July 2023

30 Articles

Clinical Insights

MiRNA: what clinicians need to know

20 May 2023
Author(s): Maria Venneri, Andrea Passantino

MiRNAs. MicroRNAs (miRNA) are small non-coding RNAs, approximately 18–24 nucleotides in length, that negatively regulate gene expression either by inhibiting messenger RNA (mRNA) translation or by... more

Is the competition between variants the end of severe acute respiratory syndrome coronavirus 2 pandemic? A journey from Wuhan to XBB.1.16

19 April 2023
Author(s): Martina Zappa, Paolo Verdecchia, Fabio Angeli

The World Health Organisation (WHO) estimated 780 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and approximately 6.9 million deaths related to coronavirus disease... more

Xanthine oxidase inhibition and cardiovascular protection: Don't shoot in the dark

12 April 2023
Author(s): Giovambattista Desideri, Claudio Borghi

Substantial evidence suggests that chronic hyperuricemia is an independent risk factor for hypertension, metabolic syndrome, chronic kidney disease and cardiovascular disease [1,2]. However, whether... more


Using the 4S-AF scheme to characterize new-onset atrial fibrillation after myocardial infarction

9 May 2023
Author(s): James Dunlop, Tatjana Potpara, Gregory Y.H. Lip

There have been many recent advances in the management of atrial fibrillation (AF) and AF-related complications, and current guidelines advocate a structured management pathway that promotes a... more

Extended prophylaxis for venous thromboembolism: A step forward or a step back?

6 May 2023
Author(s): Claudio Cimminiello, Patrizia Boracchi

In this issue of European Journal of Internal Medicine, Wang et al. present their meta-analysis on extended thromboprophylaxis of venous thromboembolism (VTE) in medical patients [1]. To comment on... more

Routine measurement of DOAC concentrations for prognostication and clinical management in acute ischemic stroke: Is it ready for prime time?

29 April 2023
Author(s): Stephanie Carlin, Noel C. Chan, James D. Douketis

When used in fixed doses for stroke prevention in atrial fibrillation (SPAF) and for the prevention and treatment of venous thromboembolism (VTE), direct oral anticoagulants (DOACs), including... more

Internal Medicine Flashcard

Yellow-Tinted Dialysis Drainage

19 March 2023
Author(s): Masatoshi Inoue

A 69-year-old woman, with end-stage renal disease and in a hemodialysis program for 11 years, presented to a dialysis treatment center for maintenance hemodialysis without symptoms. We started... more

Peculiar genital lesions

15 March 2023
Author(s): Govind Srivastava, Gautam Srivastava

A 25-year-old university student presented with a 3-day history of malaise, sore throat, and one-day history of skin lesions on the penis with isolated lesions on the arms and palms. He has a history... more

Internal Medicine Flashcards

Multiple pulmonary opacities. An alarming sign?

13 March 2023
Author(s): Shay Brikman, Guy Dori

A 60-year-old man with a history of chronic transfusion-dependent β-thalassemia intermedia, splenectomy and secondary hemochromatosis was admitted due to one week of fever and non-respiratory... more

Letter to the Editor

Competition between variants and SARS-Co-V2 epidemic, from Wuhan to XBB.1.16.: Natural selection?

9 May 2023
Author(s): Amnuay Kleebayoon, Viroj Wiwanitkit

We would like to share some ideas on the article “Is the competition between variants the end of severe acute respiratory syndrome coronavirus 2 pandemic? A journey from Wuhan to XBB.1.16 [1].”... more

Hypertension and myocarditis following COVID-19 vaccination. Two sides of the coin?

28 April 2023
Author(s): Fabio Angeli, Gianpaolo Reboldi, Martina Zappa, Paolo Verdecchia

The effectiveness of the coronavirus disease 2019 (COVID-19) vaccination program in mitigating COVID-19 outbreaks, even with limited protection against infection, is well established [1,2]. Available... more

Long-term outcome in pulmonary embolism: Is it healthy to be lean?

23 April 2023
Author(s): Ivana Jurin, Marin Pavlov, Sime Manola, Tomislav Letilovic, Irzal Hadzibegovic

Body mass index

Recent cancer history and its impact on cardiovascular outcomes and mortality after an incident ischemic stroke

21 April 2023
Author(s): Hirofumi Kanazawa, Tomonari Shimoda, Yui Okamura, Noriaki Kou, Hiroshi Ito

Dear Editor,

Risk factors for adverse events in first-line Helicobacter pylori eradication therapy with vonoprazan, amoxicillin, and clarithromycin

2 April 2023
Author(s): Yusaku Kajihara

Vonoprazan is an oral potassium-competitive acid blocker that has a greater acid-inhibitory effect than proton pump inhibitors (PPIs). Many studies have shown that vonoprazan-based triple therapy had... more

Differences in reporting of adverse drug reactions due to COVID-19 vaccines depending on the reporter

21 March 2023
Author(s): Alfredo Jose Pardo-Cabello, Victoria Manzano-Gamero, Juan de Dios Luna

The pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 provoked the rapid generation and mass production of vaccines against the virus. In this serious situation, the European... more

Characteristics and trends of publications in the European Journal of Internal Medicine

19 March 2023
Author(s): Thomas Gamstaetter

Scientific journals play a central role in informing the science and practice of Internal Medicine, in particular through the publication of clinical trials and systematic reviews [1]. The relevancy... more

Original Article

A systematic review and meta-analysis of all sham and placebo controlled trials for resistant hypertension

