Aging entails a progressive impairment of functions and, ultimately, leads to increased susceptibility to disability, morbidity, and mortality. Around 85% of people aged more than 75 years suffer from chronic diseases. Patients with chronic conditions often present a complex interplay of multimorbidity, polypharmacy and frailty, which are influenced by several characteristics of individuals, including biological sex (i.e., biological attributes, determined by the sex chromosomes, genes, reproductive and endocrine system) and sociocultural gender (i.e., a social construct which refers to culture-bound conventions, roles, and behaviours of individuals).
