Published: 3 November 2020
Author(s): Riccardo Cappato, Mauro Chiarito, Michela Giustozzi, Martina Briani, Hussam Ali, Letizia Riva, Gianluca Bonitta, Corrado Lodigiani, Francesco Furlanello, Cristina Balla, Pierpaolo Lupo, Giulio Stefanini
Issue: January 2021

Anti-thrombotic and anti-coagulation effects of direct oral anticoagulants (DOACs) are dose-dependent [1–5]. Conversely, the benefit from higher dose DOACs is counterbalanced by a dose-dependent risk of bleeding [4]. Currently recommended regimens are the result of pre-clinical [5,6] and phase III studies [1,2,7–12] in which various doses of DOACs were investigated and compared to standard of care in various conditions such as acute or stable coronary artery disease (CAD), peripheral artery disease (PAD), non-valvular atrial fibrillation (AF), and venous thromboembolism (VTE).


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