July 2024

130 Articles

Clinical Insights

Recommendations for an Interdisciplinary Patient Review for patients with multiple long-term conditions in the hospital

29 June 2024
Author(s): E.A. Gans, U.W. de Ruijter, J.F. de Groot, F. van den Bos, B.C. van Munster

An estimated 32 % of the European population live with multiple long-term conditions (MLTC), defined as two or more chronic conditions [1]. Patients with MLTC require integrated, tailored care, which... more

Sepsis scoring systems: Mindful use in clinical practice

22 May 2024
Author(s): Luigi Mario Castello, Francesco Gavelli

Sepsis is a challenging condition: the high prevalence and the complexity of its clinical presentation lead to high morbidity and mortality. The most updated definition of sepsis and septic shock,... more

Towards precision medicine in COPD: Targeting type 2 cytokines and alarmins

17 May 2024
Author(s): Gilda Varricchi, Remo Poto

Chronic obstructive pulmonary disease (COPD) is a main global epidemic increasing as population age and affecting approximately 10% of subjects over 45 years. COPD is a heterogeneous inflammatory... more


Blood pressure control in the hypertensive population. Factors involved and perspectives

2 July 2024
Author(s): Giuseppe Mancia, Federico Rea, Giovanni Corrao

This issue of the European Journal of Internal Medicine includes a paper by Coca and collaborators [1] which focuses on a problem of crucial importance for public health. That is, the persistent... more

Statins to prevent anthracycline-related myocardial toxicity: The jury is still out

8 June 2024
Author(s): Mario Mandalà, Claudia Bartolini, Cecilia Becattini

Anthracyclines are cytostatic antibiotics [1] that have been used since the 1970s. These anticancer agents still represent the backbone of many chemotherapy-based strategies with a curative intent in... more

Use simple tools to improve complex conditions

17 May 2024
Author(s): Michele Vitacca, Mara Paneroni

"Medicine is both an art and a science; the art of listening, the art of understanding, and the art of predicting." (Hippocrates)

Low-dose colchicine for chronic stable atherosclerosis: Under-appreciated and under-prescribed

17 May 2024
Author(s): Paul M Ridker

In June of 2023, the United States Food and Drug Administration (FDA) approved the use of low dose colchicine as the first anti-inflammatory drug to treat atherosclerotic disease. Specifically, “... more

Artificial intelligence supported ultrasonography: Can it be the solution for early and accurate diagnosis of steatotic liver disease?

24 April 2024
Author(s): Stella Gabeta, Eirini I. Rigopoulou, George N. Dalekos

Last December, a multi-society Delphi consensus reported on the new nomenclature and definitions of fatty liver disease [1]. Accordingly, the previous terms of non-alcoholic fatty liver disease (... more


Corrigendum to “Systemic diseases associated with a diagnosis of achalasia: A case-control study with the All of Us research program” [European Journal of Internal Medicine 104C (2022) 125–127]

24 May 2024
Author(s): Erik Almazan, Gayane Yenokyan, Kenneth Ng

The authors regret that one of the tables in the above published article. The correct version of the table is below:

Internal Medicine Flashcard

Acrocyanosis and edema in a male with thrombocytosis, polyneuropathy and monoclonal gammopathy

12 June 2024
Author(s): Íñigo Gredilla Zubiría, Lucía Álvarez Freire, Héctor Meijide Míguez

A 77-year-old male consulted for edema, skin changes, asthenia, anorexia, weight loss and leg corkiness of more than one year of evolution. About two years earlier, primary hypothyroidism was... more

Black fingernails

21 May 2024
Author(s): Xin Nie, Xue Sun, Lin Li

A 60-year-old man presented with a 2-weeks history of darkening and tenderness of fingernails. He was diagnosed with local advanced squamous cell lung cancer and initiated neoadjuvant chemotherapy (... more

Patchy reversible renal vasoconstriction

20 May 2024
Author(s): Haruka Maruyama, Ken-ei Sada, Takayasu Ohtake

A 24-year-old male patient presented to the emergency department with left-sided back pain and bilateral lower limb myalgia. The previous day, he was involved in a head-on motor-vehicle collision at... more

A man with fever, headache, and ulcers

20 May 2024
Author(s): Giuseppe Famularo, Alessandro Stasolla, Massimo Bracci

A 25-year-old male attended our department because of a 2-week history of malaise, severe headache, myalgia, and low-grade to spiking fevers. He had no medical history, was not taking any medications... more

Surfers' myelopathy

20 May 2024
Author(s): Kento Arai, Kosuke Ishizuka, Mori Nakai

A 29-year-old Japanese man presented with bilateral weakness in the legs and low back pain. On the day of admission, the patient had gone surfing for the first time in his life and developed sudden... more

Internal Medicine Flashcards

An unexpected detour: Acute throat pain and trismus in a fast-food deliveryman

11 April 2024
Author(s): Hidenori Takahashi, Marino Fujisaki, Yuko Hata

A 40-year-old man fast-food deliveryman presented to the emergency department with a severe sore throat and trismus. His-symptoms rapidly escalated over 24 h, impairing his ability to speak, eat, and... more

Invited Review Article

Pharmacotherapy for older people with obesity

18 June 2024
Author(s): Luke D. Boyle, Feray Akbas, Dilek Yazıcı, Barbara M. McGowan, Volkan Yumuk

The prevalence of obesity continues to rise in Europe, particularly in adults aged between 60 and 74 years [1]. Despite this rising prevalence of obesity in older adults, use of medication for weight... more

Letter to the Editor

Sudden death in congenitally corrected transposition of the great vessels

19 July 2024
Author(s): Antonis A. Manolis, Theodora A. Manolis, Antonis S. Manolis

Transposition of the great arteries (TGA) comprises dextro-TGA and levo-TGA (L-TGA). In dextro-TGA, the aorta, arising from the right ventricle (RV), is positioned to the right of the pulmonary... more

How do we diagnose Miyoshi Muscular Dystrophy in the absence of symptoms?

17 July 2024
Author(s): Özge Sönmez, Uğur Kimyon, Mehmet Çopur, İbrahim Ataş, Işıl Bavunoğlu

Elevated liver enzyme is a common incidental laboratory finding. Evaluating such problems particularly in asymptomatic patients might be challenging. Alterations in liver enzymes are not enterily... more

Impact of an active case-finding strategy in autoimmune gastritis

16 July 2024
Author(s): Marco Vincenzo Lenti, Emanuela Miceli, Shamim Joudaki, Antonella Gentile, Antonio Di Sabatino, Autoimmune Gastritis Team

Dear Editor,

Evaluating cognitive impairment in emergency department: Challenges with screening tools. Authors’ reply

16 July 2024
Author(s): Tanguy Espejo, Leon Chrobok, Christian H. Nickel, Roland Bingisser

We appreciate the thoughtful feedback provided by Khenhrani et al. [1] regarding our article "Prognostic value of cognitive impairment, assessed by the Clock Drawing Test, in emergency department... more

Sodium–Glucose Co-transporter 2 Inhibitors treatment improve pancreatic β-cells function and insulin resistance in patients with Type 2 diabetes

12 July 2024
Author(s): Fang-Hong Shi, Li Xu, Long Shen, Min-Jia Cao, Hao Li

Diabetes is a leading cause of death and disability [1]. Approximately, more than 1.31 billion people will have diabetes by 2050 [1,2]. Insulin resistance in target tissues and insufficient insulin... more

Pioneering the future: CRISPR-Cas9 gene therapy for hereditary hemorrhagic telangiectasia. Author's reply

10 July 2024
Author(s): Pau Cerdà, Cinthia Aguilera, Antoni Riera-Mestre

We read the recent innovative Letter by James and Sehgal, commenting on our article published in the European Journal of Internal Medicine and advocating for the development of a CRISPR-Cas9 gene... more

Insights into recurrence of hypertriglyceridemia-associated acute pancreatitis: Methodological challenges

9 July 2024
Author(s): Sehrish Gaho, Raja Ram Khenhrani, Amna Afaque

We read the article by Ling Ding et al. with great interest [1]. We would like to commend the authors for their comprehensive study, which found that hypertriglyceridemia-associated acute... more

Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors combination therapy versus monotherapy and major adverse cardiovascular events: Do the benefits add up?

