“Obesity and ageing: two side of the same coin” in 2020 Tam et al. have summarised the complex pathophysiological interaction and mutual relationship between obesity and ageing in a comprehensive paper characterized by this iconic title [1]. As a matter of fact, the progressive loss of health and physical function inexorably linked to ageing is enhanced by obesity and excess calorie intake with similar mechanisms such as impaired autophagy, mitochondrial dysfunction, enhanced apoptosis and inflammation.
