We read with great interest the article by Sabrina Scilletta et al. published in the European Journal of Internal Medicine, which explored the relationship between cognitive function and subclinical vascular injury in patients with familial hypercholesterolemia (FH) [1]. The authors reported that 20 % of FH patients exhibited cognitive dysfunction—a rate higher than that observed in the general population of the same age. Furthermore, they found that patients with cognitive impairment had higher LDL-C levels, higher DLCN scores, and elevated pulse wave velocity (PWV) and carotid intima-media thickness (IMT).