5 May 2023
Author(s): Mohammad Ahmed, Matthew Nudy, Rahul Bussa, Edward J. Filippone, Andrew J. Foy

Patients who have uncontrolled blood pressure (BP) despite being on maximally tolerated doses of 3 antihypertensive medications of different classes (one of which must be a diuretic) or who are... more

The Influence of baseline glycemic status on the effects of intensive blood pressure lowering: Results from the STEP randomized trial

2 May 2023
Author(s): Ruixue Yang, Yixuan Wang, Anli Tong, Jing Yu, Dechao Zhao, Jun Cai

Hypertension is a major risk factor for cardiovascular diseases. However, low awareness, treatment, and control rates are increasing the global health burden of hypertension [1,2]. Comorbidities are... more

Comparison of benzbromarone and allopurinol on the risk of chronic kidney disease in people with asymptomatic hyperuricemia

29 April 2023
Author(s): Shih-Wei Lai, Kuan-Fu Liao, Yu-Hung Kuo, Bing-Fang Hwang, Chiu-Shong Liu

The objective of the study was to compare the relative effects of benzbromarone and allopurinol on the risk of developing chronic kidney disease in persons with asymptomatic hyperuricemia.

Sources of primary bloodstream infections in internal medicine patients – a cohort study

26 April 2023
Author(s): Shmuel Benenson, Yonatan Ben-Yosef, Carmela Schwartz, Matan J Cohen, Yonatan Oster

Bloodstream infection (BSI) is a common diagnosis in hospitalized patients causing significant morbidity and mortality [1–2]. In a comprehensive review from a large tertiary center, its incidence... more

High miR-126-3p levels associated with cardiovascular events in a general population

18 April 2023
Author(s): Olga Martinez-Arroyo, Ana Ortega, Ana Flores-Chova, Belen Sanchez-Garcia, Ana B Garcia-Garcia, Felipe J Chaves, Juan C Martin-Escudero, Maria Jose Forner, Josep Redon, Raquel Cortes

Endothelial dysfunction is a forerunner in the development of atherosclerosis, cardiovascular (CV) and renal disease [1]. A marker of endothelial dysfunction is an increase in urinary albumin... more

Acute pericarditis with pleuropulmonary involvement, fever and elevated C-reactive protein: A systemic autoinflammatory disease? A cohort study

15 April 2023
Author(s): Anna Maria Pisacreta, Ruggiero Mascolo, Mariangela Nivuori, Costanza Caccia Dominioni, Claudia Gabiati, Lucia Trotta, Massimo Pancrazi, Giacomo Di Marco, Chiara Carollo, Alice Pedroli, Francesca Casarin, Enrico Tombetti, Emanuele Bizzi, Massimo Imazio, Antonio Brucato

Pericardial diseases may be considered either as isolated (more often managed by cardiologists) or as part of a systemic disease, often managed by multidisciplinary teams also including internists,... more

SGLT2 breast expression could affect the cardiovascular performance in pre-menopausal women with fatty vs. non fatty breast via over-inflammation and sirtuins’ down regulation

14 April 2023
Author(s): Celestino Sardu, Gianluca Gatta, Gorizio Pieretti, Nunzia D’ Onofrio, Maria Luisa Balestrieri, Lucia Scisciola, Salvatore Cappabianca, Giuseppe Ferraro, Giovanni Francesco Nicoletti, Giuseppe Signoriello, Liberata Sportiello, Gianluigi Savarese, Mario Melchionna, Feliciano Ciccarelli, Daniele La Forgia, Giuseppe Paolisso, Raffaele Marfella

The cardiovascular diseases (CVDs) in women could be caused by the expression of traditional cardiovascular risk factors [1–3], and specific female-dependent risk factors as menopause [4]. Hence,... more

Prognostic implications of the 4S-AF scheme to characterize new-onset atrial fibrillation after myocardial infarction

8 April 2023
Author(s): Jiachen Luo, Zhiqiang Li, Xiaoming Qin, Xingxu Zhang, Xiangdong Liu, Wenming Zhang, Wei Xu, Yiwei Zhang, Yuan Fang, Baoxin Liu, Yidong Wei, NOAFCAMI-SH Registry Investigators

New-onset atrial fibrillation (NOAF) is a common finding during the acute phase of acute myocardial infarction (AMI) with an incidence rate ranging from 6% to 21% [1]. Although there are numerous... more

Effect of extended duration of thromboprophylaxis for medically ill patients

5 April 2023
Author(s): Xing Wang, Yuqi Chen, Dingke Wen, Chao You, Lu Ma

Patients hospitalized for acute medical illnesses such as stroke, infections, heart attack, and COVID-19 are at increased risk for venous thromboembolism [1–3]. The situation is even worse in... more

The association between direct oral anticoagulant concentration upon acute stroke and stroke outcome

27 March 2023
Author(s): Shin-Yi Lin, Sung-Chun Tang, Ching-Hua Kuo, Chih-Hao Chen, Yuan-Chang Chao, Chih-Fen Huang, Jiann-Shing Jeng

Direct oral anticoagulants (DOAC), including dabigatran, rivaroxaban, apixaban, and edoxaban, are commonly used to prevent thromboembolism in various populations. Nevertheless, ischemic stroke (IS)... more

Review Article

Tirzepatide and potential use for metabolically healthy obesity

12 May 2023
Author(s): Sidar Copur, Cem Tanriover, Furkan Yavuz, Katherine R. Tuttle, Mehmet Kanbay

There has been a tripling in the number of individuals with obesity around the globe within the last 50 years [1,2]. As a result, more than 650 million adults are considered obese whereas at least 1.... more


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