We read with great interest the study by Rubio-Gracia and colleagues examining the clinical and prognostic significance of the urinary albumin-to-creatinine ratio (UACR) in patients with heart failure enrolled in the RICA-2 registry [1]. The authors provide valuable real-world evidence showing that higher UACR was associated with a greater burden of comorbidities and higher concentrations of congestion-related biomarkers, although it was not independently associated with all-cause mortality or heart failure rehospitalisation after multivariable adjustment.
