The pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) generated much interest on the basic pathogenetic mechanisms through which SARS-CoV-2 damages diverse organ systems including the lungs, heart, brain, kidney, and vasculature. [1] In June 2020, the European Journal of Internal Medicine hosted a paper from our group which presented a unified pathophysiological hypothesis on some basic aspects of the disease [2].