8 July 2024
Author(s): Paschalis Karakasis, Dimitrios Patoulias, Nikolaos Fragakis, María Rosa Bernal-López, Ricardo Gómez-Huelgas

Dear Editor,

Autonomic dysfunction in post-acute sequelae of COVID-19

8 July 2024
Author(s): Marie-Claire Seeley, Howard O'Brien, Celine Gallagher, Caelum Schild, Dennis H. Lau

The novel coronavirus disease (COVID-19) pandemic has resulted in over 750 million confirmed cases since its emergence. There has been growing attention towards long-COVID or post-acute sequelae of... more

Predictive performance of HAS-BLED, ORBIT, ABC, and DOAC scores for major bleeding in atrial fibrillation patients on DOACs

4 July 2024
Author(s): Shan Zeng, Wengen Zhu, Siyu Guo, Hong Hong

Atrial fibrillation (AF) is the most common type of irregular heartbeat in clinical practice. It has been found to increase the risk of ischemic stroke by 5 times. To mitigate this risk, oral... more

Pitfalls in the detection of anti-Nucleolar Organizer Region 90 (NOR90) antibodies

22 June 2024
Author(s): Satoshi Kamiya, Yoshinao Muro, Yuta Yamashita, Mariko Ogawa-Momohara, Masashi Akiyama

Dear Editor,

Risk of psoriatic arthritis development with interleukin-17 inhibitors compared to tumour necrosis factor inhibitors

22 June 2024
Author(s): Po-Cheng Shih, An-Ping Huo, Pui-Ying Leong, James Cheng Chung Wei

Psoriatic arthritis (PsA) is one of the most important comorbidities in patients with psoriasis (PsO), with approximately one third of PsO patients developing arthritis over their whole lifetime [1... more

Direct oral anticoagulants or vitamin K antagonists in adult patients with congenital heart disease?

21 June 2024
Author(s): Paschalis Karakasis, George Giannakoulas, Panagiotis Theofilis, Dimitrios Patoulias, Nikolaos Fragakis

Dear Editor,

Divergent views on prescription adherence: A qualitative comparison of perspectives from the patient, pharmacist, and physician triad

20 June 2024
Author(s): Anjali Bundele, Hui Wen Lim, Amartya Mukhopadhyay, Phillip H. Phan, Jennifer Sumner

Up to 70 % of patients fail to follow prescribed regimens [1], resulting in detrimental health and economic consequences. While existing adherence research often focuses on either the traditional... more

Myocardial infarction in foreign-born individuals in the total population of Sweden

17 June 2024
Author(s): Per Wändell, Xinjun Li, Axel C Carlsson, Jan Sundquist, Kristina Sundquist

Cardiovascular diseases (CVD) are still frequent globally with a high mortality rate, even if the incidence has decreased since the 1980s in Europe, especially in Northern Europe [1], including a... more

Beneficial effects of early low-dose methylprednisolone with long-term treatment in ARDS

15 June 2024
Author(s): Haiming Hu, Shuting Wei, Jiayin Huang, Lokesh Sharma, De Chang

Since the concept of acute respiratory distress syndrome (ARDS) was first proposed by Ashbaugh in 1967 [1], it has been refined several times for better reflect the phenotype in recent decades. The... more

Pioneering the future: CRISPR-Cas9 gene therapy for hereditary hemorrhagic telangiectasia

14 June 2024
Author(s): Michael James, Viren S. Sehgal

We read with great interest the article titled “New genetic drivers in hemorrhagic hereditary telangiectasia’, recently published in the European Journal of Internal Medicine. Cerdà and colleagues... more

The role of age in recognizing cognitive impairment in the emergency department

11 June 2024
Author(s): Ozlem Yilmaz

I read with interest the study by Espejo et al. published in the European Journal of Internal Medicine. In this study, patients presenting to the emergency department with vague symptoms who met the... more

Cardiovascular outcome with SGLT2i and GLP1RA

7 June 2024
Author(s): Soo Lim, Minji Sohn, Michael A. Nauck

Dear editor,

Clostridioides difficile infection as a potential trigger for Familial Mediterranean Fever attacks and fecal transplantation as a rescue

7 June 2024
Author(s): Sophie Georgin-Lavialle, Marion Delplanque, Claude Bachmeyer, Léa Savey, Harry Sokol, FMF Clostridium Study Group


Evaluating cognitive impairment in emergency department: Challenges with screening tools

5 June 2024
Author(s): Raja Ram Khenhrani, Sapna Devi

We read the article by Tanguy Espejo et al. with great interest [1]. The authors have performed admirably in achieving the purpose of the research. The article concludes that Clock Drawing Test (CDT... more

Definition of an algorithm to identify patients with sickle-cell disease in the French National Health Database

31 May 2024
Author(s): Ondine Walter, Pierre Cougoul, Yoann Zadro, Guillaume Moulis, Margaux Lafaurie

Sickle cell disease (SCD) is the most frequent inherited disease with monogenic transmission (300,000 newborns per year in the world) [1]. SCD is due to a mutation on both alleles of the gene coding... more

Navigating the challenges: Would onboarding bootcamps enhance comfort and wellbeing of residents in medicine?

28 May 2024
Author(s): Jonathan Assouly, Margaret Hayes, Blaise Debien, Camille Roubille, Boris Jung

Medical interns (first-year residents) and residents (second-to fourth-year residents) in France are junior medical staff in charge of overseeing up to 200 medicine beds during night shifts, with no... more

Dual tobacco smoking, electronic cigarette use and COVID-19 outcomes

27 May 2024
Author(s): Tahlia Grammatopoulos, Ellana Yeoh, Nouhad El-Haddad, Kristin Carson-Chahhoud, Freddy Sitas

We congratulate Scala and colleagues on the publication of their paper on electronic cigarette (e-cigarette) use and Coronavirus Disease 2019 (COVID-19) outcomes [1]. Scala et al. focused on e-... more

Survival analysis of diabetes cardiovascular outcome trials using reconstructed Kaplan-Meier curves

25 May 2024
Author(s): Marko Skelin, Bruna Perkov-Stipičin, Marko Lucijanić, Eugen Javor, Ivan Krečak

The management of type 2 diabetes mellitus (T2DM) has witnessed a treatment paradigm in the light of recent cardiovascular outcomes trials (CVOTs) which have placed more emphasis on cardiovascular... more

Multi-organ abnormalities assessed by a single MRI scan in individuals with blood cancer

24 May 2024
Author(s): Sophie Reed, Michele Pansini, Charlie Diamond, Amitava Banerjee, Helena Thomaides Brears, Onima Chowdhury

During the COVID-19 pandemic individuals with all blood cancers were classified as clinically vulnerable and at high risk of complications and death. Our study sought to determine if individuals with... more

The association between long-acting muscarinic antagonist-based therapy and the risk of urinary tract infection in patients with chronic obstructive pulmonary disease

