Published: 21 September 2026
Author(s): Maria Cristina Vedovati, Ludovica Anna Cimini, Iolanda Enea, Manuela Romei, Giulio Righini, Giuseppe Pio Martino, Paola Mogni, Edoardo Pennacchio, Natale Vazzana, Annamaria Dachille, Giuseppe Francesco Fuscaldo, Francesco Di Filippo, Chiara Angotti, Donata Lucci, Cecilia Becattini, on behalf of COPE Investigators
Issue: October 2026
Section: Original Article

In clinical practice, and in accordance with international guidelines, computed tomography pulmonary angiography (CTPA) is currently the gold-standard imaging test for diagnosing acute pulmonary embolism (PE) in patients with suspected PE [1–3]. When properly performed, CTPA enables direct visualization of the pulmonary arteries and any emboli, allowing for an accurate assessment of their location within the pulmonary arterial tree [4–10]. Proximal localization of emboli (in the main or lobar pulmonary arteries) has recently been integrated as a key criterion to identify patients with acute PE who may be candidates for percutaneous reperfusion therapies.

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