Sarcoidosis exemplifies the complexity of modern internal medicine, requiring comprehensive, system-based management. The disease is characterized by non-caseating granulomas and can affect virtually any organ, with pulmonary involvement in over 90 % of patients and extrapulmonary manifestations in up to 70 %. Its heterogeneous spectrum, variable course, and risk of organ damage make early recognition and multidisciplinary collaboration essential.This narrative review outlines the clinical manifestations of sarcoidosis, emphasizing organ-specific and systemic non-organ specific symptoms such as fatigue and small fiber neuropathy, which substantially impair quality of life (QoL).