24 May 2024
Author(s): Ping Li, Jianjun Luo, Jun Chen, Yongchun Shen, Fuqiang Wen

Chronic obstructive pulmonary disease (COPD) is a common respiratory disease featuring persistent respiratory symptoms and progressive airflow limitation. Long-acting muscarinic antagonists (LAMAs)... more

Comparison of factor X inhibitors versus vitamin K antagonists in atrial fibrillation patients on dialysis

19 May 2024
Author(s): Xi Chen, Wengen Zhu, Meiming Lin

Atrial fibrillation (AF) is a common heart rhythm disorder that occurs in patients with end-stage kidney disease (ESKD). Recent studies have shown that the incidence of AF increases in patients... more

Stenting improves cardiovascular clinical outcomes in patients with middle aortic syndrome caused by aortoarteritis: Long-term results

14 May 2024
Author(s): Qian Wang, Hui Dong, Hong-Wu Li, Yu-Bao Zou, Xiong-Jing Jiang

Takayasu arteritis (TA), also known as aortoarteritis, often involves the middle aorta and manifests as middle aortic syndrome (MAS) [1]. Owing to persistent and severe hypertension attributed to... more

Self-publishing in the history of medicine: The paradoxical case of Edward Jenner's science-changing monograph (1798)

13 May 2024
Author(s): Francesco M. Galassi, Elena Varotto, Domenico Ribatti

According to the Cambridge Dictionary, self-publishing is regarded as the act of arranging or paying for one's ‘own book to be published, rather than having it done by a publisher’ [1]. Whether it be... more

Nitrous oxide toxicity in adult patients with sickle cell disease

13 May 2024
Author(s): Katia Stankovic Stojanovic, Aline Santin, Catherine Veyssier-Belot, Jean-Benoit Arlet, François Lionnet

Sickle cell disease (SCD) is an inherited autosomal recessive disorder that confers atypical haemoglobin called haemoglobin S, which can distort red blood cells in sickle-shaped cells and modifies... more

Kidney function and sarcopenia: A risk assessment. Author's reply

10 May 2024
Author(s): Rafael Moreno-González, Francesc Formiga, Paolo Fabbietti

To the Editor

Environmental costs of noninvasive cardiac testing for acute chest pain after ED discharge

7 May 2024
Author(s): Ludovico Furlan, Aniket A Kawatkar, Benjamin C Sun, Nicola Montano, Giorgio Costantino

Acute chest pain (ACP) accounts for more than 7 million Emergency Department (ED) visits each year in the US [1]. Patient management initially relies on the estimated risk of short term... more

Monkeypox: A risk factor for inflammatory diseases?

3 May 2024
Author(s): Giuseppe Famularo

I read with interest the article by Patauner and colleagues [1]. Even though most cases have a full recovery without significant sequelae, little is known about the mid- and long-term outcome of... more

The new nomenclature SLD and categories provided better classification for elderly Chinese with liver steatosis

3 May 2024
Author(s): Lixia Qiu, Shuang Zhang, Yang Zhang, Calvin Q Pan, Jing Zhang

We were inspired by the recent article by van Erpecum and Dalekos [1], which proposed new horizons in the diagnosis and management of patients with metabolic dysfunction-associated steatotic liver... more

Prevalence and outcome of occult giant cell arteritis

29 April 2024
Author(s): Lien Moreel, Albrecht Betrains, Ellen De Langhe, Daniel Blockmans, Steven Vanderschueren

Giant cell arteritis (GCA) is a large vessel vasculitis that preferentially affects the cranial arteries and the aorta and its proximal branches [1]. Presenting features of GCA may include symptoms... more

Use of direct oral anticoagulants in patients with left ventricular thrombus

27 April 2024
Author(s): Kai Chen, Shenglong Yu, Wengen Zhu, Xin Liu

Left ventricular thrombus (LVT), one of the most feared and common complications of acute myocardial infarction (AMI), still causes morbidity and mortality in a proportion of patients despite the... more

Short-term trends in gastric cancer incidence after insurance coverage expansion for Helicobacter pylori eradication in Japan

22 April 2024
Author(s): Yusaku Kajihara

Helicobacter pylori (H. pylori) infection is a risk factor for gastric cancer (GC). The International Agency for Research on Cancer has recommended population-based screening and eradication of H.... more

Synergistic effect of spironolactone/ARB on cardiovascular endpoints in heart failure patients with preserved ejection

18 April 2024
Author(s): Xiao Liu, Yue Wang, Kaihang Yiu, Yuling Zhang, Jingfeng Wang

Currently, treatment options for HFpEF are limited. Several randomized controlled trials of RAAS inhibitors for HFpEF, including perindopril, candesartan, irbesartan, and spironolactone, have yielded... more

Effect of direct oral anticoagulants in patients with cerebral venous thrombosis

16 April 2024
Author(s): Ailin Li, Wengen Zhu, Xin Liu

Cerebral venous thrombosis (CVT) is a rare clotting disorder that mainly affects younger females. In order to achieve recanalization of cerebral veins and reduce the risk of venous thromboembolism (... more

‘Impact of Haemophilus spp. as a sexually transmitted disease’

15 April 2024
Author(s): Juan Gabriel Sánchez-Cano, Gonzalo Sierra-Torres, Laura Muñoz-Echeverría, Adriana Ortega-Fernández, María Velasco-Arribas

Despite the increasing prevalence of Haemophilus spp. isolates in urethral exudates in our health area, a city with more than 160,000 inhabitants in the south of Madrid, there are still uncertainties... more

The clinical spectrum of thymoma-associated immunodeficiency: Good syndrome and beyond

13 April 2024
Author(s): Chen Wang, Yiyun Shi, Xin Rong Lim, Jolan E. Walter

Good syndrome (GS) is an acquired adult-onset combined immunodeficiency typically characterized by thymoma and hypogammaglobulinemia. Other clinical manifestations include recurrent infections,... more

Interaction between age and efficacy of dual antiplatelet therapy in non-cardioembolic minor acute ischemic stroke or high-risk transient ischemic attack

9 April 2024
Author(s): Konstantinos G. Kyriakoulis, Ariadni Menti, Eleni Korompoki, George Ntaios, Anastasios Kollias

Short-term (21–90 days) dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel is recommended for patients with minor non-cardioembolic ischemic stroke [National Institutes of Health Stroke... more

Infective endocarditis complicated with heart failure

6 April 2024
Author(s): Baeza-Herrera Luis Augusto, Ruíz-Beltrán Arturo Maximiliano, Alvarado-Alvarado José Alfredo, González-Pacheco Héctor

Infective Endocarditis (IE) is a clinical entity with high morbidity and mortality despite advances in diagnosis and medical and surgical treatment alternatives. Globally, the prevalence is estimated... more

Resuming antiplatelet therapy in patients with intracranial hemorrhage

26 March 2024
Author(s): Asmaa Ahmed, Mohamed Hamed, Mona Mahmoud, Mamas A Mamas, Ayman Elbadawi, APICH

More than a third of adults who experience primary intracranial hemorrhage (ICH) in high-income countries are prescribed antiplatelet medications due to similar risk factors shared with vascular... more

Polyvalent immunoglobulin use: Issues between good use, economic constraints and shortages over 25 years

25 March 2024
Author(s): Q. Perrier, V. Tuloup, C. Chevallier-Brilloit, P. Bedouch, S. Chanoine, Polyvalent immunoglobulin group

Human normal polyvalent immunoglobulins (HNIg) have been widely used for the treatment of primary and secondary immune deficiencies. They also possess immunomodulatory properties and are employed in... more

A prediction model for differentiating recurrent Kawasaki disease from other febrile illnesses

24 March 2024
Author(s): Penghui Yang, Jing Zhang, Siqi Feng, Qijian Yi

Kawasaki disease (KD) can result in coronary artery aneurysms (CAA), elevating the risk of coronary artery thrombosis in the later stage [1]. Intravenous immunoglobulin within the first 10 days after... more

Long-term compliance of lipoprotein apheresis patients. What is health-related quality of life?

