Familial hypercholesterolemia (FH) is the most common disorder of lipid metabolism and can be caused by defects in different genes that code for proteins involved in hepatic clearance of low-density lipoprotein-cholesterol (LDL-C). FH subjects may develop premature atherosclerotic cardiovascular disease and they have a much higher risk of dying from a coronary event than do the general population [1]. In addition, FH patients appear to have an increased risk of cognitive impairment in old age [2,3].
