Published: 8 August 2025
Author(s): Davide Antonio Mei, Francesco Tritto, Jacopo Francesco Imberti, Marco Vitolo, Giuseppe Boriani
Section: Clinical Insights

Atrial fibrillation (AF) and chronic kidney disease (CKD) are closely interlinked clinical entities that frequently coexist [1–3] . CKD predisposes to AF through structural, inflammatory and neurohormonal mechanisms including hypertension, atrial enlargement, and systemic inflammation[4]. Conversely, AF may contribute to CKD progression by reducing renal perfusion and promoting neurohormonal activation[4]. Patients with both conditions carry a disproportionately high risk of stroke, bleeding, cardiovascular events, and all-cause mortality [1].

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