January 2022

53 Articles

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Diagnosis is a probabilistic estimate of disease. A dynamic approach to diminish resource overuse

11 December 2021
Author(s): António Vaz Carneiro

Clinical reasoning (mostly diagnostic reasoning) is made of two sequential steps: firstly, problem-solving - estimating disease probabilities through information from the physical exam and sequential... more

Associations of Post-Acute COVID syndrome with physiological and clinical measures 10 months after hospitalization in patients of the first wave

25 November 2021
Author(s): Anna Staudt, Rudolf A. Jörres, Thilo Hinterberger, Nadine Lehnen, Thomas Loew, Stephan Budweiser

Since the beginning of the COVID-19 pandemic in 2020, in Germany almost 3.8 million inhabitants have been positively tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1], and... more

Infective endocarditis, is there a goal beyond antibiotics and surgery?

12 November 2021
Author(s): Benoit Guery, Matthaios Papadimitriou-Olivgeris

In the vast majority of infectious diseases, the primary endpoint to evaluate an intervention relies on short terms variables and, when relevant, in-hospital mortality, or 28 days mortality. In most... more

Optimal duration of anticoagulation therapy for venous thromboembolism in autoimmune diseases

9 November 2021
Author(s): Yugo Yamashita, Takeshi Morimoto, Takeshi Kimura

Venous thromboembolism (VTE) is a common issue in patients with autoimmune diseases. One of the clinically relevant issues for VTE in autoimmune disorders is the optimal duration of anticoagulation... more

Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year?

26 October 2021
Author(s): Augusto Di Castelnuovo, Simona Costanzo, Alessandro Gialluisi, Licia Iacoviello, Giovanni de Gaetano

The results presently available from randomised clinical trials and their meta-analysis indicate that Hydroxychloroquine is not associated in COVID-19 patients with either decreased mortality or... more

Serum IgG4 elevation in hyper-inflamed COVID-19 patients. Author's reply

21 October 2021
Author(s): Emanuel Della-Torre, Marco Lanzillotta, Giuseppe Alvise Ramirez, Lorenzo Dagna, Moreno Tresoldi

Dear Editor, we thank Dulak and Trzciński for their insightful and pertinent comments on our observation about serum IgG4 levels predicting mortality in hospitalized patients affected by Coron