23 March 2024
Author(s): Beatrice Dal Pino, Carmen Corciulo, Andrea Ripoli, Federico Bigazzi, Francesco Sbrana

Clinical research and scientific evidence confirm the role of low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp(a)] as a risk factor for atherosclerosis and cardiovascular events.... more

Diagnosis traps for patients with acquired NLRP3 mutation

20 March 2024
Author(s): Margaux Cescato, Laurence Cuisset, Laurent Le Corre, Mathieu P Rodero, Sophie Georgin-Lavialle, on behalf of the F-CAPS study group

Cryopyrinopathies (cryopyrin-associated periodic syndrome, CAPS), also referred to as NLRP3 mutation-associated autoinflammatory diseases (NLRP3-AID), have historically been described as three... more

Antibiotic shortages in Europe: Another question of prices?

16 March 2024
Author(s): L Garattini, B Finazzi, A Mazzone

Pharmaceutical shortages are currently a worldwide issue despite advancement in manufacturing and transport technologies [1]. Surprisingly, shortages still happen in many high-income countries too... more

Changes in the Dynamic Trajectory of Remnant Cholesterol Affect the Occurrence of Nonalcoholic Fatty Liver Disease

14 March 2024
Author(s): Xinlei Miao, Manling Hu, Qianqian Wang, Guimin Tang, Song Leng

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, affecting approximately 20–25 % of the global adult population [1]. Epidemiological evidence showed that,... more

Development and validation of a clinical risk score for all-cause mortality in patients with acquired long QT syndrome

11 March 2024
Author(s): Xiaopeng Dong, Shihao Wang, Cheng Chen, Xiaolei Yang, Yunlong Xia

Dear editor,

Chronic limb-threatening ischemia with no revascularization option: Result from a multidisciplinary care model

11 March 2024
Author(s): Davide Ceccato, Sonia Ragazzo, Francesca Boscaro, Giampiero Avruscio

Lower extremity chronic limb-threatening ischemia (CLTI) is the most advanced form of peripheral arterial disease (PAD). Historically, development of CLTI was associated with 1-year amputation rates... more

Kidney function and sarcopenia: A risk assessment

19 January 2024
Author(s): Tomoyuki Kawada

I read with great interest the paper by Moreno-González et al. [1], who investigated the association between sarcopenia and kidney function in older adults, aged ≥75 years. Estimated glomerular... more

Original Article

Door-to-antibiotic time and mortality in patients with sepsis: Systematic review and meta-analysis

20 July 2024
Author(s): Ling Yan Leung, Hsi-Lan Huang, Kevin KC Hung, Chi Yan Leung, Cherry CY Lam, Ronson SL Lo, Chun Yu Yeung, Peter Joseph Tsoi, Michael Lai, Mikkel Brabrand, Joseph H Walline, Colin A Graham

Timely administration of antibiotics is one of the most important interventions in sepsis management to improve patient outcomes and reduce mortality. However, the impact on mortality of the early... more

Distribution and prognostic impact of different heart failure etiologies in patients with heart failure with mildly reduced ejection fraction

18 July 2024
Author(s): Tobias Schupp, Alexander Schmitt, Felix Lau, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Jonas Rusnak, Kathrin Weidner, Ibrahim Akin, Michael Behnes

As a result of ongoing demographic changes and an ageing population, the overall number of patients with heart failure (HF) has significantly increased. It is estimated that more than 60 million... more

Plasma levels of myeloperoxidase and resistin independently predict mortality in dialysis patients

16 July 2024
Author(s): Luca Liberale, Claudia Torino, Patrizia Pizzini, Sabrina Mezzatesta, Graziella D'Arrigo, Mercedes Gori, Federico Carbone, Elisa Schiavetta, Valeria Cugno, Mara Cabri, Cosimo Sgura, Elia Maioli, Danielle Mbarga, Gianluca Rubini, Amedeo Tirandi, Davide Ramoni, Francesca Mallamaci, Giovanni Tripepi, Carmine Zoccali, Fabrizio Montecucco

Dialysis is a vital treatment for patients with kidney failure on dialysis (KF). Yet, it associates with a high risk of death mainly due to both cardiovascular (CV) and non-CV causes [1,2]. Indeed,... more

A machine learning algorithm for stratification of risk of cardiovascular disease in metabolic dysfunction-associated steatotic liver disease

16 July 2024
Author(s): Naoki Shibata, Yasuhiro Morita, Takanori Ito, Yasunori Kanzaki, Naoki Watanabe, Naoki Yoshioka, Yoshihito Arao, Satoshi Yasuda, Yuichi Koshiyama, Hidenori Toyoda, Itsuro Morishima

Steatotic liver disease (SLD) has emerged as a prevalent and significant condition that contributes to the rising burden of liver diseases worldwide [1]. Given the increasing prevalence of SLD, it is... more

Associations of cannabis use and body mass index–The Coronary Artery Risk Development in Young Adults (CARDIA) study

9 July 2024
Author(s): Julian Jakob, Fiona Schwerdtel, Steve Sidney, Nicolas Rodondi, Mark J. Pletcher, Jared P. Reis, Ranganath Muniyappa, Carole Clair, Kali Tal, Michael P. Bancks, Jamal S. Rana, Tinh-Hai Collet, Reto Auer

In the US in 2020, 18 % of the population reported use of cannabis in the past year. Use among middle and older-aged people is rising [1,2]; from 2016 to 2018 the percentage of US adults ≥55 years... more

Long-term inhaled corticosteroid treatment in patients with chronic obstructive pulmonary disease, cardiovascular disease, and a recent hospitalised exacerbation: The ICSLIFE pragmatic, randomised controlled study

8 July 2024
Author(s): Alberto Papi, Giacomo Forini, Mauro Maniscalco, Elena Bargagli, Claudia Crimi, Pierachille Santus, Antonio Molino, Valeria Bandiera, Federico Baraldi, Silvestro Ennio D'Anna, Mauro Carone, Maurizio Marvisi, Corrado Pelaia, Giulia Scioscia, Vincenzo Patella, Maria Aliani, Leonardo M Fabbri, ICSLIFE Study Group

Patients with chronic obstructive pulmonary disease (COPD) are typically older [1], and have multiple comorbidities, including heart failure, ischaemic heart disease, and arrhythmias [2–5]. The... more

Performance of HAS-BLED and DOAC scores to predict major bleeding events in atrial fibrillation patients treated with direct oral anticoagulants: A report from a prospective European observational registry

4 July 2024
Author(s): Davide Antonio Mei, Jacopo Francesco Imberti, Niccolò Bonini, Giulio Francesco Romiti, Bernadette Corica, Marco Proietti, Marco Vitolo, Gregory Y.H. Lip, Giuseppe Boriani

Atrial fibrillation (AF) is the most common arrhythmia worldwide and it is associated with a 3–5-fold higher risk of stroke [1]. This risk has been significantly reduced after the introduction of... more

Metabolic health and genetic predisposition in inflammatory bowel disease: Insights from a prospective cohort study

