Published: 29 January 2015
Author(s): Paolo Magni, Chiara Macchi, Beatrice Morlotti, Cesare R. Sirtori, Massimiliano Ruscica
Section: Review Article

The use of statins for cardiovascular disease prevention is clearly supported by clinical evidence. However, in January 2014 the U.S. Food and Drug Administration released an advice on statin risk reporting that “statin benefit is indisputable, but they need to be taken with care and knowledge of their side effects”. Among them the by far most common complication is myopathy, ranging from common but clinically benign myalgia to rare but life-threatening rhabdomyolysis. This class side effect appears to be dose dependent, with more lipophilic statin (i.e.

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