August 2018
22 ArticlesNo Section
Validation of the simplified Animal Naming Test as primary screening tool for the diagnosis of covert hepatic encephalopathy
Diagnosis of covert hepatic encephalopathy (CHE) is time consuming in clinical practice. Recently, a new diagnostic tool - the simplified Animal Naming Test (S-ANT1) - was presented with promising... more
Relationship between pneumonia and cardiovascular diseases: A retrospective cohort study of the general population
To evaluate the relationship between cardiovascular diseases (CVDs) and pneumonia in the general population.
Mortality after pulmonary embolism in patients with diabetes. Findings from the RIETE registry
Among patients presenting with pulmonary embolism (PE), those with diabetes are at increased risk to die than those without diabetes. The reasons have not been identified. We used the RIETE (Registro... more
Association between ankylosing spondylitis and chronic obstructive pulmonary disease in Taiwan
One cross-sectional study conducted by Sharif et al. reported that patients with ankylosing spondylitis had a higher proportion of chronic obstructive pulmonary disease than controls (46% versus 18... more
Letter to the Editor
Torsemide versus furosemide in heart failure patients: A meta-analysis of randomized controlled trials
In 2012, total cost for heart failure (HF) was $30.7 billion and by 2030, it is projected to increase to $69.7 billion [1]. Hospitalizations for HF are a major reason for increased cost burden [2].... more
Prevalence of thrombocytopenia and thrombocytosis upon acute hospital admission to internal medicine units. A cross-sectional study in Denmark
Platelets are involved in primary hemostasis by initiating clot formation. However, they have pleiotropic effects [1]. Due to these multiple effects and the frequency of stress and inflammation in... more
Implications for screening in the hypothyroid presentation of autoimmune polyglandular syndrome
The “hypothyroid” presentation of the recently reported case of autoimmune polyglandular syndrome [1] generates unique insights into the potential role of screening for related autoimmune disorders... more
Transcatheter patent foramen ovale closure versus standard medical therapy for prevention of recurrent stroke: Updated Meta-analysis with an importance on shunt size
Presence of patent foramen ovale (PFO) has been associated with increased risk of cryptogenic stroke [1]. PFO is present in about 25% of the general adult population but is found in upto 40% of... more
Can semen protect human from ZIKV infection?
Zika virus (ZIKV) has always been concerned by public health, especially among pregnant women. Because Zika virus was confirmed to transmit to human through sexual intercourse, which could cause... more
Utility of dynamic contrast-enhanced MRI to assess small bowel perfusion in paroxysmal nocturnal hemoglobinuria before and after eculizumab
Thrombosis is the leading cause of morbidity and mortality in paroxysmal nocturnal hemoglobinuria (PNH), accounting for 40–67% of deaths and is frequently observed in atypical sites, such as... more
Lymphocytic variant hypereosinophilia: a challenging diagnosis of a rare disease with pleomorphic clinical picture
Hypereosinophilia, defined by a peripheral eosinophil count >1500/mmc or tissue eosinophilia, is associated with numerous clonal hematologic and non-hematologic disorders and reactive conditions [... more
Minor salivary gland biopsy is more effective than normal appearing skin biopsy for amyloid detection in systemic amyloidosis: A prospective monocentric study
The term “amyloidosis” encompasses a large group of diseases characterized by extracellular deposition of fibrillar proteins impairing organ function. Classification of amyloidosis relies on the... more
Are journals following the ICMJE recommendations complying with conflicts of interest disclosure policies
The International Committee of Medical Journal Editors Recommendations (ICMJE-R) asks journals to develop policies regarding the disclosure of conflicts of interest (CoI) for authors, reviewers and... more
Anti-PD1 therapy-associated cutaneous leucocytoclastic vasculitis: A case series
Immune-checkpoint inhibitors (ICIs) have shown remarkable efficacy in multiple cancer types [1]. However, these therapies may lead to immune-related adverse events (irAEs) as they promote immune... more
Original Article
Associations of proton pump inhibitors and hospitalization due to hyponatremia: A population–based case–control study
Small observational studies and case reports have indicated that proton pump inhibitors (PPIs) may cause hyponatremia. Whether there is a difference between the individual PPIs is yet unknown. Since... more
Trends in management and outcome of patients with non-ST elevation acute coronary syndromes and peripheral arterial disease
Patients with non ST-segment elevation acute coronary syndromes (NSTE-ACS) and peripheral arterial disease (PAD) present a worse prognosis compared to those without PAD. We sought to describe... more
Type 2 diabetes increases the risk of hospital admission for heart failure and reduces the risk of in hospital mortality in Spain (2001–2015)
To compare trends in incidence, clinical characteristics and outcomes of heart failure (HF) hospitalizations among patients with or without type 2 diabetes (T2DM) in Spain (2001–2015).
Integrated primary and geriatric care for frail older adults in the community: Implementation of a complex intervention into real life
Frailty is highly prevalent in older persons and associated with negative health-related events and costs. Despite successful clinical trials, translation of evidence into implementation of dedicated... more
Mortality and morbidity for cardiopulmonary diseases attributed to PM2.5 exposure in the metropolis of Rome, Italy
The aim of the study was to evaluate the health effects associated with the exposure to ground-level of particulate matters with aerodynamic diameter ≤ 2.5 μm (PM2.5) on citizens in Rome (Italy) in... more
National trends in diabetes mellitus hospitalization in Spain 1997–2010: Analysis of over 5.4 millions of admissions
To analyze national trends in the rates of hospitalizations (all-cause and by principal discharge diagnosis) in total diabetic population of Spain.
Hyponatraemia during an emergency medical admission as a marker of illness severity & case complexity
Altered sodium balance at time of an emergency medical admission adversely impacts on outcome; whether hyponatraemia is independently associated with outcomes or a surrogate of acute illness severity... more
Review Article
The role of nutrition in ageing: A narrative review from the perspective of the European joint action on frailty – ADVANTAGE JA
There is sufficient evidence that nutrition and frailty status are related. In order to deliver quality management of frail and pre-frail patients, clinicians and dieticians should understand the... more