Sepsis is a life threatening syndrome in which a dysregulated host response to infection leads to life-threatening organ dysfunction [1]. In-hospital mortality for patients with sepsis is about 10% [1]. Hyperthermia is a common symptom of sepsis, but septic patients with hypothermia have higher mortality rates than patients with hyperthermia [2]. Thus, fever appears to have a protective role in patients with sepsis. In the Netherlands, some patients with sepsis receive paracetamol in the ambulances, mostly for pain management as fever is not an indication for administration of paracetamol in the Dutch Ambulance Protocol [3].
