Published: 17 January 2022
Author(s): Giulia Bandini, Laura Cometi, Esterita Accogli, Andrea Domanico, Lorenzo Tofani, Cosimo Bruni, Silvia Bellando-Randone, Gemma Lepri, Martina Orlandi, Serena Guiducci, Khadija El-Aoufy, Gabriele Ciuti, Alessia Fabbri, Marco Matucci-Cerinic, Alberto Moggi-Pignone, Study Group of Rheumathology and Internal Medicine
Issue: June 2022
Section: Original article

Systemic sclerosis (SSc) is a complex disease with a heterogenous clinical spectrum and a complex pathophysiology characterized by immune activation and diffuse microvascular injury resulting in internal organ fibrosis [1,2].

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