January 2023
35 ArticlesBook review
WITHDRAWN: Reprint of: Differential diagnosis by laboratory medicine: a quick reference for physicians
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
Case Report
WITHDRAWN: Reprint of: Bone metastasis of a follicular thyroid carcinoma originated in a toxic multinodular goiter
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
Clinical Insights
Natural history of ‘silent’ atrial fibrillation from subclinical to asymptomatic: State of the art and need for research
In the last 30 years clinical research in the atrial fibrillation (AF) field has seen a great advance both in terms of productivity and heterogeneity of areas that developed significant new knowledge... more
Editorial
WITHDRAWN: Reprint of: Diagnosis of Cushing's syndrome
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
Internal Medicine Flashcard
Blurred vision: Hitting the bull's eye
An 18-year-old female presented with progressive blurred vision in both eyes. On evaluation, her uncorrected visual acuity was 20/400 in both eyes. Slit lamp examination revealed bilateral supero-... more
Acute necrosis of the corpus callosum
A 58-year-old man with a history of alcohol use disorder was admitted for apathy, confusion and aphasia of abrupt onset. In addition, clinical examination revealed a tetrapyramidal syndrome. Blood... more
Internal Medicine in Europe
WITHDRAWN: Reprint of: The history of the (Young) AEMI(E) and the EFIM
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
Letter to the Editor
How the theory of centralized aerobic-anaerobic energy balance compensation explains sudden cardiac death in young athletes
This letter should be considered as a follow up comment to the recent publication in the European Journal of Internal Medicine on sudden cardiac death (SCD) in young athletes [1]. The issue of SCD in... more
For whom the bell tolls: Attacks on Ukrainian healthcare threatens us all
Dear Editor
Informed consent process in the I-SPY COVID trial is questionable
We read with interest the letter by Files et al. [1] commenting on our recently published article in which we discussed the inappropriateness of randomizing trial participants before obtaining their... more
Monkeypox infection: Should we expect changes in its epidemiological and clinical features?
We read with interest the excellent review on the outbreak of monkeypox (MPX) by Patauner et al. [1]. The epidemiological scenario was exhaustively described but referred to a pre-vaccination era. In... more
Informed consent process in the ISPY COVID trial is ethically acceptable
The ISPY COVID Investigators would like to respond to Dal-Re et al. in their recent editorial in on the ethics of the consent process in the ISPY COVID Trial [1]. Unfortunately, the authors of the... more
Monkeypox infections in vulnerable groups
Dear editor,
Can a smallpox drug treat monkeypox? Compassionate use of tecovirimat for monkeypox infection
The monkeypox outbreak during the coronavirus disease 2019 (COVID-19) pandemic has given rise to the concern of multiple viral pandemics. Though COVID-19 has been around for three years by now, mass... more
Harm of early dexamethasone for COVID-19 and bias in randomized trials
Numerous unproven therapies for coronavirus disease 2019 (COVID-19) were adopted early on based on inadequate evidence [1]. The Randomized Evaluation of COVID-19 Therapy (RECOVERY) is a large simple... more
Multi-country monkeypox outbreak: A quantitative evidence synthesis on clinical characteristics, potential transmission routes, and risk factors
The world is facing an outbreak of monkeypox. Since early May 2022, more than 60,000 cases of monkeypox have been reported from countries where the disease is not endemic. Monkeypox is a zoonotic... more
Variability in blood testing policy in internal medicine and clinical outcomes
Dear Editor,
Long-standing thrombocytosis often precedes thromboembolic complications heralding the diagnosis of essential thrombocythemia
Myeloproliferative neoplasms (MPN) are clonal diseases of hematopoietic stem cells characterized by the hyperplasia of one or more myeloid cell lines that retain their capacity for terminal... more
Characteristics of JAK2 unmutated erythrocytosis: Distinctive traits between polycythemia vera and non-polycythemia vera patients
Polycythemia is a frequent reason for consultation, and is related to various etiologies. Erythropoietin (EPO) plays a major role in the physiological stimulation of red blood cell (RBC) progenitors... more
WITHDRAWN: Reprint of: Detrimental action of thiazolidinediones on bone (rebuttal)
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
Original Article
Time-trends in disease characteristics and comorbidities in patients with chronic hepatitis B in the period 1980–2020
the American Association for the Study of Liver Diseases
Airflow grades, outcome measures and response to pulmonary rehabilitation in individuals after an exacerbation of severe chronic obstructive pulmonary disease
Individuals with Chronic obstructive pulmonary disease (COPD) are staged according to symptoms and exacerbation (ECOPD) history, (Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups... more
Impact of ABC (Atrial Fibrillation Better Care) pathway adherence in high-risk subgroups with atrial fibrillation: A report from the ESC-EHRA EORP-AF long-term general registry
Atrial fibrillation (AF) is a significant public health issue with a global prevalence of 33.5 million patients affected by the condition and approximately 5 million new cases identified each year [1... more
Effects and differences of sleep duration on the risk of new-onset chronic disease conditions in middle-aged and elderly populations
It is expected that by 2050 the population over 65 in China will reach 400 million [1]. A recent epidemiological study in China has demonstrated that 75.8% of residents over 60 years old suffer from... more
Post-operative recurrence of liver cancer according to antiviral therapy for detectable hepatitis B viremia: A nationwide study
Study highlights
Mobile health-technology integrated care in atrial fibrillation patients with heart failure: A report from the mAFA-II randomized clinical trial
Heart Failure (HF) and Atrial Fibrillation (AF) are two of the most common cardiovascular diseases worldwide, both entailing an increased morbidity and mortality [1,2] Sharing common risk factors and... more
Liver fat accumulation more than fibrosis causes early liver dynamic dysfunction in patients with non-alcoholic fatty liver disease
Overweight and obesity trends are increasing worldwide, and represent a major health problem [1]. The increase in body fat is also associated with insulin resistance and diabetes [2]. In... more
The long-term prognostic value provided by Coronary CT angiography
Risk stratification of patients has a major role in the prevention and treatment of cardiovascular disease [1,2]. In coronary artery disease (CAD), plaque features have incremental value over total... more
Treatment with COLchicine in hospitalized patients affected by COVID-19: The COLVID-19 trial
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) related disease (COVID-19) has caused one of the worst pandemics of modern times [1]. As of Sept 1st, 2022, the disease affected over... more
Review Article
Clinical usefulness of testing for severe acute respiratory syndrome coronavirus 2 antibodies
The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggers both B-cell and T-cell responses directed against all viral antigens including the Nucleocapsid (N) and Spike... more
Giant cell arteritis: Update on clinical manifestations, diagnosis, and management
Giant cell arteritis (GCA) – previously known as Horton's disease or temporal arteritis – is the most common vasculitis affecting people older than 50 years [1]. GCA is characterized by granulomatous... more
“How we treat” clinical dilemmas in antiphospholipid syndrome: A case-based approach
Antiphospholipid syndrome (APS) is an autoimmune condition characterized by thrombosis (arterial, venous, and microvascular) and/or pregnancy morbidity occurring in subjects persistently positive for... more
WITHDRAWN: Reprint of: Thiazolidinediones for the treatment of type 2 diabetes
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
WITHDRAWN: Reprint of: Peripheral arterial disease: A growing problem for the internist
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
WITHDRAWN: Reprint of: Proposal for a multidisciplinary approach to the patient with morbid obesity: The St. Franciscus Hospital Morbid Obesity Program
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.