March 2016

19 Articles

No Section


1 April 2016

Letter to the Editor

Safety and clinical effectiveness of propofol for endoscopic retrograde cholangiopancreatography

22 March 2016
Author(s): Aleksandar Knežević, Mirjana Stojšić, Ljiljana Gvozdenović

Endoscopic retrograde cholangiopancreatography (ERCP) is an uncomfortable procedure that requires adequate sedation or general anesthesia for successful completion. For instance, over 48,000... more

Efficacy and effectiveness of sublingual immunotherapy for grass pollen allergy

21 March 2016
Author(s): Francesco Marcucci

I was very surprised by the letter “Efficacy but not effectiveness of sublingual immunotherapy for grass pollen allergy: time to avoid waste in health care expenditure” by Corrao et al. published in... more

Imatinib mesylate for unmutated hypereosinophilic syndromes: Does it work?

8 March 2016
Author(s): Grzegorz Helbig

The high efficacy of tyrosine kinase inhibitor, imatinib mesylate (IM), is well-documented in patients with hypereosinophilic syndromes (HES) and detectable rearrangements of platelet-derived growth... more

Letters to the Editor

Validation of immune thrombocytopenia diagnosis code in the French hospital electronic database

21 March 2016
Author(s): Guillaume Moulis, Johanne Germain, Daniel Adoue, Odile Beyne-Rauzy, Hélène Derumeaux, Laurent Sailler, Maryse Lapeyre-Mestre

Immune thrombocytopenia (ITP) is a rare autoimmune disorder leading to platelet destruction and inadequate platelet production, resulting in a risk of spontaneous bleeding. The incidence of ITP... more

No correlation between health care expenditure and mortality in the European Union

14 March 2016
Author(s): Giuseppe Lippi, Camilla Mattiuzzi, Gianfranco Cervellin

There is ongoing debate about the impact of aggregate health care expenditure on health outcomes, and it also remains quite uncertain whether increasing health spending may be a significant factor... more

Original Article

Yield of workup for patients with idiopathic presentation of the syndrome of inappropriate antidiuretic hormone secretion

23 March 2016
Author(s): Daniel Shepshelovich, Chiya Leibovitch, Alina Klein, Shirit Zoldan, Tzippy Shochat, Hefziba Green, Benaya Rozen-zvi, Meir Lahav, Anat Gafter-Gvili

To determine the proportion of patients for whom the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the presenting symptom of an underlying disorder, to describe the yield of... more

Acute and chronic anemia and short- and long-term outcome of patients with peripheral arterial disease and critical limb ischemia

22 March 2016
Author(s): Florian Lüders, Christiane Engelbertz, Matthias Meyborg, Eva Freisinger, Nasser M. Malyar, Thomas Zeller, Holger Reinecke

Evident data about the additive effect of “the fifth cardiovascular risk factor” (anemia) and peripheral arterial disease (PAD) focused on morbidity and outcome of patients with PAD are currently... more

Analysis of environmental risk factors for pulmonary embolism: A case-crossover study (2001–2013)

21 March 2016
Author(s): Javier de Miguel-Díez, Rodrigo Jiménez-García, Ana López de Andrés, Valentín Hernández-Barrera, Pilar Carrasco-Garrido, Manuel Monreal, David Jiménez, Luis Jara-Palomares, Alejandro Álvaro-Meca

The relationship between environmental factors and pulmonary embolism (PE) has received little attention. The aim of this study was to estimate the influence of climatological factors and air... more

Prior thromboprophylaxis and outcome in patients experiencing acute venous thromboembolism after an acute medical illness

11 March 2016
Author(s): Adel Merah, Laurent Bertoletti, Mouzayan Ginzarly, David Zeltser, Manuel Barrón, Inmaculada Cañas, Jaume Villalta, Eugenio Bucherini, Manuel Monreal, on behalf of the RIETE investigators

Even despite the use of thromboprophylaxis, some patients with an acute medical illness develop symptomatic venous thromboembolism (VTE). It is unclear whether the outcome in these patients is... more

Recurrence of venous thromboembolism in patients with recent gestational deep vein thrombosis or pulmonary embolism: Findings from the RIETE Registry

10 March 2016
Author(s): Giovanni Barillari, Ambrogio P. Londero, Benjamin Brenner, Dolores Nauffal, Juan Francisco Sánchez Muñoz-Torrero, Fátima del Molino, Farès Moustafa, Olga Madridano, Francisco Martín-Martos, Manuel Monreal, RIETE Investigators