2 July 2024
Author(s): Ningning Mi, Qiangsheng He, Yuyao Liu, Yingmei Li, Ying Li, Yingjie Wu, Man Yang, Yingya Zhao, Peng Xie, Wenjing Li, Siqin Wu, Zijun Li, Danni Wang, Xiwen Qin, Jinqiu Yuan, Pingguang Lei, Jian Qi, Bin Xia

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease of the gastrointestinal tract driven by an inappropriate and... more

Effectiveness Of Tocilizumab In Aortitis And Aneurysms Associated With Giant Cell Arteritis

22 June 2024
Author(s): Adrián Martín-Gutiérrez, Javier Loricera, Javier Narváez, Vicente Aldasoro, Olga Maiz, Paloma Vela, Susana Romero-Yuste, Eugenio de Miguel, Eva Galíndez-Agirregoikoa, Jesús C. Fernández-López, Iván Ferraz-Amaro, Julio Sánchez-Martín, Patricia Moya, Cristina Campos, Fernando López-Gutiérrez, Santos Castañeda, Ricardo Blanco, Tocilizumab in Giant Cell Arteritis Spanish Collaborative Group

Giant Cell Arteritis (GCA) is a vasculitis involving the large and medium vessels, especially the extracranial branches of the carotid arteries, and particularly, the temporal artery. Arterial wall... more

Red flags for clinical suspicion of eosinophilic granulomatosis with polyangiitis (EGPA)

15 June 2024
Author(s): R. Solans-Laqué, I. Rúa-Figueroa, M. Blanco Aparicio, I. García Moguel, R. Blanco, F. Pérez Grimaldi, A. Noblejas Mozo, M. Labrador Horrillo, J.M. Álvaro-Gracia, C. Domingo Ribas, G. Espigol-Frigolé, F. Sánchez-Toril López, F.M. Ortiz Sanjuán, E. Arismendi, M.C. Cid

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome [1], is a systemic vasculitis classified as an anti-neutrophil cytoplasm antibody (ANCA)-associated... more

Low-dose ondansetron: A candidate prospective precision medicine to treat alcohol use disorder endophenotypes

13 June 2024
Author(s): Bankole Johnson, Hannu Alho, Giovanni Addolorato, Otto Michael Lesch, Jonathan Chick, Lei Liu, Vinzant Schuyler

Alcohol is an addictive substance that contributes to millions of deaths and disabilities worldwide [1]. Excessive alcohol use accounts for 5.1 % of the global disease burden and is the primary risk... more

Beta-cell function and glucose metabolism in patients with chronic pancreatitis

12 June 2024
Author(s): Gea Ciccarelli, Gianfranco Di Giuseppe, Laura Soldovieri, Giuseppe Quero, Enrico Celestino Nista, Michela Brunetti, Francesca Cinti, Simona Moffa, Umberto Capece, Vincenzo Tondolo, Andrea Mari, Antonio Gasbarrini, Alfredo Pontecorvi, Sergio Alfieri, Andrea Giaccari, Teresa Mezza

Diabetes of the exocrine pancreas (DEP), - also defined as pancreatic, pancreatogenic, or type 3c diabetes - arises from the structural or functional loss of insulin secretion secondary to exocrine... more

Efficacy and safety of rituximab induction therapy and effect of rituximab maintenance for IgG4-related disease: a systematic review and meta-analysis

12 June 2024
Author(s): Yixiao Liu, Kehan Jin, Yingyun Yang, Aiming Yang

IgG4-related disease (IgG4-RD) is a rare systemic fibro-inflammatory condition characterized by widespread lesions that exhibit specific histological characteristics [1]. This disease is typically... more

Diagnosis of acute aortic syndromes with ultrasound and d-dimer: the PROFUNDUS study

12 June 2024
Author(s): Fulvio Morello, Paolo Bima, Matteo Castelli, Elisa Capretti, Alexandre de Matos Soeiro, Alessandro Cipriano, Giorgio Costantino, Simone Vanni, Bernd A. Leidel, Beat A. Kaufmann, Adi Osman, Marcello Candelli, Nicolò Capsoni, Wilhelm Behringer, Marialessia Capuano, Giovanni Ascione, Tatiana de Carvalho Andreucci Torres Leal, Lorenzo Ghiadoni, Emanuele Pivetta, Stefano Grifoni, Enrico Lupia, Peiman Nazerian, PROFUNDUS Study Investigators

Acute aortic syndromes (AASs), including aortic dissection (AD), intramural aortic haematoma (IMH) and penetrating aortic ulcer (PAU), affect 5–7/100,000 individuals/year [1]. They are time-dependent... more

A group-based intervention for diabetes-related emotional distress among emerging adults with type 1 diabetes: A pilot study

8 June 2024
Author(s): Anne-Sofie Kortegaard, Rikke B. Rokkjær, Hanne Marie H. Harboe, Sten Lund, Anette Andersen, Mette Bohl

Emerging adulthood is a critical period with increased risk of acute and chronic health complications, psychological problems, and psychosocial issues for emerging adults with type 1 diabetes (T1D) [... more

Relationship between degree of risk factor control and all-cause mortality in individuals with type 2 diabetes: A prospective cohort study

5 June 2024
Author(s): Monia Garofolo, Giuseppe Penno, Anna Solini, Emanuela Orsi, Martina Vitale, Veronica Resi, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Antonio Nicolucci, Giuseppe Pugliese, Renal Insufficiency And Cardiovascular Events (RIACE) Study Group

Risk of death is approximately twice higher in people with diabetes than in those without, mainly though not exclusively due to an increased risk of cardiovascular disease (CVD) [1]. However, death... more

Association between socioeconomic and psychosocial factors with use of interventional and surgical treatments and outcomes in patients with myocardial infarction – Inpatient data of the largest European health care system

4 June 2024
Author(s): Omar Hahad, Lukas Hobohm, Sadeer Al-Kindi, Volker H. Schmitt, Fawad Kazemi-Asrar, Donya Gilan, Katja Petrowski, Tommaso Gori, Philipp Wild, Klaus Lieb, Andreas Daiber, Philipp Lurz, Thomas Münzel, Karsten Keller

Myocardial infarction (MI) remains a leading contributor for morbidity and mortality worldwide [1,2]. While the medical progress regarding diagnostic and therapeutic approaches has improved outcomes... more

Targets for deprescribing in patients with hypertension and reflex syncope

24 May 2024
Author(s): Antonella Groppelli, Giulia Rivasi, Artur Fedorowski, Frederik de Lange, Vincenzo Russo, Roberto Maggi, Marco Capacci, Sara Nawaz, Angelo Comune, Andrea Ungar, Gianfranco Parati, Michele Brignole

In hypertensive patients with reflex syncope, detection of transient hypotension as possible trigger mechanism of syncope may prompt deprescribing of hypotensive medications to counteract the risk of... more

Early palliative care program in idiopathic pulmonary fibrosis patients favors at-home and hospice deaths, reduces unplanned medical visits, and prolongs survival: A pilot study

23 May 2024
Author(s): Ilaria Bassi, Stefania Pastorello, Aldo Guerrieri, Gilda Giancotti, Anna Maria Cuomo, Chiara Rizzelli, Maria Coppola, Danila Valenti, Stefano Nava

Idiopathic Pulmonary Fibrosis (IPF) is a relentlessly progressive fibrotic interstitial lung disease (ILD) with an unfavourable prognosis1. The median survival is 3 to 5 years form the time of... more

Comparison of different frailty instruments for prediction of functional decline in older hypertensive outpatients (HYPER-FRAIL pilot study 2)

18 May 2024
Author(s): Giulia Rivasi, Ludovica Ceolin, Giada Turrin, Virginia Tortù, Maria Flora D'Andria, Marco Capacci, Giuseppe Dario Testa, Sara Montali, Francesco Tonarelli, Enrico Brunetti, Mario Bo, Roman Romero-Ortuno, Enrico Mossello, Andrea Ungar

