Albumin, the most abundant circulating protein in blood (accounting for 50% of the plasma proteins), composed of 585 amino acids with a molecular weight of 66 kDa, binds and transports various drugs and substances in plasma, and most importantly, it maintains the oncotic (colloid-osmotic) pressure of blood and influences the physiological function of the circulatory system (Fig. 1) [1–4]. It opposes the effect of hydrostatic blood pressure, which, if unopposed, would push water and small molecules out of circulation into the interstitial space and produce edema.
