We read with great interest the article by Eiferman et al., entitled “Isolated joint involvement in Whipple’s disease: a cohort study”, recently published in the European Journal of Internal Medicine [1]. In 60 patients with Whipple’s disease (WD) and joint involvement, the authors classified cases according to the presence of specific gastrointestinal, cardiac, or neurological manifestations into clinically isolated joint involvement (CIJI) and systemic joint involvement (SJI), and demonstrated a rapid articular response to doxycycline plus hydroxychloroquine in real-world practice.