Frailty is a geriatric syndrome characterized by a cumulative decline in multiple body systems, which results in the reduction of individuals’ physiological functional reserve with increased... more

Combining loop with thiazide diuretics in patients discharged home after a heart failure decompensation: Association with 30-day outcomes

18 May 2024
Author(s): Òscar Miró, Julio Núñez, Joan Carles Trullàs, Pedro Lopez-Ayala, Lluís Llauger, Aitor Alquézar-Arbé, Gema Miñana, Anna Mollar, Rafael de la Espriella, Miguel Lorenzo, Javier Jacob, Begoña Espinosa, Vanesa Garcés-Horna, Alfons Aguirre, María José Fortuny, Gemma Martínez-Nadal, Víctor Gil, Christian Mueller, Pere Llorens, ICA-SEMES, INCLIVA, ALCALOTIC research groups

Heart failure (HF) is a highly prevalent cardiovascular condition in people over 65 years old [1]. Mortality associated with HF decompensations (acute HF; AHF) is high, with 30-day and 1-year all-... more

Acute kidney injury predicts mortality in very elderly critically-ill patients

14 May 2024
Author(s): Elisa Alba Schmidt, Silvia De Rosa, Jakob Müller, Paul Hüsing, Rikus Daniels, Pauline Theile, Nils Schweingruber, Stefan Kluge, Tobias B. Huber, Kevin Roedl, Christian Schmidt-Lauber

The age of patients admitted to intensive care units (ICUs) has witnessed a significant increase in the last decades. Recent statistics reveal that ten to fifteen percent of ICU-admitted patients are... more

Effects of a medical admission unit on in-hospital patient flow and clinical outcomes

11 May 2024
Author(s): Ciro Canetta, Silvia Accordino, Elisa La Boria, Gianpiero Arosio, Silvia Cacco, Pietro Formagnana, Michela Masotti, Stella Provini, Sonia Passera, Giovanni Viganò, Fabiola Sozzi

In the last decades the epidemiological transition has brought to several acute complex (elderly, frail and poli-pathological) patients that access to Emergency Departments (ED) and require... more

Development and validation of a novel sleep health score in the sleep heart health study

9 May 2024
Author(s): Muqi Xing, Lingzhi Zhang, Jiahui Li, Zihan Li, Qi Yu, Wenyuan Li

Sleep is closely related to health [1]. Middle-aged and elderly people, especially the elderly, often suffer from sleep disorders, such as sleep apnea and insomnia [2]. These sleep disorders likely... more

Cardiovascular events after exacerbations of chronic obstructive pulmonary disease: Results from the EXAcerbations of COPD and their OutcomeS in CardioVascular diseases study in Italy

9 May 2024
Author(s): Silvia Calabria, Giulia Ronconi, Letizia Dondi, Leonardo Dondi, Irene Dell'Anno, Clementine Nordon, Kirsty Rhodes, Paola Rogliani, Francesco Dentali, Nello Martini, Aldo Pietro Maggioni

Chronic obstructive pulmonary disease (COPD) is a chronic progressive disorder of the lungs with high global morbidity and mortality [1]. The burden and prevalence of COPD are increasing likely due... more

C-reactive protein is more suitable than Serum Amyloid A to monitor crises and attack-free periods in Systemic Auto-Inflammatory Diseases.

8 May 2024
Author(s): Anne-Sophie Parentelli, Anne-Aurélie Lopes, Soraya Fellahi, Léa Savey, Jean-Philippe Bastard, Sophie Georgin-Lavialle

Systemic Auto-Inflammatory Diseases (SAID) are diseases with a deregulation of the innate inflammatory response characterized by recurrent fever episodes with systemic inflammation without infectious... more

Hepatic T1-time, cardiac structure and function and cardiovascular outcomes in patients with dilated cardiomyopathy

7 May 2024
Author(s): Riccardo M. Inciardi, Marco Merlo, Mariagiulia Bellicini, Martina Setti, Antonio De Luca, Nunzia Di Meo, Paolo Rondi, Matteo Pagnesi, Marianna Adamo, Carlo M. Lombardi, Jacopo Giulio Rizzi, Davide Farina, Alessandro Mantovani, Giovanni Targher, Gianfranco Sinagra, Marco Metra, NAFLD-DCM group

Liver damage frequently occurs in patients with cardiovascular (CV) disease and predicts worse clinical outcomes [1,2]. In this context, liver damage may be mainly caused by elevated hepatic venous... more

Incidence and predisposing factors of extra-articular manifestations in contemporary rheumatoid arthritis

4 May 2024
Author(s): Lotta Ljung, Elias Jönsson, Johan Franklin, Ewa Berglin, Anders Lundquist, Solbritt Rantapää-Dahlqvist

Rheumatoid arthritis (RA) is the most prevalent of the chronic inflammatory joint diseases, with gradual destruction of joints and an increased risk of co-morbidity, predominantly cardiovascular... more

Consecutive or selectively included high bleeding risk patients in the MASTER DAPT screening log and trial

3 May 2024
Author(s): Antonio Landi, Dik Heg, Enrico Frigoli, Pim A.L. Tonino, Pascal Vranckx, Suzanne Pourbaix, Bernard Chevalier, Andrés Iñiguez, Eduardo Pinar, Maciej Lesiak, Petr Kala, Michael Donahue, Stephan Windecker, Marco Roffi, Pieter C. Smits, Marco Valgimigli, MASTER DAPT Investigators

Screening logs have the potential to appraise the actual prevalence and distribution of predefined patient subsets, avoiding selection biases, which are inevitably and potentially present in... more

Iron deficiency and all-cause mortality after myocardial infarction

1 May 2024
Author(s): Dominik Jenča, Vojtěch Melenovský, Jolana Mrázková, Marek Šramko, Martin Kotrč, Michael Želízko, Věra Adámková, Jan Piťha, Josef Kautzner, Peter Wohlfahrt

Iron is an essential element required for normal mitochondrial function [1,2] oxygen transport, synthesis of proteins and nucleic acids, and normal immune system function. Although iron is... more

Direct oral anticoagulant-associated bleeding complications in patients with gastrointestinal cancer and venous thromboembolism

24 April 2024
Author(s): Yuji Nishimoto, Yugo Yamashita, Takeshi Morimoto, Ryuki Chatani, Kazuhisa Kaneda, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Yukihito Sato, Tetsuya Watanabe, Takahisa Yamada, Masatake Fukunami, Takeshi Kimura, COMMAND VTE Registry-2 Investigators

Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), constitutes the second leading cause of morbidity and mortality in patients with cancer besides the... more

Serum IL-6 level trajectory for predicting the effectiveness and safety of tocilizumab in the treatment of refractory Takayasu arteritis

21 April 2024
Author(s): Xiaochuan Sun, Chenglong Fang, Shangyi Jin, Jing Li, Yunjiao Yang, Xiaofeng Zeng, Xinping Tian

Takayasu arteritis (TAK) is a chronic systemic granulomatous vasculitis that mainly affects aorta and its major branches in young women [1]. The inflammatory damage of arteries can develop... more

Cardio-protective effects of statins in patients undergoing anthracycline-based chemotherapy: An updated meta-analysis of randomized controlled trials

19 April 2024
Author(s): Nicole Felix, Paula C. Nogueira, Isadora M. Silva, Thomaz Alexandre Costa, Carlos Alberto Campello, Carlos Stecca, Renato D. Lopes

Cancer and cardiovascular disease are two leading causes of mortality worldwide, and cancer survivors have an increased cardiovascular risk due to shared risk factors with cardiovascular disease and... more

Prognostic value of 18 FDG-PET at diagnosis and follow-up in giant cell arteritis: An observational restrospective study

15 April 2024
Author(s): Anne-Claire Billet, Thomas Thibault, Éric Liozon, Hubert De Boysson, Laurent Perard, Olivier Espitia, Aurélie Daumas, Quentin Gomes De Pinho, Cécile-Audrey Durel, Arnaud Hot, Boris Bienvenu, Sébastien Humbert, Claude Bachmeyer, Sabine Mainbourg, Thomas Sené, Hervé Devilliers, Bastien Durand Bailloud, Hélène Greigert, Alexandre Cochet, Bernard Bonnotte, Jean-Louis Alberini, Maxime Samson, French Study Group for Large Vessel Vasculitis (GEFA)

To evaluate the ability of 18FDG PET/CT, at diagnosis of giant cell arteritis (GCA) and during follow-up, to predict occurrence of relapse in large-vessel GCA (LV-GCA).

Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score

15 April 2024
Author(s): Roberto Bernabéu-Mora, Silvana Loana Oliveira-Sousa, Francesc Medina-Mirapeix, Mariano Gacto-Sánchez, Group of Investigation SAQ_COPD

Chronic obstructive pulmonary disease (COPD) is a heterogeneous and systemic condition characterized by chronic respiratory symptoms (dyspnea, cough, sputum production) due to abnormalities of the... more

Prognostic impact of hypertension grading

14 April 2024
Author(s): Fabio Angeli, Paolo Verdecchia, Gianpaolo Reboldi

Notwithstanding the continuous relation between blood pressure (BP) and the risk of cardiovascular disease [1,2], Guidelines generally grade hypertension in untreated subjects by arbitrary categories... more

Prognostic value of cognitive impairment, assessed by the Clock Drawing Test, in emergency department patients presenting with non-specific complaints

10 April 2024
Author(s): Tanguy Espejo, Nadja Wagner, Henk B. Riedel, Julia Karakoumis, Nicolas Geigy, Christian H. Nickel, Roland Bingisser

Cognitive impairment (CI) is common among older patients presenting to the emergency department (ED) [1–6]. Up to 40% of older ED patients have some degree of CI at presentation, particularly due to... more

Clinical significance of the anti-Nucleolar Organizer Region 90 antibodies (NOR90) in systemic sclerosis: Analysis of the European Scleroderma Trials and Research (EUSTAR) cohort and a systematic literature review

9 April 2024
Author(s): A Dima, MC Vonk, A Garaiman, BE Kersten, R Becvar, M Tomcik, A-M Hoffmann-Vold, I Castellvi, JL Tandaipan Jaime, M Brzosko, M Milchert, D Krasowska, M Michalska-Jakubus, P Airo, M Matucci-Cerinic, C Bruni, M Iudici, JHW Distler, AM Gheorghiu, H Poormoghim, F Motta, M De Santis, M Parvu, O Distler, C Mihai

The anti-Nucleolar Organizer Region 90 antibodies (NOR90) are rare antinuclear antibodies (ANA) reported in systemic sclerosis (SSc). Especially due to low prevalence, the clinical relevance of NOR90... more

Evolution and outcomes of aortic dilations in giant cell arteritis

5 April 2024
Author(s): Sophie Gallou, Christian Agard, Anael Dumont, Samuel Deshayes, Jonathan Boutemy, Gwénola Maigné, Nicolas Martin Silva, Alexandre Nguyen, Rémi Philip, Olivier Espitia, Achille Aouba, Hubert de Boysson

Giant cell arteritis (GCA) is a systemic vasculitis that typically affects large and medium vessels in patients over 50 years of age [1–3]. In addition to the cephalic presentation mainly explained... more

Relation of plasma neuropeptide-Y with myocardial function and infarct severity in acute ST-elevation myocardial infarction

29 March 2024
Author(s): Christina Tiller, Martin Reindl, Magdalena Holzknecht, Ivan Lechner, Felix Troger, Fritz Oberhollenzer, Sebastian von der Emde, Thomas Kremser, Agnes Mayr, Axel Bauer, Bernhard Metzler, Sebastian J Reinstadler

Acute myocardial infarction is associated with high levels of cardiac sympathetic stimulation [1], which is strongly related to poor outcome [2]. Prolongation of this sympathetic drive leads to the... more

The interplay between subclinical hypothyroidism and poor sleep quality: A systematic review

28 March 2024
Author(s): Marsida Teliti, Francesco Fanfulla, Laura Croce, Francesca Coperchini, Mario Rotondi

Sleep and the hypothalamic-pituitary-thyroid (HPT) axis show a mutual interdependence in normal physiological functioning [1]. While the interconnection between overt hypo- and hyperthyroidism and... more

Serum potassium abnormalities, renin-angiotensin-aldosterone system inhibitor discontinuation, and clinical outcomes in patients with chronic cardiovascular, metabolic, and renal conditions: A population-based analysis

27 March 2024
Author(s): Santiago Jiménez-Marrero, Miguel Cainzos-Achirica, David Monterde, Emili Vela, Cristina Enjuanes, Sergi Yun, Alberto Garay, Pedro Moliner, Miriam Corbella, Sílvia Jovells-Vaqué, Lídia Alcoberro, Alexandra Pons-Riverola, Raul Ramos-Polo, Herminio Morillas, Joan Antoni Gómez-Hospital, Josep Comin-Colet

The inhibition of the renin-angiotensin-aldosterone system (RAAS) is a essential aspect of the medical treatment of several chronic cardiovascular, metabolic, and renal conditions. It plays a vital... more

Sex-based differences in the comprehensive geriatric assessment in elderly hospitalized patients with non-valvular atrial fibrillation

27 March 2024
Author(s): Giuseppe Armentaro, Daniele Pastori, Alberto Castagna, Valentino Condoleo, Velia Cassano, Carlo Alberto Pastura, Mattea Francica, Caterina Benincasa, Nicola D'Alterio, Franco Arturi, Giovanni Ruotolo, Angela Sciacqua

Atrial fibrillation (AF) represents the most common supraventricular arrhythmia in elderly [1]. It was estimated that 1 % to 3 % of the world population suffers from AF, with higher prevalence in the... more

The correlation of atherogenic index of plasma with non-obstructive CAD and unfavorable prognosis among patients diagnosed with MINOCA

26 March 2024
Author(s): Fuad A. Abdu, Jiasuer Alifu, Abdul-Quddus Mohammed, Lu Liu, Wen Zhang, Guoqing Yin, Xian Lv, Ayman A. Mohammed, Redhwan M. Mareai, Yawei Xu, Wenliang Che

Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a complex and intriguing phenomenon with diverse underlying pathophysiological mechanisms that challenge conventional... more

Recurrence of hypertriglyceridemia-associated acute pancreatitis: A multicenter, prospective cohort study

26 March 2024
Author(s): Ling Ding, Shuai Li, Longxiang Cao, Lanting Wang, Jing Zhou, Wenjian Mao, Weiqin Li, Yin Zhu, Lu Ke, the Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG)

Hypertriglyceridemia (HTG) is a well-established etiology of acute pancreatitis (AP), accounting for approximately 4.7–14.3 % of all cases globally [1,2]. Recurrent acute pancreatitis (RAP) is one of... more

Safety and compliance of long-term low-dose ondansetron in alcohol use disorder treatment.

