March 2026
41 ArticlesNo Section
Corrigendum to “The changing landscape of Heart Failure: translating management into the modern era” [European Journal of Internal Medicine (2026) 106633]
The authors regret that in Figure 1 the name of the drug Sacubitril/Valsartan was incorrectly reported as sacubutril valsartan. This was a typographical error, and the figure has now been corrected... more
Is left ventricular hypertrophy a reliable predictor of renal and cardiac outcome in IgA nephropathy?
Cardiovascular disease (CVD) is the most important cause of adverse clinical outcome in chronic kidney disease (CKD), due to shared etiopathogenetic factors and common pathophysiological mechanisms [... more
The changing landscape of heart failure: translating management into the modern era
Heart failure (HF) is a complex clinical syndrome associated with high morbidity and mortality, accounting for approximately 2 % of total healthcare expenditures. Despite advances in pharmacological... more
From networks of data to networks of care in clinical medicine: this is not artificial intelligence
The increasing availability of clinical, omic, and imaging data in clinical medicine opens unprecedented opportunities to uncover hidden patterns and mechanistic insights into disease. Available... more
Survival effect of early high-flow nasal oxygen after extubation: Statistical, methodological, and ethical concerns
We read with great interest the article by Ishihara et al. evaluating the survival impact of early high-flow nasal oxygen (HFNO) following extubation in intensive care patients [1] Although the... more
Clinical Insights
Integrating the lungs and the nervous system: Redefining chronic obstructive pulmonary disease care
We read with great interest the article by Mannino et al., which offers a thoughtful and balanced discussion on the clinical relevance of comorbidities in chronic obstructive pulmonary disease (COPD... more
Commentary
SGLT-2 inhibitors in heart failure with preserved and mildly reduced ejection fraction: a big step forward but still a long way to go
Heart failure with preserved ejection fraction (HFpEF) is a complex and multifactorial heart disease that traditionally has had no effective therapy options beyond congestive symptom’s control [1].... more
Hypertriglyceridemia-mediated acute pancreatitis: timely attention for an underdiagnosed and severe disease
In this issue of the European Journal of Internal Medicine a narrative review on hypertriglyceridemia-mediated acute pancreatitis (HTG-AP) is published by Subramanian et al. [1]. This well written... more
Editorial
A hierarchized proposal to integrate steatotic liver disease in cardiometabolic care: A new mindset to evaluate MASLD in Internal medicine
The introduction of direct-acting antivirals against hepatitis C virus (HCV) signaled the end of a major era in liver disease, while simultaneously opening new opportunities for medical research and... more
Internal Medicine Flashcard
Recurrent postprandial mandibular swelling with systemic symptoms: a diagnostic challenge
A 56-year-old woman with allergic rhinitis presented to the emergency department with severe lower abdominal pain and generalized wheals shortly after lunch. Blood tests and abdominal CT were... more
Demyelinating or compressive myelopathy
A 29-year-old male presented with an eight-month history of progressive ambulation difficulty and a four-month history of urinary hesitancy. He reported no family history of neurological or... more
Letter to the Editor
Monitoring for atrial fibrillation recurrence following transient new-onset atrial fibrillation
We thank Yang and colleagues for their interest in our study on the time-to-detection of recurrent atrial fibrillation (AF) in patients with transient new-onset AF detected during hospitalization for... more
Advancing beyond multimodality: integrating quantitative imaging biomarkers into the clinical workflow of cardiac amyloidosis. Author’s reply
We thank Jiang and colleagues for their interesting Letter [1] and for the generous attention dedicated to our review on multimodality imaging in cardiac amyloidosis (CA) [2]. We greatly appreciate... more
Challenges in defining difficult-to-treat rheumatoid arthritis in the elderly: Channeling bias, sarcopenia, and the age paradox. Author’s reply
Dear Editor,
Reassessing the safety signal: Dihydropyridine calcium channel blockers in the era of quadruple therapy for heart failure. Author's reply
We read with interest the letter by Wang et al [1] regarding our recently published paper on prescription patterns and outcomes associated with dihydropyridine calcium channel blockers (DHP-CCBs)... more
“One size does not fit all”: Personalized approach to define appropriate level of palliative care in newly diagnosed idiopathic pulmonary fibrosis patients
Idiopathic pulmonary fibrosis (IPF) is still a disease in which patients' clinical needs and the delivery of palliative care (PC) are mismatched. International societies recommend integrating PC for... more
Challenges in inpatient diabetes care: A single-day snapshot or a shot at the heart of the problem?
