Published: 12 June 2026
Author(s): Chiara Ceolin, Marina De Rui, Sandro Giannini, Paolo Simioni, Giuseppe Sergi
Issue: June 2026
Section: Letter to the Editor

Complexity has become a defining feature of modern internal medicine. Older adults with multimorbidity, polypharmacy, biological and functional vulnerability, and multidimensional frailty now represent a substantial proportion of hospitalized patients [1]. Nevertheless, despite this profound epidemiological and clinical transformation, the management of internal medicine patients still largely relies on disease-centered and organ-specific models, often lacking tools capable of capturing frailty and multidimensional complexity.

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