Peripheral ulcerative keratitis (PUK) is a rare and severe ocular manifestation frequently associated with systemic autoimmune diseases. This retrospective two-center observational study including patients with PUK and a systemic autoimmune disease at two tertiary referral centres aimed to characterize clinical and histopathologic features, treatment strategies, relapses, and ocular outcomes of autoimmune-associated PUK, and to analyse its relationship with systemic disease activity. A total of 24 patients (35 eyes) were identified, 62.5 % female, with a median age of 58.5 years and a mean follow-up of 14.4 years.
