October 2016

35 Articles

No Section

Association between acute kidney injury and risk of Parkinson disease

1 October 2016
Author(s): Shih-Yi Lin, Cheng-Li Lin, Wu-Huei Hsu, Hung-Chieh Yeh, Cheng-Chieh Lin, Chih-Hsueh Lin, Chun-Hung Tseng

Worldwide, the incidence of acute kidney injury (AKI) has been increasing. However, information on the long-term incidence of Parkinson disease (PD) in patients with AKI has not been reported.

Internal Medicine Flashcard

A 77-year-old man with fever and night sweats

17 October 2016
Author(s): Usama A. Daimee, Mark A. Shelly, Steven M. Fine

A 77-year-old man presented to the emergency department with five days of episodic fevers, rigors, and night sweats. He described malaise and low appetite. There was no weight loss, headache, neck... more

T wave alternans: An ominous marker for malignant cardiac arrhythmias

17 October 2016
Author(s): Gurunath Parale, Chinmay Parale

60yr old lady presented with increasing dyspnoea. She had history of anterior myocardial infarction 4yrs. ago. Her admission EKG revealed a peculiar abnormality during repolarisation.

Large subcutaneous tumor of the left shoulder

15 October 2016
Author(s): José M. Olmos-Martínez, Ana I. Córdoba, José M. Olmos

A 66-year-old, otherwise healthy man presented to our clinic with a large tumor on the left shoulder. The patient reported that the lesion had initially been a small, firm nodule that appeared six... more

Prolonged P wave with biphasic morphology in the inferior leads

15 October 2016
Author(s): Francisco José Fernández-Fernández

A 68-year-old woman was admitted to the hospital with fever, progressive dyspnea, and cough productive of white sputum. The patient's history included type 2 diabetes mellitus, hypertension, and... more

Isolated hand weakness

14 October 2016
Author(s): Guan Sen Kew, Vijay K. Sharma, Jonathan J.Y. Ong

A 63-year old man, with a past medical history of hypertension and dyslipidemia, presented with a one-day history of isolated left-hand weakness of sudden onset. Neurological examination revealed a... more

Hypotension with scrotal and penile ecchymoses

12 October 2016
Author(s): Zhe Li, Andrew Smaggus

A 61-year-old man with a history of end stage renal disease (requiring intermittent hemodialysis) presented to the hospital with hypotension, tachycardia and decreased level of consciousness. A... more

A rare cause of intractable diarrhea

12 October 2016
Author(s): Alessandro Gualerzi, Mattia Bellan, Mario Pirisi

An 81-year old man was admitted to an Internal Medicine Division because of severe watery diarrhea lasting 8months, unresponsive to fasting and to a gluten-free diet. Since the onset of symptoms he... more

Acute kidney injury: Finding a needle in a haystack

10 October 2016
Author(s): Fouad Amraoui, Sander W.M. Keet, Niels H. Schut

An 80-year-old woman with a history of venous thromboembolism and ischemic stroke was admitted with headache and confusion. Examination revealed fever and an altered mental status, but was otherwise... more

Did we do something wrong?

10 October 2016
Author(s): Abhilash Koratala, Vikrampal Bhatti

A 64-year-old male was brought to the hospital for evaluation of weight loss, inability to eat, and coughing with copious oral secretions. He had a history of squamous cell carcinoma of the right... more

Letter to the Editor

Use of non-steroidal anti-inflammatory drugs and analgesics in a cohort of hospitalized elderly patients: Results from the REPOSI study

29 October 2016
Author(s): Luca Pasina, Laura Cortesi, Mauro Tettamanti, Alessandro Nobili, Pier Mannuccio Mannucci, REPOSI Investigators

Pain in the elderly is associated with substantial disability stemming from reduced mobility, avoidance of activity, falls, depression, anxiety, sleep impairment and isolation [1–3]. Pharmacological... more

The Italian plan of the chronicity: Where is the internist?

29 October 2016
Author(s): F. Fiammengo, A. Perciaccante

The Italian Health Minister recently elaborated the “national plan of the chronicity”, a document which governs the care and the protection of the patients suffering from chronic diseases [1]. The... more

Association between anthropometric indices and hyperuricemia in rural area of China: Methodological issues

28 October 2016
Author(s): Saeid Safiri, Mohadeseh Sani, Erfan Ayubi

We read with great interest the currently published manuscript written by Zhang N et al. [1] entitled “A Body Shape Index and Body Roundness Index: Two new body indices for detecting association... more

Use of the citizen's electronic health record by doctors and patients in a mature application throughout a district of the national health system of Italy

18 October 2016
Author(s): Nando Campanella, Sandro Novelli, Pierpaolo Morosini, Guido Sampaolo

In the Unified and Universal Health Systems of Western Europe countries and Brazil, the Electronic Health Record (EHR) is an important item within the e-health national agendas for strengthening the... more

