Published: 30 May 2018
Author(s): Alessandro Allegra, Vanessa Innao, Demetrio Gerace, Andrea Gaetano Allegra, Doriana Vaddinelli, Oriana Bianco, Caterina Musolino
Issue: June 2018
Section: Narrative Review Article

In addition to its capacity to store lipids the adipose tissue is now identified as a real organ with both endocrine and metabolic roles.Preclinical results indicate that modifying adipose tissue and bone marrow adipose tissue (BMAT) could be a successful multiple myeloma (MM) therapy. BMAT interrelates with bone marrow cells and other immune cells, and may influence MM disease progression. The BM adipocytes may have a role in MM progression, bone homing, chemoresistance, and relapse, due to local endocrine, paracrine, or metabolic factors.

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