February 2026
40 ArticlesNo Section
Critical considerations on uric acid in HFmrEF: from biomarker to metabolic integrator. Author's reply
Dear Editor,
Corrigendum to “Natural history of the severe subtype of MYH9-related disease (Epstein syndrome)” [European Journal of Internal Medicine 138 (2025) 6354]
The authors regret that an error appeared in Fig. 1 of the published article. The panels for Deafness, Renal failure, and Proteinuria inadvertently displayed the Kaplan-Meier curves for the R702C/H... more
Clinical Insights
Advances in syncope: Recent evidence and clinical implications
The purpose of this article is the synthesis of the most relevant advances in syncope research over the last decade, bridging current practice with future directions across settings of care (... more
Commentary
To dilate or not to dilate: the puzzle of phenotyping heart failure with mildly reduced ejection fraction
Heart failure (HF) is a significant global health concern burdened by an increasingly prevalent issue in both developed and developing countries [1]. It currently affects over 20 million people... more
Intensification of monitoring for improving detection of atrial fibrillation after a presumed “trigger- induced episode” due to potentially reversible factors: what tools and what implications for decision making?
Atrial fibrillation (AF) is an arrhythmia with an increasing epidemiological burden worldwide[1] even if its precise prevalence cannot be defined, since it is frequently asymptomatic, either in... more
Why we measure frailty: Aligning tools with use
Frailty has become an increasingly prominent topic of investigation, attracting substantial and growing attention within the scientific community. However, such rapid expansion of interest also... more
A call to action: Bridging glucose monitoring and treatment gaps in inpatient diabetes care
Diabetes mellitus remains a major global health challenge, increasing clinical, social, and economic burdens on individuals and healthcare systems. In nearly every region of the world, the rising... more
Internal Medicine Flashcard
Perisplenic fibrosis
Case 1: A 35-year-old woman presented with diabetes insipidus diagnosed at the age of six years. Ten years after diagnosis, she presented with facial sinus infiltration, pleural thickening, long bone... more
A 74-year-old man with skin thickening and ulcers
A 74-year-old man with hypertension, type 2 diabetes (HbA1c 12 %), and chronic kidney disease (KDIGO IIb) presented to the dermatology emergency department with an eight-month history of progressive... more
Letter to the Editor
Bronchoscopy, ventilator dose and outcomes in severe CAP: Reading the sex signal. Author's reply
Dear Editor
Bridging the gap: Phenotype-specific considerations for rituximab therapy in IgG4-related disease. Author's reply
We thank Li and Wang for their thoughtful appraisal of our study and for emphasizing the growing need for phenotype-individualized approaches in IgG4-related disease (IgG4-RD) [1,2]. Their comments... more
The widening gap between point-of-care ultrasonography course participation and supervision resources
Dear Editor,
Critical considerations on uric acid in HFmrEF: from biomarker to metabolic integrator
To the editor,
West Nile virus infection: New guitars in town for the internal medicine community
Dear Editor,
Methodological considerations for interpreting the association between central systolic blood pressure and brain health. Author’s reply
Dear Editor,
Antibiotic use in hospitalized older adults according to WHO AWaRe classification: data from the REPOSI register
Antimicrobial resistance is a growing global concern and represents a major threat to public health [1]. In response, many countries have implemented guidelines aimed at promoting the rational use of... more
Bronchoscopy, ventilator dose and outcomes in severe CAP: reading the sex signal
We read with great interest the analysis conducted by Garin et al. regarding sex-related differences in adults intubated for severe community-acquired pneumonia within the EU VAP CAP platform, which... more
Cognitive impairment in familiar hypercholesterolemia: How much is vascular and how much is confounding? Author's reply
We sincerely thank Messina et al. for their thoughtful and valuable comments regarding our study. We fully acknowledge the importance of the points raised and appreciate their contribution to the... more
Bridging the gap: Phenotype-specific considerations for rituximab therapy in IgG4-related disease
We were pleased to read the recent article by Goni et al., entitled “Effectiveness and safety of rituximab across the four phenotypes of IgG4-related disease: a European multi-center cohort study of... more
Heart failure with preserved ejection fraction in older inpatients: Where diagnostic algorithms meet geriatric reality
Heart failure with preserved ejection fraction (HFpEF) represents a growing and increasingly prevalent phenotype of heart failure (HF) in older adults, yet its recognition in routine clinical... more
Cognitive impairment and vascular injury in familial hypercholesterolemia: Looking beyond the association
We read with great interest the article by Sabrina Scilletta et al. published in the European Journal of Internal Medicine, which explored the relationship between cognitive function and subclinical... more
Methodological considerations for interpreting the association between central systolic blood pressure and brain health
We read with great interest the recent article by Yu et al. (2025) [1] in the European Journal of Internal Medicine, which investigated the association between central systolic blood pressure (cSBP... more
Utility of following morning body weight in patients with hyponatremia due to chronic SIAD
In patients with chronic hyponatremia, SNa must be maintained above 134 mEq/l to minimize associated morbidity [1].
