Published: 4 August 2020
Author(s): Marcel Levi
Section: Commentary

Disseminated intravascular coagulation (DIC) is a complication of a myriad of disorders that are all associated with a systemic inflammatory response. DIC is considered as an important pathogenetic pathway contributing to organ dysfunction, for example in sepsis, severe trauma or other conditions [1]. Any form of systemic inflammation will often be associated with activation of coagulation, ranging from changes in molecular markers in coagulation factors with equivocal clinical significance to its most full-blown variant, which is DIC [2].

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