Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease with variable manifestations across Mediterranean regions. This study compares FMF cohorts from Italy (Apulia) and Lebanon. We analyzed a cohort of 443 FMF patients, 165 Italians (females: males = 90:75) and 278 Lebanese (females: males = 173:105). Clinical records/interviews provided data on demographics, MEFV genetic testing, and treatments. A 55-item questionnaire in 54 Italians and 42 Lebanese patients assessed disease knowledge, management, misdiagnoses, attack frequency (yearly), duration (days), body temperature, symptoms prevalence and frequency, and severity score before/after treatment.
