I read with great interest the study by Sogbe et al. entitled “Inflammatory spectrum of frailty: Association between the systemic immune-inflammation index and frailty in liver transplant candidates", which examines the relationship between the systemic immune-inflammation index (SII) and frailty in patients with advanced chronic liver disease (AdvCLD) [1]. The authors should be commended for drawing attention to an important clinical issue. Frailty has become increasingly recognized as a critical determinant of adverse outcomes in patients with cirrhosis, including poorer post-transplant outcomes, increased mortality, and hospitalizations [2,3].
