Published: 4 December 2025
Author(s): Theodora A. Manolis, Antonis A. Manolis, Apostolos Vouliotis, Antonis S. Manolis
Section: Review Article

Epilepsy is one of the major noncommunicable neurological disorders (the other comprising migraine, Alzheimer disease/other dementias, Parkinson’s disease, motor neuron diseases, multiple sclerosis, stroke and head injury) and the most prevalent among patients with cardiovascular (CV) disease (CVD)[1]. These neurological disorders incur a 2-fold higher risk for developing CVD with epilpesy linked with the greatest odds ratio (2.25) [1]. It is considered that CVDs can influence the function of the brain, and many brain diseases are linked with CV dysfunction, in a resiprocal relationship termed the heart-brain axis [2].

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