High levels of serum uric acid (SUA) have been showed to increase the risk of cardiac adverse events, independently of traditional cardiovascular risk factors [1,2]. Hyperuricemia has been also associated with high mortality rates in patients with acute myocardial infarction (AMI) [3]. However, the relationship between SUA and cardiovascular diseases is not fully elucidated [4]. In particular the role and the prognostic relevance of increased SUA in patients with acute coronary syndrome (ACS) are still under debate [5–7].