We read with great interest the thoughtful comments from Wang et al. [1] regarding our article, “Gaps in Glycaemic Monitoring and Underuse of Cardioprotective Glucose-Lowering Agents: Challenges of... more
On the urgency of redefining endpoints and precision stratification in extended monitoring for atrial fibrillation
McIntyre et al. have made a significant contribution to the growing body of evidence supporting extended ambulatory electrocardiogram monitoring in patients with transient new-onset atrial... more
Reassessing the safety signal: Dihydropyridine calcium channel blockers in the era of quadruple therapy for heart failure
Dear Editor,
Challenges in defining difficult-to-treat rheumatoid arthritis in the elderly: Channeling bias, sarcopenia, and the age paradox
We read with great interest the recent original article by Jung et al., entitled “Difficult-to-treat rheumatoid arthritis among elderly patients from the KOBIO registry,” published in the European... more
Advancing beyond multimodality: integrating quantitative imaging biomarkers into the clinical workflow of cardiac amyloidosis
We read with great interest the comprehensive narrative review by Sinigiani et al. titled "Multimodality imaging for cardiac amyloidosis: clinical applications and future directions" published in the... more
Addressing gaps in inpatient diabetes management: A call for integrated multidisciplinary approaches
We commend Porth et al. for their timely and insightful study, "Gaps in Glycaemic Monitoring and Underuse of Cardioprotective Glucose-lowering Agents," which elucidates critical deficiencies in... more
Tirzepatide as adjunct to insulin for the treatment of type 1 diabetes
Based on the latest published data, global prevalence of type 1 diabetes (T1D) was 8.4 million individuals in 2021, with 18 % of them being younger than 20 years, 64 % aged 20–59 years and 19 % aged... more
Optimization and clinical applicability of monitoring strategies: further exploration of the monitoring of transient new-onset atrial fibrillation recurrence
We read with great interest the study by McIntyre et al. on the monitoring time and recurrence detection rate of transient new-onset atrial fibrillation (AF) [1]. The study provides valuable... more
Direct oral anticoagulant dose optimization in cancer-associated thrombosis: Current evidence and implications for extended therapy
Cancer-associated thrombosis (CAT) remains a leading cause of morbidity and mortality. Important risk factors in this population include chemotherapy, hormonal therapies, indwelling catheters or... more
Inpatient diabetes management in Europe: The limits of a single-day snapshot
We read with great interest the article by Porth et al. [1], titled "Gaps in Glycaemic Monitoring and Underuse of Cardioprotective Glucose-lowering Agents: Challenges of inpatient diabetes care... more
Physical activity in systemic vasculitis
Dear Editor,
Beyond the algorithm: The human interface of medicine
“You should stand at the right side of the patient’s bed.” [1]
Mepolizumab improves health-related quality of life in patients with hypereosinophilic syndrome
Hypereosinophilic syndrome (HES) is a rare, heterogeneous disorder, characterised by high eosinophil levels (≥1500 cells/µL) and eosinophilic inflammation leading to multiorgan dysfunction and damage... more
Beyond binary Sex: Hormonal and physiological determinants of VTE outcomes
Dear Editor,
Left ventricular remodeling in IgA nephropathy — clinical applicability and lessons from real-world practice
I read with great interest the study by Jin[1], which examines the prognostic implications of distinct left ventricular (LV) geometric patterns in patients with biopsy-proven IgA nephropathy (IgAN).... more
Original Article
Recent trends and future projections of atrial fibrillation epidemiology in a large european population
Atrial fibrillation (AF) is a major public health concern with a rising global epidemiological burden and marked regional variability. We analysed AF epidemiology, trends, and future projections in a... more
Risk of endocarditis in patients with bacteraemia by coagulase-negative staphylococci; a multicenter retrospective cohort
Infective endocarditis (IE) is a serious and under-recognized complication of coagulase-negative staphylococci (CoNS) bacteraemia. The aim was to identify predictors of IE in patients with CoNS... more
Association between interleukin-6, C-reactive protein and chronic kidney disease outcomes: A systematic review and meta-analysis
Chronic kidney disease (CKD) is a progressive disorder defined by structural or functional kidney abnormalities persisting for at least three months. According to KDIGO criteria, CKD is diagnosed by... more
Ultrasound-based evaluation of inspiratory muscle effort in patients with type 2 respiratory failure secondary to exacerbation of chronic obstructive pulmonary disease
Exacerbations of chronic obstructive pulmonary disease (ECOPD) are a major cause of acute hypercapnic respiratory failure. Diaphragmatic dysfunction is common, often accompanied by compensatory... more
Fractional exhaled nitric oxide in acute exacerbations of chronic obstructive pulmonary disease: A meta-analysis with meta-regressions
Fractional exhaled nitric oxide (FeNO) has emerged as a useful tool for monitoring airway inflammation in chronic obstructive pulmonary disease (COPD) patients. We designed a systematic review and... more
Robustness of randomized controlled trial evidence for SGLT2 inhibitors in heart failure with preserved and mildly reduced ejection fraction
Sodium–glucose co-transporter 2 inhibitors (SGLT2i) have emerged as a fundamental therapy for patients with heart failure with preserved ejection fraction (HFpEF), a population that has historically... more
Left ventricular remodeling in IgA nephropathy: Prognostic implications and clinical correlations
The determinants and prognosis of left ventricular (LV) geometric remodeling remain uncharacterized in immunoglobulin A nephropathy (IgAN). We investigated the (1) clinicopathological correlates of... more
Cardiovascular-kidney-metabolic domains and impact on antithrombotic treatment, integrated care and clinical outcomes in patients with atrial fibrillation: results from a prospective European registry
Cardiovascular, kidney, and metabolic (CKM) conditions frequently coexist with atrial fibrillation (AF), but their impact in AF population remains poorly characterized.
Review Article
Prevention and treatment of hypertriglyceridemia-mediated acute pancreatitis: A narrative review
Acute pancreatitis can result in death or serious consequences including chronic pancreatitis, diabetes mellitus, and organ failure. Causes of acute pancreatitis include gallstones, alcohol, and... more
Cardiovascular Risk Assessment: Practical Tips for the Internal Medicine Specialist
Cardiovascular diseases remain the leading cause of mortality worldwide, and they also represent a significant burden in terms of health care expenditure, equipment use, therapeutic interventions and... more