, Pierachille Santus

To the Editor,

Home-based COVID 19 management: A consensus document from Italian general medical practitioners and hospital consultants in the Lombardy region (Italy)

2 December 2020
Author(s): Nuccia Morici, Massimo Puoti, Maria Teresa Zocchi, Carla Brambilla, Andrea Mangiagalli, Stefano Savonitto

The coronavirus disease 2019 (COVID-19) pandemic has infected more than 56,628,581 people causing 1,406,449 deaths worldwide, as of November 24, 2020. [1] Among the 17,131,853 active cases (November... more

Prognostic Implications of Residual Pleural Effusions at Discharge in Patients with Acute Decompensated Heart Failure

1 December 2020
Author(s): Hidenori Yaku, Yuta Seko, Takao Kato, Takeshi Morimoto, Takeshi Kimura

Pleural effusion, which is included as one of the Framingham minor diagnostic criteria for heart failure (HF), is one of the common signs reflecting body fluid retention and can be quickly and... more

Angiotensin-converting enzyme inhibitors versus angiotensin II receptor blockers for renal outcomes and mortality in diabetic kidney disease

26 November 2020
Author(s): Shimin Jiang, Jinying Fang, Tianyu Yu, Wenge Li

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Inhibition of intrarenal renin-angiotensin system (RAS) with angiotensin-converting enzyme inhibitors (... more

Associating enterococcal endocarditis and colorectal neoplasia: is colonoscopy mandatory?

20 November 2020
Author(s): J. Corredoira, E. Romay, J.M. Pericàs, J.M. Miró

Dear Editor:

Sodium fluctuation, a novel single parameter to predict hospital mortality

19 November 2020
Author(s): Siyu Liang, Shi Chen, Yuelun Zhang, Huijuan Zhu, Hui Pan

Dysnatremia is the most common electrolyte disorder in hospitalized patients [1]. Dysnatremia is generally classified as hyponatremia (145mmol/L). Many studies showed that hypernatremia and... more

Prescription of interleukin-1 inhibitors in a French adult cohort of familial Mediterranean fever

19 November 2020
Author(s): Antoine Fayand, Léa Savey, Stéphanie Ducharme-Bénard, Gilles Grateau, Sophie Georgin-Lavialle

Dear Editor,

The COVID-19 burden for health care professionals: Results of a global survey

13 November 2020
Author(s): Matthias Schneider, Martin Altersberger, Christina Binder, Christian Hengstenberg, Thomas Binder

At the end of December 2019, a novel coronavirus (SARS-CoV-2) started to spread in the city of Wuhan, Hubei province in China, first described as novel coronavirus [1,2]. Meanwhile, the current COVID... more

Risk of infectious events in acute myocardial infarction patients treated with ticagrelor or clopidogrel

13 November 2020
Author(s): Cheng-Han Lee, Hui-Wen Lin, Nan-Yao Lee, Sheng-Hsiang Lin, Yi-Heng Li

Ticagrelor is an oral direct-acting antiplatelet agent that inhibits P2Y12 receptor activation. The PLATO study showed that ticagrelor significantly reduced the composite outcome of vascular death,... more

End-Stage renal disease and 30-day mortality for adults with and without COVID-19

8 November 2020
Author(s): Stephanie L. Harrison, Benjamin J.R. Buckley, Elnara Fazio-Eynullayeva, Paula Underhill, Deirdre A. Lane, Gregory Y.H. Lip

Emerging evidence suggests that people with chronic kidney disease have a higher risk of severe infection with coronavirus disease 2019 (COVID-19) [1]. Furthermore, acute kidney injury is common... more

What changed in the Italian internal medicine and geriatric wards during the lockdown

7 November 2020
Author(s): Barbara D'Avanzo, Alessandro Nobili, Mauro Tettamanti, Luca Pasina, Pier Mannuccio Mannucci, the REPOSI Study Group

Italy was the most affected European country in the first few weeks of the COVID-19 pandemic, with a dramatic burden on sub-intensive and intensive care units. Among the several arrangements... more

Time to speed up–the rate at which we correct hypernatremia

5 November 2020
Author(s): M. Jongejan, L.J. Vleming

Hypernatremia is a common electrolyte disorder. It is defined as a serum sodium concentration > 145 mmol/L and is a hyperosmolar state in which there is a deficit in total body volume relative to... more

Temporal changes in co-morbidities and mortality in patients hospitalized for COVID-19 in Italy

30 October 2020
Author(s): Fabio Angeli, Tiziana Bachetti, for the Maugeri Study Group

In response to the growing pandemic of Coronavirus Disease 2019 (COVID-19) in Italy, the Italian government imposed a strict nationwide quarantine which began on March 9, 2020. The restrictive... more

