An 80-year-old woman with a history of venous thromboembolism and ischemic stroke was admitted with headache and confusion. Examination revealed fever and an altered mental status, but was otherwise unremarkable. Laboratory tests showed normal electrolytes and kidney function and no signs of inflammation. Urine analysis, chest X-ray and imaging of the brain with CT scan showed no explanation for the fever or confusion. Intravenous treatment with cefuroxime 1500mg and gentamycin 350mg was immediately started at admission.