Published: 12 November 2021
Author(s): Benoit Guery, Matthaios Papadimitriou-Olivgeris
Issue: January 2022

In the vast majority of infectious diseases, the primary endpoint to evaluate an intervention relies on short terms variables and, when relevant, in-hospital mortality, or 28 days mortality. In most cases, these early targets are directly related to an intervention but could potentially fail to estimate a more global approach where other factors could modulate long-term prognosis. This problem was largely evaluated in sepsis survivors, although still largely debated, short prognosis has been related to corticoids [1], early goal-directed therapy [2], or delay in antibiotic administration [3–6].

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