Autoimmune disorders and venous thromboembolism: An update from the COMMAND VTE registry

24 October 2020
Author(s): Yugo Yamashita, Takeshi Morimoto, Kazushige Kadota, Koh Ono, Takeshi Kimura

There are various well-known predisposing risk factors for development of venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), and several studies reported... more

Determinants of circulating angiotensin-converting enzyme 2 protein levels in the general population

19 October 2020
Author(s): Tatiana Kuznetsova, Nicholas Cauwenberghs

Similar to SARS-CoV, the novel coronavirus (SARS-CoV-2) uses the angiotensin-converting enzyme 2 (ACE2) receptor to infiltrate target cells [1]. Previous experimental study provided the genetic proof... more

Risk of thrombosis, pregnancy morbidity or death in antiphospholipid antibodies positive patients with or without thrombocytopenia

17 October 2020
Author(s): Thomas Moulinet, Virginie Dufrost, Isabelle Clerc-Urmès, Denis Wahl, Stéphane Zuily

Antiphospholipid syndrome (APS) is an immune-mediated acquired disorder characterized by venous, arterial or small vessels thromboses and/or obstetrical morbidity, and the persistent presence of... more

Disease course in patients with systemic autoimmune diseases: insights on the safety of immunosuppression during the SARS-CoV-2 outbreak in Italy

15 October 2020
Author(s): Devis Benfaremo, Lucia Perini, Valentina Marconi, Michele Maria Luchetti, Armando Gabrielli

From December 2019 the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for the Coronavirus Disease 2019 (COVID-19), has caused a pandemic, with over 28 million cases and... more

COMPASS vs PEGASUS approach in a comparative budget impact analysis.

10 October 2020
Author(s): Natale Daniele Brunetti, Luisa De Gennaro, Michele Correale, Riccardo Ieva, Francesco Santoro

The treatment of coronary artery disease (CAD), peripheral artery disease (PAD) and ischemic heart disease (IHD), has been radically modified in the recent past by the implementation of the results... more

Significant increase in the incidence of high-risk pulmonary embolism during the COVID-19 shutdown: The pandemic response causes serious collateral consequences

6 October 2020
Author(s): Paul Gressenberger, Thomas Gary, Reinhard B. Raggam, Andrea Borenich, Marianne Brodmann

When the novel coronavirus disease (COVID-19) started to spread globally in December 2019 and COVID-19 related deaths continued to increase rapidly [1], the World Health Organization (WHO) declared a... more

Is the 2020 Sampson equation the best formula for LDL-C estimation?

22 September 2020
Author(s): Federica Piani, Arrigo F.G. Cicero, Claudio Borghi, Sergio D’Addato, on behalf of the BLIP Study group

Dear Editor,

Trans-catheter valve implantation and patient outcomes: Focus on the kidney

24 August 2020
Author(s): Giuseppe Boriani, Salvo Arrotti, Davide Gabbieri, Paolo Magnavacchi, Fabio Alfredo Sgura

In 2012 the Kidney Disease Improving Global Outcomes organization published a guideline focused on the definition and management of acute kidney injury (AKI) [1] which became an important reference... more

Healthy and non healthy obese patients. The truth lies in the adipose tissue

19 August 2020
Author(s): E. Sanidas, Μ. Velliou, D. Papadopoulos, D. Iliopoulos, J. Barbetseas

Obesity is commonly correlated with metabolic complications such as insulin resistance, type 2 diabetes mellitus, dyslipidemia, arterial hypertension and metabolic syndrome that are significant risk... more

Cause of death and risk factors for mortality in AA amyloidosis: A French retrospective study

14 August 2020
Author(s): Alexandre Terré, Samuel Deshayes, Léa Savey, Gilles Grateau, Sophie Georgin-Lavialle

AA amyloidosis (AAA) is a major complication of chronic inflammation. It is the consequence of the deposition of fibrils of serum amyloid A protein (SAA) in tissues [1]. Lachman et al. prospectively... more

Renal failure after trans-catheter aortic valve implantation

7 August 2020
Author(s): Marianna Adamo, Salvatore Curello, Marco Metra

Trans-catheter aortic valve implantation (TAVI) is by now considered the treatment of choice in patients with severe and symptomatic aortic stenosis deemed at prohibitive or high surgical risk.... more

Patterns of anticoagulation for atrial fibrillation in cancer patients referred to cardio-oncological evaluation

5 August 2020
Author(s): Matteo Toma, Edlira Rrapaj, Paolo Spallarossa, Federico Guerra, Pietro Ameri

Prophylaxis of atrial fibrillation (AF)-related cardioembolism in oncology is often challenging [1]. The CHA2DS2-VASc score performs differently according to the presence or absence of cancer, with... more

Bowel resection reduces aortic pulse wave velocity in patients with ulcerative colitis. A longitudinal study

