Published: 29 October 2016
Author(s): Luca Pasina, Laura Cortesi, Mauro Tettamanti, Alessandro Nobili, Pier Mannuccio Mannucci, REPOSI Investigators
Issue: October 2016
Section: Letter to the Editor

Pain in the elderly is associated with substantial disability stemming from reduced mobility, avoidance of activity, falls, depression, anxiety, sleep impairment and isolation [1–3]. Pharmacological management of pain in older adults embrace different types of drugs with different mechanisms of action, but the choice of the more appropriate treatment can be complex, because it is complicated by age-related physiologic changes, polypharmacy and multimorbidity [4]. Paracetamol (acetaminophen) should be the preferred treatment for older patients with mild or moderate pain in light of its favorable safety profile, although it has been found to be modestly effective in reducing pain and failed to improve physical function or stiffness when compared with placebo.

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