Celiac disease (CD) is a gluten-induced, inflammatory disease of the small intestine, characterized by high and rising prevalence, huge clinical variability, and increased co-morbidity and mortality [1,2]. Despite these prominent features, the majority of celiac patients remains, both in childhood and adulthood, undiagnosed and cannot benefit from gluten-free diet treatment [3,4]. Socioeconomically deprived children are the most likely to be underdiagnosed [5].