Published: 29 April 2020
Author(s): Loukianos S Rallidis, Andreas Katsimardos, Nikolaos Kosmas, Taxiarchoula Rallidi, Antonia Kountouri
Section: Letter to the Editor

Adiponectin is a circulating cytokine produced by the adipose tissue. Experimental data suggest that adiponectin exerts beneficial effects on insulin sensitivity, chronic low-grade inflammation, oxidative stress and atherosclerotic process [1]. Paradoxically, the majority of studies that addressed the association of circulating adiponectin levels with cardiovascular (CV) or total mortality, have found a positive, rather than the expected negative, relationship between adiponectin and mortality [2].

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