October 2025
41 ArticlesNo Section
Diagnostic contribution of minor salivary glands biopsy in clinical practice
Dear Editor,
Clinical Insights
Stroke prevention in atrial fibrillation patients with end-stage renal disease: how far from Ithaca after a long Odyssey?
Atrial fibrillation (AF) and chronic kidney disease (CKD) are closely interlinked clinical entities that frequently coexist [1–3] . CKD predisposes to AF through structural, inflammatory and... more
Commentary
Addressing polymorbidity in chronic obstructive pulmonary disease: an opportunity to improve outcomes
Comorbid diseases are a common feature of chronic obstructive pulmonary disease (COPD), with most deaths among COPD patients from diseases other than chronic respiratory disease [1,2]. The importance... more
When the discovery of a biomarker stimulates basic interdisciplinary work on disease’s biology and pathophysiology
The paper by Aimo et al. [1] reported in the current issue of the European Journal of Internal Medicine highlights a significant increase in the gamma-glutamyltransferase enzyme (GGT) in patients... more
Hijacked medical journals rank first via search engine optimization and threaten academic integrity
The rise of questionable journals poses a significant threat to academic integrity, resulting in substantial waste of institutional and university resources. This commentary analysis focuses on six... more
Artificial intelligence in ECG interpretation: Promise and pitfalls of AI in modern medicine
The integration of artificial intelligence (AI) into cardiovascular diagnostics, particularly through electrocardiogram (ECG) analysis, represents one of the most promising frontiers in contemporary... more
Senolytic drugs to slow down aging: The Fountain of Youth, revisited
Aging leads to progressive organ dysfunction, and many chronic degenerative diseases are characterized by accelerated aging of organs and apparatus. Thus, disentangling the effects of aging and age-... more
Uric acid and heart failure with mildly reduced ejection fraction (HFmrEF): one more step
Uric acid (UA) is the terminal product of purine catabolism and arises from both endogenous nucleic acid turnover and exogenous intake—particularly from diets rich in animal protein and fructose [1... more
Corrigendum
Corrigendum to “Telemedicine in Internal Medicine: a statement by the European Federation of Internal Medicine” [European Journal of Internal Medicine 112C (2023) 138-139]
The authors regret that the author names were listed incorrectly in the manuscript, resulting in the author forenames and surnames becoming reversed. The correct presentation of the authorship is as... more
Internal Medicine Flashcard
Smoking-induced “Scleroderma-like Pattern” and digital clubbing in a young adult
A 24-year-old man with a 10-year history of heavy cigarette smoking (approximately 20 cigarettes per day) was evaluated for recurrent episodes of cold-induced hand erythema and bilateral digital... more
Fever and eye swelling in a teenager
A 16-year-old male with a history of atopic dermatitis presented to his primary care clinic after 7 d of nasal discharge and obstruction, followed by fever and periorbital swelling, which resulted in... more
Atypical and fatal presentation of acute liver failure
A 44-year-old female presented to the emergency department with fever (38 °C) and general malaise three days after an elective hysterectomy for bleeding uterine fibroids. The procedure was... more
Invited Review Article
Senolytic therapies for cardiovascular aging: tackling fibrosis and metabolic dysfunction
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, with its prevalence rising sharply with age [1,2]. Cellular senescence has emerged as a pivotal... more
Letter to the Editor
Aortic valve calcification as a novel risk marker for kidney function deterioration: insights from the MESA study
Dear Editor,
Unaddressed limitations in triglyceride management among CHD patients: A call for methodological rigor
We have carefully reviewed the article by Ilay Shani and Avishay Elis, “The Approach to Triglyceride Levels in Patients with Coronary Heart Disease,” and commend the authors for their comprehensive... more
Unmeasured burdens in nonagenarian ICU survivors: A cohort-based perspective
I read with interest the recent study by Weller and colleagues on excess mortality in ICU patients aged 90 years and older. Their use of relative survival provides instructive information about... more
Classification of coronary syndromes: Need for refinement?
In addition to providing a common language, and thus facilitating communication among professionals, medical classifications aim to incorporate clinical and pathophysiological elements that help... more
Efficacy and safety of beta-blockers in patients with comorbid chronic obstructive pulmonary disease and cardiovascular disease
To the editor: Chronic Obstructive Pulmonary Disease (COPD) and cardiovascular disease (CVD) often co-occur, presenting complex management challenges due to concerns over the effects of beta-blockers... more
Addressing unmet needs in the use of SGLT2 inhibitors in critical and acute care setting
Despite mounting evidence of benefit in acute heart failure (AHF), acute myocardial infarction (AMI), arrhythmias, and even intensive care settings, there remains a significant lack of clear guidance... more
Role of 12-lead electrocardiogram for identifying very low mortality risk patients with non-hypotensive acute pulmonary embolism
Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality and a significant global health issue [1]. The simplified Pulmonary Embolism Severity Index (sPESI) is a practical tool... more
Real-world glucose-lowering strategies for managing glucocorticoid-induced diabetes in non-intensive hospital settings
A prolonged administration of glucocorticoids (GCs) can lead to side effects such as glucocorticoid-induced diabetes (GC-DM), a form of secondary diabetes, namely drug- or chemical-induced diabetes [... more
Gastroenteritis caused by Shiga-toxigenic Escherichia coli. Are antibiotics always prohibited in this disease?