5 August 2020
Author(s): Luca Zanoli, Antonino Tuttolomondo, Giulio Geraci, Pietro Castellino

Ulcerative colitis (UC) is characterized by an involvement of the large bowel which leads to chronic systemic inflammation, increased aortic stiffness and reflected waves [1–4] and an excess of... more

Original Article

Impact of the number of comorbidities on cardiac sympathetic derangement in patients with reduced ejection fraction heart failure

20 January 2021
Author(s): Leonardo Bencivenga, Klara Komici, Grazia Daniela Femminella, Stefania Paolillo, Paola Gargiulo, Roberto Formisano, Roberta Assante, Carmela Nappi, Brunella Puzone, Immacolata Sepe, Antonio Cittadini, Dino Franco Vitale, Nicola Ferrara, Alberto Cuocolo, Pasquale Perrone Filardi, Giuseppe Rengo

Heart failure (HF) is a very prevalent condition associated with high morbidity and mortality rates, thus representing a relevant global health burden. It affects more than 26 million people... more

Cannabis is associated with blood pressure reduction in older adults – A 24-hours ambulatory blood pressure monitoring study

20 January 2021
Author(s): Ran Abuhasira, Yosef S. Haviv, Merav Leiba, Adi Leiba, Larisa Ryvo, Victor Novack

Background: Medical cannabis use is increasing rapidly in the past several years, with older adults being the fastest growing group. Nevertheless, the evidence for cardiovascular safety of cannabis... more

Validity of "Sepsis-3" criteria in identifying patients with community-onset sepsis in Internal Medicine wards; a prospective, multicenter study

12 January 2021
Author(s): Alberto Fortini, Antonio Faraone, Simone Meini, Michael Bettucchi, Benedetta Longo, Beatrice Valoriani, Silvia Forni, Italian Federation of Hospital Internists (FADOI) - Sepsis Collaboration Group of the Tuscany Region

Few data are available on the validity of “Sepsis-3” criteria in identifying patients with sepsis in internal medicine wards (IMWs). Real-life data about this topic and on the prevalence of sepsis in... more

Alcoholic liver disease and autoimmune hepatitis: Sometimes a closer look under the surface is needed

12 January 2021
Author(s): Eirini I. Rigopoulou, Nikolaos Gatselis, Pinelopi Arvaniti, George K. Koukoulis, George N. Dalekos

Differential diagnosis of autoimmune hepatitis (AIH) incorporates various liver diseases, including alcoholic liver disease (ALD). We report on clinical, laboratory and outcome characteristics of AIH... more

Non-retrieved inferior vena cava filters: causes and long-term follow-up

6 January 2021
Author(s): Jesús Ribas, Esther Alba, Yuliana Pascual-González, Yolanda Ruíz, Adriana Iriarte, José María Mora-Luján, Joana Valcárcel, Xavier Corbella, Salud Santos, Elena Escalante, Antoni Riera-Mestre

Inferior vena cava (IVC) filters are implantable devices created to trap thrombi from the lower extremities and prevent clinically significant pulmonary embolism (PE). According to guidelines, the... more

Predictors of mortality among adult, old and the oldest old patients with bloodstream infections: An age comparison

4 January 2021
Author(s): Francesca Giovannenze, Rita Murri, Claudia Palazzolo, Francesco Taccari, Marta Camici, Teresa Spanu, Brunella Posteraro, Maurizio Sanguinetti, Roberto Cauda, Graziano Onder, Massimo Fantoni

In recent years, incidence of bloodstream infections (BSIs) has been increasing worldwide, with over 1.2 million estimated episodes of BSI per year in Europe and around 600 000 in North America [1].... more

Long-term outcomes of postoperative atrial fibrillation following non cardiac surgery: A systematic review and metanalysis

2 January 2021
Author(s): Alessandro Albini, Vincenzo Livio Malavasi, Marco Vitolo, Jacopo Francesco Imberti, Marco Marietta, Gregory Y.H. Lip, Giuseppe Boriani

New-onset atrial fibrillation (AF) in non-cardiac postoperative setting is common and is associated with a high risk of in-hospital mortality and morbidity. The long-term risks of stroke, mortality... more

Lung ultrasonography: a prognostic tool in non-ICU hospitalized patients with COVID-19 pneumonia.