23 March 2024
Author(s): Giovanni Addolorato, Hannu Alho, Paula Bresciani M․ De Andrade, Otto Michael Lesch, Lei Liu, Bankole Johnson

There are geographical differences regarding alcohol-associated morbidity and mortality, the WHO European Region being the most affected area [1]. Europe leads globally in per capita alcohol... more

Visit-to-visit blood pressure variability is associated with intrinsic capacity decline: Results from the MAPT Study

18 March 2024
Author(s): Leonardo Bencivenga, Mathilde Strumia, Yves Rolland, Sophie Guyonnet, Angelo Parini, Philippe Cestac, Sandrine Andrieu, Philipe De Souto Barreto, Laure Rouch, For the MAPT/DSA group

Blood Pressure (BP) values fluctuate over time around average values, as a consequence of the interaction between multiple intrinsic and environmental factors affecting the cardiovascular system [1... more

Early and accurate diagnosis of steatotic liver by artificial intelligence (AI)-supported ultrasonography

14 March 2024
Author(s): Sergio Santoro, Mohamad Khalil, Hala Abdallah, Ilaria Farella, Antonino Noto, Giovanni Marco Dipalo, Piercarlo Villani, Leonilde Bonfrate, Agostino Di Ciaula, Piero Portincasa

Nonalcoholic fatty liver disease (NAFLD) refers to liver steatosis, i.e., over-storage of fat, mainly triglycerides, in the hepatocytes, without other causes for secondary hepatic fat accumulation [1... more

Prognosis of COVID-19 severity using DERGA, a novel machine learning algorithm

8 March 2024
Author(s): Panagiotis G. Asteris, Amir H. Gandomi, Danial J. Armaghani, Styliani Kokoris, Anastasia T. Papandreadi, Anna Roumelioti, Stefanos Papanikolaou, Markos Z. Tsoukalas, Leonidas Triantafyllidis, Evangelos I. Koutras, Abidhan Bardhan, Ahmed Salih Mohammed, Hosein Naderpour, Satish Paudel, Pijush Samui, Ioannis Ntanasis-Stathopoulos, Meletios A. Dimopoulos, Evangelos Terpos

The Coronavirus Disease 2019 (COVID-19) pandemic, caused by the novel coronavirus Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2), has had a profound impact on healthcare systems... more

A systematic literature review of randomised controlled trials evaluating colchicine for cardiovascular prevention: There is an elephant in the room

2 January 2024
Author(s): Alessia Alunno, Francesco Carubbi, Cecilia Martini, Veronica Moronti, Jessica Santilli, Jan W Schoones, Francesco Maria Mariani, Evy Di Ruscio, Piera Altieri, Claudio Ferri

Gout is a chronic inflammatory disease burdened by a higher CV risk compared to the general population [1] and this excess risk cannot be explained only by the prevalence of traditional risk factors... more

Practice Guidelines

2024 European Society of Hypertension clinical practice guidelines for the management of arterial hypertension

24 June 2024
Author(s): Reinhold Kreutz, Mattias Brunström, Michel Burnier, Guido Grassi, Andrzej Januszewicz, Maria Lorenza Muiesan, Konstantinos Tsioufis, Rosa Maria de Pinho, Fabio Lucio Albini, Jean-Marc Boivin, Michalis Doumas, János Nemcsik, Enrique Rodilla, Enrico Agabiti-Rosei, Engi Abd Elhady Algharably, Giancarlo Agnelli, Athanase Benetos, Jana Brguljan Hitij, Renata Cífková, Véronique Cornelissen, A.H. Jan Danser, Christian Delles, Ricardo Gómez Huelgas, Zoltán Járai, Paolo Palatini, Atul Pathak, Alexandre Persu, Jorge Polonia, Pantelis Sarafidis, George Stergiou, Costas Thomopoulos, Christoph Wanner, Thomas Weber, Bryan Williams, Sverre E. Kjeldsen, Giuseppe Mancia

The European Society of Hypertension (ESH) reported in 2023 its current Guidelines for the management of arterial hypertension [1]. Following their aim to summarize the best available evidence for... more

Review Article

Exploring the nexus: The place of kidney diseases within the cardiovascular-kidney-metabolic syndrome spectrum

18 July 2024
Author(s): Mehmet Kanbay, Mustafa Guldan, Lasin Ozbek, Sidar Copur, Andreea Simona Covic, Adrian Covic

Metabolic syndrome (MS) or Cardiovascular-Kidney-Metabolic (CKM) syndrome, the global epidemic with prevalence increasing from 25.3 % in 1988–1994 to 34.2 % in 2007–2012 in the adult population of... more

East meets West: Bringing the ESH 2023 hypertension guidelines into Asia

2 July 2024
Author(s): Apichard Sukonthasarn, Claudio Borghi, Yu Ho Chan, Federick Cheng, Hyo-In Choi, Radhika Mehta, Binh Le, Ing Haan Lim, Tsing-Hsien Lin, Azhari Rosman, Badai Bhatara Tiksnadi, Athanasios Manolis

Hypertension remains a major problem worldwide, especially across the Asia-Pacific region. According to The NCD Risk Factor Collaboration, which analysed data from 1990 to 2019 on people aged 30–79... more

What should I eat today? Evidence, guidelines, dietary patterns and consumer's behavior

30 May 2024
Author(s): Carlo Agostoni, Stefania Boccia, Guendalina Graffigna, Joanne Slavin, Martina Abodi, Hania Szajewska

The modern science of nutrition, starting from its origins more than one century and a half ago, initially has been strictly confined to the concepts of dietary requirements. These included energy... more

Single-pill combination for treatment of hypertension: Just a matter of practicality or is there a real clinical benefit?

22 April 2024
Author(s): A Coca, SP Whelton, M Camafort, JP López-López, E Yang

Cardiovascular disease (CVD) represents the leading cause of morbidity and mortality worldwide resulting in approximately one third of all deaths globally [1,2]. Despite significant advances in... more

Type 1 diabetes-related distress: Current implications in care

11 April 2024
Author(s): Alba Rodríguez-Muñoz, María José Picón-César, Francisco J. Tinahones, José Ignacio Martínez-Montoro

Type 1 diabetes (T1D) is a complex and demanding chronic disease characterized by a severe lack of insulin synthesis which needs to be supplied exogenously [1,2]. In this context, people living with... more

Metabolic Bariatric surgery in People with Obesity aged ≥65 Years

30 March 2024
Author(s): Nursel Çalık Başaran, Dana Marcoviciu, Dror Dicker

The World Health Organization (WHO) estimated that 1.4 billion people in the world will be aged 60 years and older in 2030 and 2.1 billion by 2050, comprising 12–22 % of the global population [1].... more

Gender-specific insights into the irritable bowel syndrome pathophysiology. Focus on gut dysbiosis and permeability

10 March 2024
Author(s): Jerlin Stephy JohnBritto, Agostino Di Ciaula, Antonino Noto, Velia Cassano, Angela Sciacqua, Mohamad Khalil, Piero Portincasa, Leonilde Bonfrate

Irritable bowel syndrome (IBS), a chronic functional gastrointestinal disorder, manifests through recurrent episodes of abdominal pain or discomfort, coupled with variations in bowel habits... more

The impact of colchicine on patients with acute and chronic coronary artery disease

17 January 2024
Author(s): Mehdi Madanchi, Mabelle Young, Gregorio Tersalvi, Giacomo Maria Cioffi, Adrian Attinger-Toller, Florim Cuculi, Reto Kurmann, Matthias Bossard

Inflammation is a major contributor in the development and progression of coronary artery disease (CAD). Preclinical studies have demonstrated that inflammatory processes, by means of specific... more


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