Published: 7 May 2021
Author(s): Peter Wohlfahrt, Dominik Jenča, Vojtěch Melenovský, Janka Franeková, Antonín Jabor, Marek Šramko, Vladimír Staněk, Michael Želízko, Rudolf Poledne, Jan Piťha, Věra Adámková, Josef Kautzner

Lipoprotein(a) (Lp[a]) consists of a lipoprotein moiety identical to low density lipoprotein (LDL) cholesterol, as well as a plasminogen-similar glycoprotein apo(a). About 90% of a person's Lp(a) level is genetically determined. In the primary prevention setting, both epidemiological data and genetic studies proved the association of elevated Lp(a) with increased risk of cardiovascular disease and aortic stenosis [1–3]. Both European [4] and American [5] guidelines recommend Lp(a) measurement at least once in each adult person's lifetime, especially in patients with family history of premature atherosclerotic cardiovascular disease (CVD) or in patients with personal history of atherosclerotic CVD not explained by major risk factors.


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