Transthyretin amyloid cardiomyopathy (ATTR-CM) and aortic stenosis (AS) frequently coexist in elderly patients, particularly men, creating a complex clinical scenario with overlapping symptoms and imaging features. Both conditions are strongly age-dependent, and their association is increasingly recognized as more than coincidental. Transthyretin deposits have been identified within stenotic aortic valves, supporting the hypothesis that mechanical stress and shear forces may promote protein misfolding and amyloid deposition.
