Sepsis is a potentially fatal systemic disease characterized by dysregulated immune response to infection [1]. Despite significant improvements in early detection and management, sepsis continues to be a major cause of morbidity and mortality worldwide [2]. Each year, sepsis affects 47–50 million people globally and accounts for approximately 11 million fatalities [3]. In Europe alone, around 3.4 million individuals are affected annually, with nearly 700,000 deaths [4]. Significant effort has been made to identify risk factors that can influence the clinical course and outcome of sepsis.