The aim of this study was to investigate the recurrence rate of venous thromboembolism (VTE) and the prevalence of major bleeding or death in patients with previous VTE in pregnancy and puerperium.... more

Do heterozygous and homozygous Factor V Leiden carriers differ regarding risk for incident and recurrent venous thromboembolism? A retrospective cohort study

9 March 2016
Author(s): J. Perez Botero, W.D. Ormsby, A.A. Ashrani, R.D. McBane, W.E. Wysokinski, M.M. Patnaik, B.R. Lewis, D.E. Grill, R.K. Pruthi, J.A. Heit

While Factor V Leiden (F5 rs6025 A allele) is a known venous thromboembolism (VTE) risk factor, VTE risk among heterozygous vs. homozygous carriers is uncertain.

The sudden death of Alaric I (c. 370–410AD), the vanquisher of Rome: A tale of malaria and lacking immunity

9 March 2016
Author(s): Francesco M. Galassi, Raffaella Bianucci, Giacomo Gorini, Giacomo M. Paganotti, Michael E. Habicht, Frank J. Rühli

Alaric I (c. 370–410AD), King of the Visigoths, sacked Rome for the second time in over eight centuries of history. Historians suggest that malaria, probably contracted either in Rome or in the... more

Coexisting chronic conditions in the older population: Variation by health indicators

1 March 2016
Author(s): Alessandra Marengoni, Sara Angleman, Bettina Meinow, Giola Santoni, Francesca Mangialasche, Debora Rizzuto, Johan Fastbom, Renè Melis, Marti Parker, Kristina Johnell, Laura Fratiglioni

This study analyzes the prevalence and patterns of coexisting chronic conditions in older adults.

Association of initial rhythm with neurologically favorable survival in non-shockable out-of-hospital cardiac arrest without a bystander witness or bystander cardiopulmonary resuscitation

1 March 2016
Author(s): Tatsuma Fukuda, Naoko Ohashi-Fukuda, Takehiro Matsubara, Kent Doi, Yoichi Kitsuta, Susumu Nakajima, Naoki Yahagi

Out-of-hospital cardiac arrest (OHCA) has a predominantly non-shockable rhythm. Non-shockable rhythm, and the absence of a bystander witness or bystander cardiopulmonary resuscitation (CPR) are... more

Cost-minimization analysis favors outpatient quick diagnosis unit over hospitalization for the diagnosis of potentially serious diseases

1 March 2016
Author(s): Carmen Sanclemente-Ansó, Xavier Bosch, Albert Salazar, Ramón Moreno, Cristina Capdevila, Beatriz Rosón, Xavier Corbella

Quick diagnosis units (QDUs) are a promising alternative to conventional hospitalization for the diagnosis of suspected serious diseases, most commonly cancer and severe anemia. Although QDUs are as... more

Reflections in Internal Medicine

The geriatric management of frailty as paradigm of “The end of the disease era”

19 March 2016
Author(s): Matteo Cesari, Emanuele Marzetti, Ulrich Thiem, Mario Ulises Pérez-Zepeda, Gabor Abellan Van Kan, Francesco Landi, Mirko Petrovic, Antonio Cherubini, Roberto Bernabei

The sustainability of healthcare systems worldwide is threatened by the absolute and relative increase in the number of older persons. The traditional models of care (largely based on a disease-... more

Review Article

Frailty measurement in research and clinical practice: A review

30 March 2016
Author(s): Elsa Dent, Paul Kowal, Emiel O. Hoogendijk

One of the leading causes of morbidity and premature mortality in older people is frailty. Frailty occurs when multiple physiological systems decline, to the extent that an individual's cellular... more

Cardiorenal syndrome type 4: From chronic kidney disease to cardiovascular impairment

6 March 2016
Author(s): Antonio Granata, Anna Clementi, Grazia Maria Virzì, Alessandra Brocca, Massimo de Cal, Viviana Rosalia Scarfia, Luca Zanoli, Claudio Ronco, Salvatore Corrao, Lorenzo Malatino

Cardiorenal syndrome type 4 (CRS type 4), or chronic renocardiac syndrome, has been defined as “chronic abnormalities in renal function leading to cardiac disease” and recognizes the extreme burden... more


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