Leonardo teaching anatomy and psychology to Raffaello and Michelangelo

15 October 2016
Author(s): Antonio V Sterpetti, Enrico Fiori, Marco Ventura

Leonardo, Raffaello and Michelangelo were the promoters of a new form of art; a universal art, above the horizons of the imagination itself. They materialized in images a superior art, where dreams... more

Effects of granulocyte-colony stimulating factor (G-CSF) on stem cell mobilization in patients with liver failure

13 October 2016
Author(s): Cornelius Engelmann, Katrin Splith, Thomas Berg, Moritz Schmelzle

Acute liver failure (ALF) as well as acute-on-chronic liver failure (ACLF) in patients with pre-existing chronic liver disease are defined by rapid deterioration of liver function in association with... more

Impact of antiretroviral therapy on mid-and-long term survival among people living with HIV/AIDS in Guangxi, Southern China — A cohort study

11 October 2016
Author(s): Zhigang Zheng, Eric J Nehl, Wenkui Geng, Qin Meng, Qiuying Zhu

The study included 10,726 people living with HIV/AIDS, of which 5735 (53.6%) individuals had initiated cART and 4991 (46.4%) who were therapy-naïve between 2010 and 2014. Of all patients, the median... more

Imported filariasis in Europe: A series of 31 cases from Metropolitan France

9 October 2016
Author(s): M. Develoux, C. Hennequin, G. Le Loup, L. Paris, D. Magne, G. Belkadi, G. Pialoux

Filariases are diseases caused by parasitic roundworms (nematodes) called filariae [1]. Main infections are onchocerciasis, loiasis and lymphatic filariasis. All are arthropod-borne infections, and... more

PCSK9 inhibitors: A new era in stroke prevention?

8 October 2016
Author(s): Luis Castilla-Guerra, M.C. Fernandez-Moreno

In an interesting paper Milionis et al. [1], aimed to investigate the effect of Proprotein Convertase Subtilisin Kexin 9 (PCSK9) inhibition on stroke risk in a meta-analysis involving data from... more

Splenomegaly and the JAK2 V617F mutation

7 October 2016
Author(s): Stephen E. Langabeer

The classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) comprise the clinically and pathologically related polycythemia vera (PV), essential thrombocythemia (ET) and primary... more

Seasonal variations of incident primary immune thrombocytopenia in adults: An ecological study

7 October 2016
Author(s): Guillaume Moulis, Sophie Guénin, Nicolas Limal, Marc Michel, Philippe Bierling, Bertrand Godeau, Matthieu Mahévas

Thus far, only two studies have investigated seasonal variations of primary immune thrombocytopenia (ITP) incidence in children. Results have shown a temporally correlated increase in ITP incidence... more

Letters to the Editor

Long delay to onset of ACE inhibitors-induced cough: Reason of difficult diagnosis in primary care?

17 October 2016
Author(s): X. Humbert, J. Alexandre, M. Sassier, A. Default, A. Gouraud, M. Yelehe-Okouma, P.E. Puddu, S. Fedrizzi

Angiotensin converting enzyme inhibitors (ACEI) were first introduced in 1981. They are widely used in the field of hypertension, heart failure and kidney dysfunction. In general, ACEI are effective... more

Inadequate reporting of enrolled patient and study site characteristics, and inter-study site differences in randomized controlled trials: A systematic review in six leading medicine journals

5 October 2016
Author(s): Sebahattin Yurdakul, Gizem Ayan, Yesim Ozguler, Gulen Hatemi, Serdal Ugurlu, Emire Seyahi, Hasan Yazici

Randomized controlled trials (RCTs) are the gold standard in assessing the efficacy of any kind of healthcare intervention. A clear, complete, and transparent reporting of the design, conduct, and... more

Narrative Review

Community-acquired pneumonia in adults: Highlighting missed opportunities for vaccination

15 October 2016
Author(s): Francesco Blasi, Murat Akova, Paolo Bonanni, Nathalie Dartois, Evelyne Sauty, Chris Webber, Antoni Torres

Pneumococcal pneumonia remains a clear unmet medical need for adults worldwide. Despite advances in vaccine technology, vaccination coverage remains low, putting many people at risk of significant... more

Original Article

The efficacy advantage of evolocumab (AMG 145) dosed at 140mg every 2weeks versus 420mg every 4weeks in patients with hypercholesterolemia: Evidence from a meta-analysis

27 October 2016
Author(s): Xiao-Xiao He, Rong Zhang, Pei-Yuan Zuo, Yu-Wei Liu, Xiang-Nan Zha, Sheng-Shuai Shan, Cheng-Yun Liu

Evolocumab (AMG 145), a PCSK9 inhibitor, has been shown to decrease low-density lipoprotein cholesterol (LDL-C) levels. Doses of 140mg administered every 2weeks (Q2W) and 420mg administered every... more

Behçet's disease‬ and FMF: Two sides of the same coin or just an association? A cross-sectional study‬

22 October 2016
Author(s): Abdulla Watad, Shmuel Tiosano, Dana Yahav, Doron Comaneshter, Yehuda Shoenfeld, Arnon D. Cohen, Howard Amital