2 January 2021
Author(s): Casella Francesco, Barchiesi Marco, Leidi Federica, Russo Giulia, Casazza Giovanni, Valerio Giulia, Torzillo Daniela, Ceriani Elisa, Del Medico Marta, Brambilla Anna Maria, Mazziotti Maria Alessandra, Cogliati Chiara

From February to March 2020, Italy became the most affected country worldwide by coronavirus disease (COVID-19). Our healthcare system was put under enormous pressure, especially in Lombardia which... more

Efficacy and safety of rituximab biosimilar (CT-P10) in IgG4-related disease: an observational prospective open-label cohort study

29 December 2020
Author(s): Emanuel Della-Torre, Marco Lanzillotta, Corrado Campochiaro, Giulia Di-Colo, Gaia Mancuso, Gabriele Capurso, Massimo Falconi, Lorenzo Dagna

IgG4-related disease (IgG4-RD) is an increasingly recognized immune-mediated disorder that can affect almost every organ system and cause severe damage if left untreated [1-5]. Clinical and... more

Prevalence and impact on outcome of sodium and potassium disorders in patients with community-acquired pneumonia: A retrospective analysis

24 December 2020
Author(s): Svenja Ravioli, Rebecca Gygli, Georg-Christian Funk, Aristomenis Exadaktylos, Gregor Lindner

Disorders of serum sodium and potassium are frequently encountered in hospitalized patients and patients presenting to the emergency department (ED) [1, 2].

Cardiac involvement in eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): Prospective evaluation at a tertiary referral centre

22 December 2020
Author(s): Mattia Zampieri, Giacomo Emmi, Matteo Beltrami, Carlo Fumagalli, Maria Letizia Urban, Lorenzo-Lupo Dei, Alberto Marchi, Martina Berteotti, Alessia Tomberli, Katia Baldini, Alessandra Bettiol, Silvia Pradella, Elena Silvestri, Niccolò Marchionni, Augusto Vaglio, Iacopo Olivotto, Domenico Prisco

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis. Cardiac specific involvement (CSI) is caused by coronary artery vasculitis, but also by myocardial eosinophilic... more

The Atrial fibrillation Better Care (ABC) pathway and cardiac complications in atrial fibrillation: a potential sex-based difference. The ATHERO-AF study

21 December 2020
Author(s): Daniele Pastori, Danilo Menichelli, Francesco Violi, Pasquale Pignatelli, Gregory Y H Lip, the ATHERO-AF study group

An integrated care approach is recommended to optimize management of patients with atrial fibrillation (AF). The impact of the Atrial fibrillation Better Care (ABC) pathway on major adverse cardiac... more

Neuraminidase inhibitors are effective and safe in reducing influenza complications: meta-analysis of randomized controlled trials.

21 December 2020
Author(s): Sofía Tejada, Miia Jansson, Candela Solé-Lleonart, Jordi Rello

Influenza is an infection of variable severity resulting in high accumulated mortality worldwide [1]. Seasonal influenza deaths occur mainly in young children and the elderly, while during influenza... more

Is there excessive troponin testing in clinical practice? Evidence from emergency medical admissions

19 December 2020
Author(s): Richard Conway, Declan Byrne, Seán Cournane, Deirdre O'Riordan, Seamus Coveney, Bernard Silke

Troponin assays are a relatively common laboratory diagnostic request in emergency medical admissions. Following cardiac injury these macromolecules diffuse into the cardiac interstitium with... more

Negligible HCC risk during stringently defined untreated immune-tolerant phase of chronic hepatitis B

4 December 2020
Author(s): Hye Won Lee, Young Eun Chon, Beom Kyung Kim, Terry Cheuk-Fung Yip, Yee-Kit Tse, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Henry Lik-Yuen Chan, Sang Hoon Ahn

Among patients with chronic hepatitis B (CHB), a persistently high serum hepatitis B virus (HBV)-DNA level, a surrogate marker of active HBV replication in hepatocytes, is associated with an... more

The effect of COPD on the incidence and mortality of hospitalized patients with pulmonary embolism: A nationwide population-based study (2016-2018)

26 November 2020
Author(s): Javier de-Miguel-Diez, Romana Albaladejo-Vicente, Rodrigo Jiménez-García, Valentín Hernandez-Barrera, Rosa Villanueva-Orbaiz, David Carabantes-Alarcon, David Jimenez, Manuel Monreal, Ana López-de-Andrés

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in the world. It affects more than 10% of people over 40 years old and is expected to become the third leading... more

Home FIRsT: interdisciplinary geriatric assessment and disposition outcomes in the Emergency Department

24 November 2020
Author(s): Íde O'Shaughnessy, Roman Romero-Ortuno, Lucinda Edge, Aoife Dillon, Sinéad Flynn, Robert Briggs, Darragh Shields, Geraldine McMahon, Arthur Hennessy, Una Kennedy, Paul Staunton, Rosa McNamara, Suzanne Timmons, Frances Horgan, Conal Cunningham

With population ageing worldwide, the numbers of older people attending Emergency Departments (ED) continue to increase, which may lead to adverse operational and patient outcomes. [1] Older people... more

Non-classical clinical presentation at diagnosis by male celiac disease patients of older age

