Published: 4 June 2026
Author(s): FD Desgorces, A Gouelle, SJ Moss, P Noirez
Issue: June 2026
Section: Invited Review Article

Optimal aging is characterized by older adults maintaining good functional reserves, complete independence, and physiological resilience to stress. Conversely, some elderly individuals exhibit increased vulnerability to stressors and a diminished recovery capacity [1]. Between robust aging and proven dependence lies an intermediate state known as frailty. Frailty is defined as a clinical syndrome reflecting an increased vulnerability to physical and/or psychological stress. It is linked to a slow and latent reduction in functional capacity and is associated with a high risk of adverse events, such as falls, hospitalization, and institutionalization.

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