June 2022

31 Articles

No Section

Is malignancy cancer an adverse factor of in-hospital clinical outcome in post-cardiac arrest?

16 February 2022
Author(s): Jun Chen, Mei Yu, Rui Zeng, Yimin Wang, Qiang Liu

With the continuous development of cancer treatment, patients with cancer have dramatically improved, with several cancer populations experiencing a median survival well beyond 5 years.1 However,... more

Double-gloving in an Intensive Care Unit during the COVID-19 pandemic

13 February 2022
Author(s): Ori Galante, Abraham Borer, Yaniv Almog, Lior Fuchs, Lisa Saidel-Odes

Dear Editor,

Clinical Insights

Anticoagulation as secondary prevention of massive lung thromboses in hospitalized patients with COVID-19

12 April 2022
Author(s): Rosaria Sofia, Mattias Carbone, Giovanni Landoni, Alberto Zangrillo, Lorenzo Dagna

Since February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been responsible for one of the major pandemic we have experienced in the last 100 years [1]. The most... more

Commentary

Dual antiplatelet treatment for minor acute ischemic stroke and high-risk transient ischemic attack: have we reached the limit of antithrombotic management?

18 April 2022
Author(s): Georgios Tsivgoulis, Aristeidis H. Katsanos

In this issue of the European Journal of Internal Medicine Pomero et al. present their systematic review and meta-analysis evaluating the early use of clopidogrel and ticagrelor in addition to... more

Ultrasound evaluation of bowel vasculopathy in systemic sclerosis but…

12 April 2022
Author(s): Isabel Almeida, João Amorim, Carlos Vasconcelos

The gastrointestinal (GI) tract is affected in up to 90% of patients with systemic sclerosis (SSc). SSc is a key contributor to impairment and disability, leading to remarkable abnormal social... more

The importance of consensus statements on the prevention and treatment of cancer-associated thrombosis

28 March 2022
Author(s): M Carrier, TF Wang

Venous thromboembolism (VTE) is a common complication among patients with cancer. The 6-month risk of VTE complication for cancer patients is 12-fold higher and as much as 23-fold higher in those... more

The unresolved issues in the management of mucormycosis

26 March 2022
Author(s): Frederic Lamoth

Mucormycosis represents the second most frequent invasive mold infection after invasive aspergillosis and its incidence tends to increase around the world [1]. The disease not only affects patients... more

Ideas and Opinions

Reflections on experimentation in medicine

5 April 2022
Author(s): Tilman Sauerbruch

Empirical medicine – over centuries - has been based on close observation of the patient`s history and the sick body. Thus, the ancient Greeks had already concepts of human anatomy, organ functions... more

Internal Medicine Flashcard

Diffuse pulmonary ill-defined centrilobular opacities: Not only bronchiolitis

25 March 2022
Author(s): S Piciucchi, V Poletti

metastatic pulmonary calcification

Chilblain-like acral lesions

22 March 2022
Author(s): Hanlin Yin, Liangjing Lu

A 70-year-old Asian female presented to the rheumatology clinic with a 5-year history of tender papules on fingers and toes aggravated under cold exposure. She also reported polyarthralgia and... more

Granulomatous lesions of the skin: Do not fall into the trap

21 March 2022
Author(s): E. Hoornaert, L. Marot, H. Yildiz

A 51-year-old woman was referred to investigate skin lesions present on her backside.

A man with fever and aortitis

21 March 2022
Author(s): Nana Akazawa, Naoya Itoh, Masashi Ando

A 54-year-old man presented with a chief complaint of fever and pain around the left clavicle. He had a primary germ cell tumor of the mediastinum and had been undergoing chemotherapy for... more

Letter to the Editor

Doubtful clinical benefit of casirivimab-imdevimab treatment for disease severity outcome of high-risk patients with SARS-CoV-2 delta variant infection

13 March 2022
Author(s): Noah Shopen, Michal Dekel, Michal Mizrahi, Efrat Zandberg, Daniel Talmud, Neta Cohen, Tel Aviv Sourasky Medical Center Emergency Department study group

To the editor,

Assessment of the clinical characteristics of ampicillin-susceptible Enterococcus faecium infection