Tezepelumab in severe asthma: Strengthening real-world evidence and addressing unresolved clinical questions
We were pleased to read the recent article by Poto et al. entitled “Effectiveness of tezepelumab in severe asthma: A multicenter real-world study,” published in the European Journal of Internal... more
Meta-analysis of the relationship between internal microplastic and health outcomes
Dear editor,
Cognitive impairment in familiar hypercholesterolemia: how much is vascular and how much is confounding?
Dear editor,
Understanding the threat of West Nile virus infection. Comment on prevention and therapy
We read with interest the article from Gallo et al., which provides a clear and structured overview of the West Nile virus (WNV), particularly valuable for clinicians unfamiliar with its clinical... more
Original Article
Effects of calcium channel blockers on GDMT prescription and outcomes according to ejection fraction: IN-HF real world data
Dihydropyridine calcium channel blockers (DHP-CCB) are widely used in heart failure (HF), despite the lack of data regarding their safety, especially in patients with reduced ejection fraction (HFrEF... more
Gaps in Glycaemic Monitoring and Underuse of Cardioprotective Glucose-lowering Agents: Challenges of inpatient diabetes care identified by EFIM’s Diabesity Day Survey 2024
People with diabetes and people with obesity have an increased risk of hospitalisation, tend to have longer hospital stays, and have higher mortality when hospitalised (1–3). Diabetes management... more
Both underweight and obese patients are prone to relapse after ablation of paroxysmal atrial fibrillation
Being overweight has been associated with arrhythmia recurrence after atrial fibrillation (AF) ablation, but the optimal threshold to identify high risk patients has not been well established.... more
Monitoring time-to-detection of recurrent atrial fibrillation in patients with transient new-onset atrial fibrillation detected initially during hospitalization for noncardiac surgery or medical illness
Approximately one-third-of patients with transient new-onset atrial fibrillation (AF) during hospitalization for noncardiac surgery or medical illness will have recurrent AF within 1 year when... more
Endothelin-1 as dual marker for renal function decline and associated cardiovascular complications in patients with chronic kidney disease
Cardiovascular (CV) complications are the leading cause of death in patients with chronic kidney disease (CKD). Endothelin-1 (ET-1), a potent vasoconstrictor involved in both renal and vascular... more
Prognostic role of TAPSE/PASP ratio among older patients with acute heart failure and preserved ejection fraction
Right ventricular (RV)-pulmonary circulation (PC) uncoupling is associated with poor outcome in patients with Heart Failure with Preserved Ejection Fraction (HFpEF). Tricuspid annular plane systolic... more
Prognostic impact of left ventricular dilatation in heart failure with mildly reduced ejection fraction
This study investigated the prognostic value of left ventricular (LV) dilatation in patients with heart failure with mildly reduced ejection fraction (HFmrEF).
Sex differences in venous thromboembolism outcomes: findings from the GARFIELD-VTE registry
Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is a major cause of morbidity and mortality [1] VTE is linked to several risk factors, including age,... more
An exploratory model for short-term risk stratification in intermediate-high-risk pulmonary embolism running head: The STAMP score
Patients with acute pulmonary embolism (PE) characterized by hemodynamic stability, evidence of right ventricular (RV) dysfunction (RVD), positive cardiac biomarkers and high simplified pulmonary... more
Review Article
Frailty measurement in research and clinical practice: An updated review
Frailty is a highly prevalent geriatric condition, affecting between 12–24% of older adults globally. It remains a major cause of morbidity and mortality in older adults. Incorporating frailty... more
Drug-induced rise in serum creatinine: cystatin C to the rescue? Evidence, pitfalls and knowledge gaps
Serum creatinine (SCr) concentration is a cheap biomarker of kidney function measured globally millions of times every day. It is part of the KDIGO definitions of both chronic kidney disease and... more
Multidisciplinary strategies and new technologies in the management of sarcoidosis
Sarcoidosis exemplifies the complexity of modern internal medicine, requiring comprehensive, system-based management. The disease is characterized by non-caseating granulomas and can affect virtually... more
Multimodality imaging for cardiac amyloidosis: clinical applications and future directions
Systemic amyloidosis are a group of disorders characterized by the extracellular deposition of misfolded protein fibrils [1]. When the heart is involved, the condition is referred to as cardiac... more