The differentiation between sarcoidosis and sarcoid-like reactions still remains a debated issue. Current diagnostic criteria for cutaneous sarcoidosis are not adequately implemented in the clinical practice and have not been fully evaluated in several studies [1]. Various authors have hypothesized that some tissue antigens in sarcoid granulomas are pathogenetic factors also for sarcoidosis, hence the assertion that sarcoidosis is a multifactorial disease in certain groups of patients with underlying genetic predisposition [1].