Dear Editor-in-Chief and editorial team,
Validation of different acute kidney injury scores in patients undergoing transcatheter aortic valve implantation
Contrast-associated acute kidney injury (CA-AKI) remains one of the most relevant procedural complications in patients undergoing transcatheter aortic valve implantation (TAVI). Beyond contrast dye... more
Unmasking atrial cardiomyopathy in middle-aged patients with AF: A call for early detection
Atrial cardiomyopathy (AtCM) has emerged as a critical clinical entity in recent years, encompassing structural, architectural, electrical, and functional abnormalities in the atria [1]. Atrial... more
Nonarteritic anterior ischemic optic neuropathy and glucagon-like peptide-1 receptor agonists: Evaluating a potential association
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for type 2 diabetes mellitus (T2DM) and obesity due to their efficacy in glycemic control, weight reduction, and... more
The role of the hospitalist in Europe: results by EFIM multimorbidity working group survey
The increasing prevalence of chronic diseases has led to a population with a higher level of care complexity. Multimorbidity (MM) has emerged as the most prevalent patient profile in both outpatient... more
Genotype-phenotype correlations and resistance to colchicine in a familial Mediterranean fever cohort in southwestern Spain
Familial Mediterranean Fever (FMF) is the most frequent autoinflammatory disease, characterized by recurrent episodes of fever, abdominal pain, arthritis, and rash. It primarily affects people in the... more
Abrupt fluoroquinolone-associated suicides: a SONAR report from North America, Europe, Australia, and Asia
One billion doses of fluoroquinolone (FQ) antibiotics have been administered since 1987. In 1998, the German Pharmaceutical Regulatory Agency received “a few” suicide reports that occurred shortly... more
Trends in cardiovascular disease-related mortality among adults with sleep apnea in the United States from 1999-2020
Cardiovascular disease-related mortality in adults with comorbid sleep apnea in the United States from 1999 to 2020.
Original Article
Non cardiovascular comorbidities in Heart Failure. An updated position paper from the Heart Failure Working Group of the Italian Society of Cardiology (SIC)
Heart Failure (HF) affects more than 64 million people worldwide[1]. While the incidence of HF has stabilized, its prevalence is increasing due to the ageing of the population, improvements in the... more
A person-centred clinical approach to the multimorbid patient with COPD
Multimorbidity, the coexistence of multiple non-communicable diseases in an individual, is a growing concern, especially in an aging population [1]. Patients with chronic obstructive pulmonary... more
Prognostic impact of uric acid levels in heart failure with mildly reduced ejection fraction: Insights from a large retrospective registry
Elevated uric acid (UA) levels represent an established risk factor for cardiovascular morbidity and mortality [1–3]. Numerous investigations have demonstrated an association between increased UA and... more
Sex-related differences in the management and outcome of intubated adults with community-acquired pneumonia in Europe: A multicentre study
Sex and gender are increasingly recognized determinants in the epidemiology, clinical presentation, management, response to treatment, and prognosis of chronic and acute diseases [1]. Sex refers to... more
Neurologic and psychiatric disorders following correction of profound hyponatremia - A cohort study
Hyponatremia, defined as a serum sodium concentration <135 mmol/L, is the most common electrolyte imbalance, seen in 15–20 % of all acute hospital admissions [1]. Women, elderly, and individuals... more
Prognostic value of N-terminal prohormone B-type natriuretic peptide modified by renal function in patients with acute heart failure
Heart failure (HF), as the final phase of various cardiovascular disorders, imposes a formidable global healthcare challenge due to its diverse morbidity and high rate of mortality [1]. HF and kidney... more
Determinants of time to first palliative care consultation in hospitalized patients with advanced or terminal illness – A retrospective analysis
The Yentl Syndrome, a term coined by Dr. Bernadine Healy in 1991, refers to the phenomenon that women are less likely to receive accurate diagnosis and treatment because their symptoms do not align... more
Gamma-glutamyltransferase independently predicts mortality and heart failure hospitalization in cardiac transthyretin amyloidosis
Transthyretin cardiac amyloidosis (ATTR-CA) is an infiltrative cardiomyopathy caused by extracellular deposition of misfolded transthyretin (TTR) fibrils within the myocardium, leading to progressive... more
Long-term secondary prevention with colchicine in patients with CAD: an updated systematic review and meta-analysis
Randomized clinical trials (RCTs) for the prevention of vascular events in patients with coronary artery disease (CAD) over the past decade have clearly demonstrated that colchicine is able to reduce... more
Review Article
Optimizing PCSK9 inhibitor therapy: Understanding and managing suboptimal LDL-C response in clinical practice
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality globally[1]. Elevated levels of low-density lipoprotein cholesterol (LDL-C) are a well-recognized... more
When inflammatory bowel disease meets pregnancy
Inflammatory bowel disease (IBD) is a group of chronic and relapsing inflammatory conditions of the gastrointestinal tract with two major forms: Crohn’s disease (CD) (affecting any segment of the... more
Artificial intelligence and the electrocardiogram: A modern renaissance
The electrocardiogram (ECG) is a fundamental, non-invasive diagnostic tool in cardiology, widely accessible and crucial for assessing the heart's electrical and structural conditions [1].... more