12 March 2022
Author(s): Hiroshi Ito, Masahiro Watanabe, Ryoko Ogawa, Nobutake Shimojo

Dear Editor,

Health-care associated infections surveillance in elderly patients

8 March 2022
Author(s): Andrea Zanichelli, Stefano Pietro Sgobba, Andrea Merlo, Chiara Beatrice Cogliati

Dear Editor, according with the WHO, Health-Care Associated Infections (HCAIs) are the most frequent adverse events during care delivery and represent a great clinical and economic burden [1]. In... more

Diabetes influences the performance of creatinine-based equations for estimating glomerular filtration rate in the elderly population

20 February 2022
Author(s): Yuanyuan Jiao, Shimin Jiang, Jiahui Zhou, Danyang Zhang, Wenge Li

The number of people older than 65 years with diabetes was 135.6 million in 2019, and will reach 276.2 million by 2045 [1]. Additionally, the estimated prevalence of diabetes in adults today has... more

Impact of therapeutic plasma exchange on acquired vaccinal anti-SARS-CoV-2 antibodies

13 February 2022
Author(s): Catherine Lambert, Anais Scohy, Jean Cyr Yombi, Eric Goffin, Arnaud Devresse

As of December 2021, more than 276 million affected cases and 5 million deaths were reported by the World Health Organization, due to the COVID-19 pandemic [1]. Following the outbreak's beginning,... more

Is the number of long-term post-COVID symptoms relevant in hospitalized COVID-19 survivors?

13 February 2022
Author(s): César Fernández-de-las-Peñas, Umut Varol, Stella Fuensalida-Novo, Susana Plaza-Canteli, Juan Antonio Valera-Calero

Dear editor,

Perspectives of European internists on multimorbidity. A multinational survey

11 February 2022
Author(s): M Bernabeu-Wittel, M Holecki, A Tuttolomondo, J Chudek, E Battegay, on behalf of the EFIM Multimorbidity Working Group

Dear Editor,

Original Article

Effects of non-invasive respiratory supports on inspiratory effort in moderate-severe COVID-19 patients. A randomized physiological study

21 April 2022
Author(s): Gioacchino Schifino, Maria L Vega, Lara Pisani, Irene Prediletto, Vito Catalanotti, Vittoria Comellini, Ilaria Bassi, Maurizio Zompatori, Marco Vito Ranieri, Stefano Nava

Non-invasive respiratory support (NRS), such as, Continuous Positive Airway Pressure (CPAP), High Flow Nasal Cannula (HFNC) or non-invasive ventilation (NIV), have been successfully applied to manage... more

Asymptomatic coronary artery disease assessed by coronary computed tomography in patients with systemic lupus erythematosus: A systematic review and meta-analysis

8 April 2022
Author(s): Claudia Mendoza-Pinto, Pamela Munguía-Realpzo, Mario García-Carrasco, Karla Godinez-Bolaños, Adriana Rojas-Villarraga, Ivet Morales-Etchegaray, Jorge Ayón-Aguilar, Socorro Méndez-Martínez, Ricard Cervera

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with female predominance: cardiovascular disease (CVD) is the leading cause of morbidity and mortality. Accelerated atherosclerosis... more

Reconsidering the Edelman equation: impact of plasma sodium concentration, edema and body weight

4 April 2022
Author(s): Jetta J. Oppelaar, Mart D. Vuurboom, Eliane F.E. Wenstedt, Frans J. van Ittersum, L. Vogt, Rik H.G. Olde Engberink

Hypernatremia and hyponatremia, are commonly encountered electrolyte disturbances in clinical practice [1,2]. The pathophysiology underlying these disturbances is complex and clinicians often face... more

Non-alcoholic fatty liver disease: identical etiologic factors in patients with type 1 and type 2 diabetes

3 April 2022
Author(s): Marieke de Vries, Fatima El-Morabit, Karel J. van Erpecum, Jan Westerink, Simon T. Bac, H.A.H. (Karin) Kaasjager, Harold W. de Valk

Alongside the obesity-epidemic, non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide, with an estimated prevalence of 25% in the general population [1... more

Incidence of endocrine and exocrine insufficiency in patients with autoimmune pancreatitis at diagnosis and after treatment: a systematic review and meta-analysis

30 March 2022
Author(s): Marco Lanzillotta, Matteo Tacelli, Massimo Falconi, Paolo Giorgio Arcidiacono, Gabriele Capurso, Emanuel Della-Torre

Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis that can lead to end-stage organ damage if left untreated [1]. To date, at least two different subtypes of AIP have been... more

P2Y12 inhibitors plus aspirin for acute treatment and secondary prevention in minor stroke and high-risk transient ischemic attack: A systematic review and meta-analysis

21 March 2022
Author(s): Fulvio Pomero, Eleonora Galli, Marta Bellesini, Lorenzo Maroni, Alessandro Squizzato

Stroke is a leading cause of mortality and disability worldwide [1] and approximately 20 to 25% of ischemic stroke are anticipated by transient ischemic symptoms [2]. The risk of ischemic stroke... more

Association between admission ECG changes and long-term mortality in patients with an incidental myocardial infarction: Results from the KORA myocardial infarction registry

19 March 2022
Author(s): Timo Schmitz, Bastian Wein, Heiko Methe, Jakob Linseisen, Margit Heier, Annette Peters, Christa Meisinger

Acute myocardial infarction (AMI) is a major cause of morbidity and mortality in Germany and worldwide [1,2]. It is grouped into two main categories according to admission ECG: ST-Elevation... more

Survival in rhino-orbito-cerebral mucormycosis: An international, multicenter ID-IRI study

15 March 2022
Author(s): Yasemin Cag, Hakan Erdem, Mehmet Gunduz, Suheyla Komur, Handan Ankarali, Serap Ural, Meltem Tasbakan, Pierre Tattevin, Anil Tombak, Derya Ozturk-Engin, Ayse Sagmak Tartar, Ayse Batirel, Recep Tekin, Fazilet Duygu, Hulya Caskurlu, Behice Kurtaran, Bulent Durdu, Demet Haciseyitoglu, Jordi Rello, ID-IRI Mucormycosis Study Group

Mucormycosis is an aggressive mold infection that mostly attacks patients with certain underlying conditions such as diabetes, hematological malignancies, neutropenia, major solid organ... more

Consensus on prevention and treatment of cancer-associated thrombosis (CAT) in controversial clinical situations with low levels of evidence

25 February 2022
Author(s): Paula Jiménez-Fonseca, Enrique Gallardo, Fernando Arranz Arija, Jesús Manuel Blanco, Ana Callejo, Diego Cacho Lavin, Marinha Costa Rivas, Joaquín Mosquera, Alberto Rodrigo, Raúl Sánchez Morillas, María Vares Gonzaléz, Andrés Muñoz, Alberto Carmona-Bayonas

Venous thromboembolism (VTE) is a leading cause of morbidity and mortality among cancer patients. They develop more VTE than those without cancer and experience higher rates of VTE recurrence and... more

Ultrasound evaluation of bowel vasculopathy in systemic sclerosis

17 January 2022
Author(s): Giulia Bandini, Laura Cometi, Esterita Accogli, Andrea Domanico, Lorenzo Tofani, Cosimo Bruni, Silvia Bellando-Randone, Gemma Lepri, Martina Orlandi, Serena Guiducci, Khadija El-Aoufy, Gabriele Ciuti, Alessia Fabbri, Marco Matucci-Cerinic, Alberto Moggi-Pignone, Study Group of Rheumathology and Internal Medicine

Systemic sclerosis (SSc) is a complex disease with a heterogenous clinical spectrum and a complex pathophysiology characterized by immune activation and diffuse microvascular injury resulting in... more

Review Article

Sodium glucose cotransporter-2 inhibitors protect the cardiorenal axis: Update on recent mechanistic insights related to kidney physiology

9 April 2022
Author(s): Charlotte C. van Ruiten, Anne C. Hesp, Daniël H. van Raalte

Diabetic kidney disease (DKD) is a common complication of diabetes, affecting ∼ 40% of patients with type 2 diabetes (T2D) [1]. DKD is characterized by increased urinary albumin excretion and/or... more

Adult anaphylaxis: A state-of-the-art review

6 March 2022
Author(s): Carlo Maria Rossi, Marco Vincenzo Lenti, Antonio Di Sabatino

Anaphylaxis is an acute, usually rapidly developing, systemic (involving multiple organs) allergic reaction and, among the various clinical forms of allergy, it is the most severe and potentially... more

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