17 November 2020
Author(s): Ineke L. Tan, Sebo Withoff, Jeroen J. Kolkman, Cisca Wijmenga, Rinse K. Weersma, Marijn C. Visschedijk

Celiac disease (CeD) is a complex immune-mediated disease that occurs in ̴1–2% of the Caucasian population [1]. In patients with CeD, ingestion of gluten peptides that are present in barley, wheat... more

Long-term recurrence risk after a first venous thromboembolism in men and women under 50 years old: A French prospective cohort

16 November 2020
Author(s): Claire de Moreuil, Raphael Le Mao, Emmanuelle Le Moigne, Brigitte Pan-Petesch, Cécile Tromeur, Clément Hoffmann, Pierre-Yves Salaun, Michel Nonent, Marc Danguy des Déserts, Xavier Savary, Marie Guegan, Elise Poulhazan, Christophe Leroyer, Karine Lacut, Francis Couturaud

Venous thromboembolism (VTE) is a frequent and potentially life-threatening disease. Beyond the initial three months of anticoagulation, it is essential to evaluate accurately the recurrence risk of... more

Serum levels of C-terminal FGF23 (cFGF23) are associated with 1-year-mortality in patients undergoing transcatheter aortic valve replacement (TAVR)

13 November 2020
Author(s): Moritz Mirna, Alexander Lauten, Peter Jirak, Richard Rezar, Bernhard Wernly, Vera Paar, Thomas K. Felder, Uta C. Hoppe, Lukas J. Motloch, Christian Jung, Brunilda Alushi, Michael Lichtenauer, Hermann Salmhofer

The family of fibroblast growth factors (FGFs) was discovered in 1975 [1] and has since been investigated in numerous scientific studies. The FGFs comprise a group of 22 small polypeptides (... more

Prevalence, risk factors and proteomic bioprofiles associated with heart failure in rheumatoid arthritis: The RA-HF study

7 November 2020
Author(s): Maria Betânia Ferreira, Tomás Fonseca, Rita Costa, António Marinhoc, Henrique Cyrne Carvalho, José Carlos Oliveira, Faiez Zannad, Patrick Rossignol, Jacques-Eric Gottenberg, Francisca A. Saraiva, Patrícia Rodrigues, António S. Barros, João Pedro Ferreira

Rheumatoid Arthritis (RA) is a systemic chronic and progressive inflammatory disease, characterized by persistent synovitis and joint erosion [1]. It affects around 1% of the general population and... more

Hypernatremia and moderate-to-severe hyponatremia are independent predictors of mortality in septic patients at emergency department presentation: A sub-group analysis of the need-speed trial

5 November 2020
Author(s): Luigi Mario Castello, Francesco Gavelli, Marco Baldrighi, Livia Salmi, Filippo Mearelli, Nicola Fiotti, Filippo Patrucco, Mattia Bellan, Pier Paolo Sainaghi, Giulia Ronzoni, Salvatore Di Somma, Enrico Lupia, Maria Lorenza Muiesan, Gianni Biolo, Gian Carlo Avanzi

Early risk stratification of septic patients admitted to the Emergency Department (ED) is challenging [1,2] since signs and symptoms may be similar for patients who will have either a favorable or an... more

Interleukin-6 receptor blockade with subcutaneous tocilizumab improves coagulation activity in patients with COVID-19

3 November 2020
Author(s): Marcello Di Nisio, Nicola Potere, Matteo Candeloro, Antonella Spacone, Leonardo Pieramati, Giovanna Ferrandu, Giulia Rizzo, Matteo La Vella, Silvio Di Carlo, Donatella Cibelli, Giustino Parruti, Marcel Levi, Ettore Porreca

A considerable proportion of patients with Coronavirus Disease 2019 (COVID-19) presents with a hypercoagulable state which may increase the risk of thromboembolic complications [1]. The most typical... more

Pre-operative physical performance as a predictor of in-hospital outcomes in older patients undergoing elective cardiac surgery

31 October 2020
Author(s): Samuele Baldasseroni, Alessandra Pratesi, Pierluigi Stefàno, Stefano Del Pace, Valter Campagnolo, Anna Chiara Baroncini, Aldo Lo Forte, Andrea Giosafat Marella, Andrea Ungar, Mauro Di Bari, Niccolò Marchionni, Italian Society of Geriatric Cardiology (SICGe)

Improved surgical techniques and intensive care management have dramatically reduced perioperative complications and mortality after cardiac surgery over the last two decades [1]. Therefore,... more

Serum uric acid and mortality thresholds among men and women in the Irish health system: A cohort study

19 October 2020
Author(s): Leonard D. Browne, Fatima-Zahra Jaouimaa, Cathal Walsh, Fernando Perez-Ruiz, Paschal Richette, Kevin Burke, Austin G. Stack

