Patients with heart failure (HF) are particularly vulnerable to systemic infection; however, the combined impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, viral burden, and emerging viral variants on outcomes in established HF remains incompletely defined. We investigated the independent association between SARS-CoV-2 infection and adverse in-hospital outcomes and evaluated the prognostic relevance of viral load and variant-specific patterns.
