Early risk stratification of septic patients admitted to the Emergency Department (ED) is challenging [1,2] since signs and symptoms may be similar for patients who will have either a favorable or an adverse outcome. Among the strategies to detect patients at higher risk, some propose the clinical evaluation of tissue perfusion [3,4], whereas other focus on early signs of circulatory failure [5,6]. Again, the increase in many serum biomarkers levels, such as lactate, could alert to the need for aggressive resuscitative management.