Familial Mediterranean fever (FMF) is a genetic disease, characterized by attacks of fever, arthritis, serositis and pain. Behçet's disease (BD) is an inflammatory disorder with a genetic basis,... more

The quality of the reported sample size calculations in randomized controlled trials indexed in PubMed

18 October 2016
Author(s): Paul H. Lee, Andy C.Y. Tse

There are limited data on the quality of reporting of information essential for replication of the calculation as well as the accuracy of the sample size calculation. We examine the current quality... more

CRONIGAL: Prognostic index for chronic patients after hospital admission

10 October 2016
Author(s): Javier Suárez Dono, Evelín Cervantes Pérez, Marta Pena Seijo, Francisco Formigo Couceiro, Fernando Ferrón Vidán, Ignacio Novo Veleiro, Esther Del Corral Beamonte, Jesús Díez Manglano, Francisco Gude Sampedro, Antonio Pose Reino

We have followed patients admitted to a Polypathology and Advanced Age Unit for two years in order to identify the variables that best define the mortality prognosis at medium-term (1–2years) for... more

Chronic obstructive pulmonary disease is associated with increased recurrent peptic ulcer bleeding risk

7 October 2016
Author(s): Kuang-Wei Huang, Yi-Chun Kuan, Nai-Fang Chi, Yao-Hsien Huang, Jiing-Chyuan Luo, Li-Nien Chien

The association between chronic obstructive pulmonary disease (COPD) and the risk of recurrent peptic ulcer bleeding (PUB) remains unclear. In this study, we compared the risk of recurrent PUB... more

Comprehensive evaluation of cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA) with cardiac magnetic resonance

7 October 2016
Author(s): Alberto Francesco Cereda, Patrizia Pedrotti, Lucio De Capitani, Cristina Giannattasio, Alberto Roghi

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic necrotizing vasculitis characterized by hypereosinophilia. EGPA typically develops in three clinical phases, beginning with asthma,... more

Impaired flow-mediated dilation in hospitalized patients with community-acquired pneumonia

7 October 2016
Author(s): Lorenzo Loffredo, Roberto Cangemi, Ludovica Perri, Elisa Catasca, Camilla Calvieri, Roberto Carnevale, Cristina Nocella, Francesco Equitani, Domenico Ferro, Francesco Violi, the SIXTUS study group, SIXTUS (thromboSIs-related eXTra-pulmonary oUtcomeS in pneumonia) study group, Simona Battaglia, Giuliano Bertazzoni, Elisa Biliotti, Tommaso Bucci, Cinzia Myriam Calabrese, Marco Casciaro, Andrea Celestini, Maurizio De Angelis, Paolo De Marzio, Rozenn Esvan, Marco Falcone, Lucia Fazi, Lucia Fontanelli Sulekova, Cristiana Franchi, Laura Giordo, Stefania Grieco, Elisa Manzini, Paolo Marinelli, Michela Mordenti, Sergio Morelli, Paolo Palange, Daniele Pastori, Pasquale Pignatelli, Marco Rivano Capparuccia, Giulio Francesco Romiti, Elisabetta Rossi, Eleonora Ruscio, Alessandro Russo, Maria Gabriella Scarpellini, Luisa Solimando, Gloria Taliani, Stefano Trapè, Filippo Toriello

Community-acquired pneumonia (CAP) is complicated by cardiovascular events as myocardial infarction and stroke but the underlying mechanism is still unclear. We hypothesized that endothelial... more

Simultaneous control of glycemic, blood pressure, and lipid significantly reduce the risk of renal progression in diabetes patients

2 October 2016
Author(s): Po-Ya Chang, Li-Nien Chien, Yuh-Feng Lin, Wen-Ta Chiu, Hung-Yi Chiou

Hyperglycemic, hypertension, and lipid abnormalities are risk factors for diabetic kidney disease However, no study has discussed the association of the simultaneous control of glycemic, blood... more

CHA2DS2-VASc score and clinical outcomes of patients with acute coronary syndrome

1 October 2016
Author(s): Zach Rozenbaum, Avishay Elis, Mony Shuvy, Dina Vorobeichik, Nir Shlomo, Meital Shlezinger, Ilan Goldenberg, Oded kimhi, David Pereg

The CHA2DS2-VASc score has been recommended for the assessment of thromboembolic risk in patients with atrial fibrillation.

Review Article

The appropriate use of proton pump inhibitors (PPIs): Need for a reappraisal

23 October 2016
Author(s): Vincenzo Savarino, Pietro Dulbecco, Nicola de Bortoli, Andrea Ottonello, Edoardo Savarino

The advent of powerful acid-suppressive drugs, such as proton pump inhibitors (PPIs), has revolutionized the management of acid-related diseases and has minimized the role of surgery. The major and... more

Shared decision making and the internist

3 October 2016
Author(s): Victor M. Montori, Marleen Kunneman, Ian Hargraves, Juan Pablo Brito

In this narrative review, we locate within the tradition of great diagnosticians in internal medicine, a fundamental development in patient-centered care: shared decision making (SDM). In this way,... more


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