It is widely considered that serum uric acid (SUA), the final breakdown product of purine metabolism in humans, may represent a major cardiovascular risk factor and contribute to adverse health... more

Mobile health technology-supported atrial fibrillation screening and integrated care: A report from the mAFA-II trial Long-term Extension Cohort

13 October 2020
Author(s): Yutao Guo, Jun Guo, Xiangmin Shi, Yuan Yao, Yihong Sun, Yunlong Xia, Bo Yu, Tong Liu, Yundai Chen, Gregory Y H Lip, mAF-App II Trial investigators

The priorities of atrial fibrillation management include stroke prevention, decisions on rate or rhythm control and proactive management of comorbidities, as well as lifestyle changes. Given that... more

Sex-specific outcomes and management in critically ill septic patients

12 October 2020
Author(s): Bernhard Wernly, Raphael Romano Bruno, Behrooz Mamandipoor, Christian Jung, Venet Osmani

Sepsis is a life-threatening condition triggered by an “out-of-proportion” immune response to an infection [1]. Septic patients have low survival rates, and research to refine and individualize... more

Enterococcal infective endocarditis is a marker of current occult or future incident colorectal neoplasia

9 October 2020
Author(s): Maria Paola Ursi, Lorenzo Bertolino, Roberto Andini, Fabiana D'Amico, Domenico Iossa, Arta Karruli, Eugenio D'Avenia, Sabrina Manduca, Mariano Bernardo, Rosa Zampino, Emanuele Durante-Mangoni

Streptococcus gallolyticus and Enterococcus species are members of the gut microbiota and a major cause of infective endocarditis (IE), mainly affecting elderly subjects with digestive or urinary... more

Trends and outcomes of device-related 30-day readmissions after left ventricular assist device implantation

7 October 2020
Author(s): Alexandros Briasoulis, Hiroki Ueyama, Toshiki Kuno, Rabea Asleh, Paulino Alvarez, Aaqib H Malik

Newer generation, continuous-flow left ventricular assist devices (LVAD) have been introduced for use in end-stage heart failure as a bridge to transplant therapy or destination therapy, leading to... more

Consumer-led screening for atrial fibrillation using consumer-facing wearables, devices and apps: A survey of health care professionals by AF-SCREEN international collaboration

12 September 2020
Author(s): Giuseppe Boriani, Renate B Schnabel, Jeff S Healey, Renato D Lopes, Nicole Verbiest-van Gurp, Trudie Lobban, John A Camm, Ben Freedman

Atrial fibrillation (AF) is the most common sustained arrhythmia diagnosed in clinical practice, with an incidence that increases in the elderly [1,2] and a prevalence of diagnosed AF that is... more

Seventeen-year trend (2001–2017) in pacemaker and implantable cardioverter-defibrillator utilization based on hospital discharge database data: An analysis by age groups

12 September 2020
Author(s): Massimo Zecchin, Marina Torre, Eugenio Carrani, Letizia Sampaolo, Enrico Ciminello, Benedetta Ortis, Renato Ricci, Alessandro Proclemer, Gianfranco Sinagra, Giuseppe Boriani

National Registries are needed to monitor health care interventions, optimize the resources and utilize them appropriately [1], but are challenging to implement and manage due to the possible lack... more

Long-term effects of non-retrieved inferior vena cava filters on recurrences of venous thromboembolism in cancer and non-cancer patients: From the COMMAND VTE registry

10 September 2020
Author(s): Toru Takase, Yoshitaka Iwanaga, Yugo Yamashita, Takeshi Morimoto, Yusuke Yoshikawa, Hidewo Amano, Seiichi Hiramori, Kitae Kim, Maki Oi, Yohei Kobayashi, Yuji Nishimoto, Heitaro Watanabe, Kenji Yamaji, Ryobun Yasuoka, Masafumi Ueno, Kazuhiro Kobuke, Takeshi Kimura, Shunichi Miyazaki, COMMAND VTE Registry Investigators

There is a paucity of data comparing the long-term outcomes after inferior vena cava (IVC) filters placement for patients with acute venous thromboembolism (VTE) between those with and without active... more

Baseline and incident hypochloremia in chronic heart failure outpatients: Clinical correlates and prognostic role

5 September 2020
Author(s): Maria Consiglia Bellino, Francesco Massari, Miriam Albanese, Raffaella Ursi, Gianmarco Angelini, Francesco Lisi, Luca Amato, Pietro Scicchitano, Pietro Guida, Natale Daniele Brunetti, Francesca Di Serio, Marco Matteo Ciccone, Massimo Iacoviello

Abnormalities in serum electrolyte levels often complicate heart failure (HF) disease in acute (ADHF) and chronic (CHF) settings. Serum sodium has long been considered the most important electrolyte... more

