Published: 24 November 2025
Author(s): Pierfrancesco Novielli, Roberto Bellotti, Mohamad Khalil, Piero Portincasa, Sabina Tangaro

The increasing availability of clinical, omic, and imaging data in clinical medicine opens unprecedented opportunities to uncover hidden patterns and mechanistic insights into disease. Available tools augment clinical reasoning, equipping clinicians with new layers of understanding to support personalized treatment and transparent risk assessment. More tools are being implemented and will soon enter such a challenging field of study and application.Graph- and sequence-based Artificial Intelligence (AI) operating on these networks underpins the vision of precision medicine, enabling early diagnosis, disease staging, treatment selection, and transparent risk stratification.

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