Published: 21 April 2022
Author(s): Gioacchino Schifino, Maria L Vega, Lara Pisani, Irene Prediletto, Vito Catalanotti, Vittoria Comellini, Ilaria Bassi, Maurizio Zompatori, Marco Vito Ranieri, Stefano Nava
Issue: June 2022
Section: Original article

Non-invasive respiratory support (NRS), such as, Continuous Positive Airway Pressure (CPAP), High Flow Nasal Cannula (HFNC) or non-invasive ventilation (NIV), have been successfully applied to manage moderate to severe Hypoxemic Acute Respiratory Failure (HARF) [1,2,3,4,5]. A potential drawback associated to the use of NRS in patients with HARF, is the occurrence of strenuous spontaneous inspiratory efforts leading to large negative swings in intra-thoracic pressure and large swings of dynamic transpulmonary pressure (ΔPLDyn) that may cause Patient Self Induced Lung Injury (P-SILI) [6].

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