Impact of non-selective ß-blockers on hepatic encephalopathy in patients with liver cirrhosis

29 August 2020
Author(s): Christian Labenz, Michael Nagel, Gerrit Toenges, Robert Kuchen, Jörn M. Schattenberg, Max Hilscher, Yvonne Huber, Jens U. Marquardt, Joachim Labenz, Peter R. Galle, Marcus-Alexander Wörns

Liver cirrhosis accounts for over one million deaths per year worldwide [1]. Hepatic encephalopathy (HE) - one of its most severe complications - is a brain dysfunction mainly caused by liver... more

Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study

25 August 2020
Author(s): The COVID-19 RISK and Treatments (CORIST) Collaboration

Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19.

Definition of tachycardia for risk stratification of pulmonary embolism

23 August 2020
Author(s): Lukas Hobohm, Cecilia Becattini, Matthias Ebner, Markus H. Lerchbaumer, Franco Casazza, Gerd Hasenfuß, Stavros V. Konstantinides, Mareike Lankeit

Acute pulmonary embolism (PE) is the most serious manifestation of venous thromboembolism (VTE) and a major cause of mortality, morbidity and hospitalization in Western countries [1]. Acute right... more

Gastric regurgitation predicts neurological outcome in out-of-hospital cardiac arrest survivors

22 August 2020
Author(s): Anton Früh, Georg Goliasch, Raphael Wurm, Henrike Arfsten, Stefan Seidel, Lukas Galli, Lukas Kriechbaumer, Pia Hubner, Gottfried Heinz, Fritz Sterz, Christopher Adlbrecht, Klaus Distelmaier

Neurological prognostication after out-of-hospital cardiac arrest (OHCA) is challenging due to the lack of early and reliable predictors for clinically relevant brain damage [1]. The identification... more

Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study

21 August 2020
Author(s): I Mikolasevic, V Domislovic, T Turk Wensveen, B Delija, M Klapan, T Juric, A Lukic, A Mijic, N Skenderevic, P Puz, A Ostojic, Z Krznaric, D Radic-Kristo, T Filipec Kanizaj, D Stimac

The number of people suffering from type 2 diabetes (T2DM) and obesity around the world has significantly increased during the past several decades due to changes in eating habits and sedentary... more

Prognostic impact of Vitamin D deficiency in patients with coronary artery disease undergoing percutaneous coronary intervention

20 August 2020
Author(s): Monica Verdoia, Matteo Nardin, Roberta Rolla, Federica Negro, Rocco Gioscia, Arraa Maddalena Saghir Afifeh, Filippo Viglione, Harry Suryapranata, Marco Marcolongo, Giuseppe De Luca, Novara Atherosclerosis Study Group (NAS)

Vitamin D (25(OH)D) is a fat-soluble vitamin, representing not only the principal modulator of calcium and bone homeostasis, but also a key-hormone, regulating the transcription of about 2000 to 8000... more

How many urinalysis and urine cultures are necessary?

20 August 2020
Author(s): Bart J. Laan, Tessa M.Z.X.K. van Horrik, Prabath W.B. Nanayakkara, Suzanne E. Geerlings

Low-value care is defined as a test or treatment that is unlikely to benefit the patient given the cost, available alternatives, and preferences of patients, [1] and can even cause harm to patients [... more

ETNA VTE Europe: A contemporary snapshot of patients treated with edoxaban in clinical practice across eight European countries

18 August 2020
Author(s): Alexander T. Cohen, Ulrich Hoffmann, Philippe Hainaut, Sean Gaine, Cihan Ay, Michiel Coppens, Marc Schindewolf, David Jimenez, Bernd Brüggenjürgen, Pierre Levy, Petra Laeis, Eva-Maria Fronk, Wolfgang Zierhut, Thomas Malzer, Marius Constantin Manu, Paul-Egbert Reimitz, Peter Bramlage, Giancarlo Agnelli, ETNA-VTE-Europe investigators

Venous thromboembolism (VTE) encompasses both deep vein thrombosis (DVT) and pulmonary embolism (PE). It has an incidence of approximately 1–2 per 1,000 person-years in Europe [1]. While both events... more

Pharmacist-driven medication recognition/ reconciliation in older medical patients

7 August 2020
Author(s): Maria Teresa Chiarelli, Stefania Antoniazzi, Laura Cortesi, Luca Pasina, Alessio Novella, Francesca Venturini, Alessandro Nobili, Pier Mannuccio Mannucci, the ad hoc Deprescribing Study Group

Older patients, the largest fraction of those acutely admitted to hospital medical wards, are often affected by multiple chronic diseases, that are in turn associated with the intake of multiple... more

Low Creatinine Potentially Overestimates Glomerular Filtration Rate in Older Fracture Patients: A Plea for an Extensive Use of Cystatin C?

25 July 2020
Author(s): Iacopo Iacomelli, Antonella Giordano, Giulia Rivasi, Martina Rafanelli, Virginia Tortù, Alessandro Cartei, Carlo Rostagno, Mauro Di Bari, Niccolò Marchionni, Enrico Mossello, Andrea Ungar

The correct evaluation of renal function is crucial in clinical practice for diagnosis (e.g., imaging with contrast agents), treatment (e.g., drug dosing) and prognostic assessment (e.g., clinical... more

Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome

22 July 2020
Author(s): Marco Centola, Alessandro Maloberti, Diego Castini, Simone Persampieri, Ludovico Sabatelli, Giulia Ferrante, Stefano Lucreziotti, Nuccia Morici, Alice Sacco, Fabrizio Oliva, Paola Rebora, Cristina Giannattasio, Antonio Mafrici, Stefano Carugo

High levels of serum uric acid (SUA) have been showed to increase the risk of cardiac adverse events, independently of traditional cardiovascular risk factors [1,2]. Hyperuricemia has been also... more

The CHA2DS2-VASc score and Geriatric Multidimensional Assessment tools in elderly patients with persistent atrial fibrillation undergoing electrical cardioversion. A link with arrhythmia relapse?

22 July 2020
Author(s): Stefano Fumagalli, Giulia Pelagalli, Riccardo Franci Montorzi, Irene Marozzi, Marta Migliorini, Maria Flora D'Andria, Gregory Y.H. Lip, Niccolò Marchionni

The CHA2DS2-VASc is a clinical score used in everyday clinical practice to evaluate thrombo-embolic risk in patients with atrial fibrillation (AF) [1], and the guidelines for the management of AF... more


Multiparametric assessment of “fluid status” in heart failure

15 November 2017
Author(s): Giuseppe Romano, Diego Bellavia, Francesco Clemenza

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.ejim.2017.09.016. The duplicate article has therefore... more

Review Article

Mechanisms of weight regain.

16 January 2021
Author(s): Luca Busetto, Silvia Bettini, Janine Makaronidis, Carl A. Roberts, Jason C.G. Halford, Rachel L. Batterham

Obesity is a chronic progressive disease with a high tendency to recidivism. Weight regain is frequent after any attempts of voluntary weight loss [1]. Weight regain is frequently attributed to the... more

The Brain-Gut-Microbiotal Axis: A framework for understanding functional GI illness and their therapeutic interventions

7 January 2021
Author(s): Christopher Tait, Gregory S. Sayuk

At the core of the BGA is a bidirectional network of communication between the central nervous system (CNS-brain, spinal cord) and the sensory and effector nerve complexes of the GI tract (Figure 1... more

Gastroprotection in patients on antiplatelet and/or anticoagulant therapy: a position paper of National Association of Hospital Cardiologists (ANMCO) and the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO)

2 December 2020
Author(s): Maurizio Giuseppe Abrignani, Luigi Gatta, Domenico Gabrielli, Giuseppe Milazzo, Vincenzo De Francesco, Leonardo De Luca, Maura Francese, Massimo Imazio, Elisabetta Riccio, Roberta Rossini, Fortunato Scotto di Uccio, Marco Soncini, Angelo Zullo, Furio Colivicchi, Andrea Di Lenarda, Michele Massimo Gulizia, Fabio Monica

Aspirin and P2Y12 receptor antagonists are widely used across the spectrum of cardiovascular and cerebrovascular diseases. Gastrointestinal complications, including ulcer and bleeding, are relatively... more

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

30 November 2020
Author(s): Annemieke Smorenberg, Edgar JG Peters, Paul LA van Daele, Esther J Nossent, Majon Muller

On November 18th 2020, there have been over 55 million confirmed cases of SARS-CoV-2 infection causing COVID-19, with up to 1.3 million deaths worldwide. In the Netherlands alone, there are up to 8,... more

Transthyretin amyloid cardiomyopathy: An uncharted territory awaiting discovery

5 October 2020
Author(s): Aldostefano Porcari, Marco Merlo, Claudio Rapezzi, Gianfranco Sinagra

Amyloidosis represents a largely unexplored field in medicine, with many grey areas remaining. The search for the mechanism triggering protein misfolding has been an important research topic for many... more

Incidence of acute pulmonary embolism in COVID-19 patients: Systematic review and meta-analysis.

17 September 2020
Author(s): Loris Roncon, Marco Zuin, Stefano Barco, Luca Valerio, Giovanni Zuliani, Pietro Zonzin, Stavros V Konstantinides

The outbreak of coronavirus disease 2019 (COVID-19) remains a severe public health emergency of international concern. Over the past months, several investigations have suggested an association... more


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